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MS Relapse Rates: Measuring MS Treatment Efficacy in …

Posted: Published on August 25th, 2018

Measuring the effectiveness of treatments for multiple sclerosis (MS) is complicated; the disease biology is not entirely understood, and symptoms vary from person to person. While doctors and researchers continue to explore new endpoints for clinical trials that evaluate MS therapies, measuring relapse rates remains one of the most common. Neurologist Enrique Alvarez, M.D., Ph.D., at the University of Colorado, Denver, discusses the importance of continuing to evaluate potential new therapies based on their ability to reduce relapse rates, along with newer measures that are bolstering these evaluations. How do researchers measure the efficacy of new treatments for MS? NEUROLOGIST ENRIQUE ALVAREZ, M.D., PH.D., AT THE UNIVERSITY OF COLORADO, DENVER, EXPLAINS WHY RELAPSE RATES HAVE REMAINED A BENCHMARK IN MS TRIALS. Relapse rates are a benchmark for measuring the efficacy of new MS treatments in clinical trials. A relapse occurs when a new neurological symptom emerges or an old symptom gets worse for at least 24 hours. MS can cause a variety of symptoms such as vision loss, pain, fatigue or impaired coordination. Signs of a relapse can be reported by the patient, and may have an immediate impact on the quality of a patients life. Relapse rates also tend … Continue reading

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ECM for Pericardial Closure – Aziyo

Posted: Published on August 25th, 2018

Tyke was developed based on a request by Pediatric Cardiovascular Surgeons to deliver an ECM material that maintained the biomechanical properties found in our existing products, but was thinner, more pliable and better suited for intracardiac and branch pulmonary artery use in neonates and infants.1 Tykeis intended for use in neonates and infants for the repair of pericardial structures, as an epicardial covering for damaged or repaired cardiac structures, as a patch material for intracardiac defects, septal defect and annulus repair, suture-line buttressing, and cardiac repair. Tykemeets the same biomechanical requirements (tensile strength, suture retention strength and burst strength) as our existing ECM for Cardiac Tissue Repair, and bench testing has shown that Tykeexceeds the specified tensile strength, suture retention strength, and burst strength required for its intended surgical use.2 To assess the biological performance of Tyke, patches were implanted in the descending aorta and pulmonary artery of a growing lamb model.3 Explanted patches were evaluated by an independent, board-certified pathologist. Tykewas found to restore the structural integrity (including the formation of a mature, stable, and fully endothelialized neointima) of the implant site within 90 days (Figure 1). By 180 days, the thickness of the remodeled Tykepatch was similar to … Continue reading

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Cardiac Rehabilitation: Overview, History and Definition …

Posted: Published on August 25th, 2018

Indications Cardiac rehabilitation initially was designed for low-risk cardiac patients. Now that the efficacy and safety of exercise have been documented in patients previously stratified to the high-risk category, such as those with congestive heart failure (CHF), the indications have been expanded to include such patients. Exercise training benefits persons with the following cardiac conditions: Recent myocardial infarction Cardiac transplantation [21] Exercise prescription depends on the results of exercise testing, which often includes cardiopulmonary exercise (CPX) testing. Patients with limitations due to chronic obstructive pulmonary disease (COPD), peripheral vascular disease (PVD), stroke, and orthopedic conditions still can be trained in the exercises through special techniques and adaptive equipment (eg, use of arm-crank ergometer). Cardiac rehabilitation services are contraindicated in patients with the following conditions: Uncompensated heart failure Severe ischemia, LV dysfunction, or arrhythmia during exercise testing Poorly controlled hypertension Hypertensive or any hypotensive systolic blood pressure response to exercise Unstable concomitant medical problems (eg, poorly controlled or "brittle" diabetes, diabetes prone to hypoglycemia, ongoing febrile illness, active transplant rejection) [22] In such patients, every effort should be made to correct these abnormalities through optimization of medical therapy, revascularization by angioplasty or bypass surgery, or electrophysiologic testing and subsequent antiarrhythmic drug … Continue reading

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Difference between Cardiac Arrest and Respiratory Arrest …

Posted: Published on August 25th, 2018

Key Difference: Cardiac Arrest is a heart condition where the heart does not contract properly, thereby failing to effectively circulate blood to the other organs. Cardiac arrest is brought on by irregular beating of the heart that causes it to stop supplying blood flow to the other organs, including the brain. Respiratory arrest is the condition when a person stops breathing as their lungs fail to contract effectively. It prevents the body from delivering oxygen to the body, including the brain causing the person to lose consciousness. Cardiac arrest and respiratory breathing are two conditions that are quite similar to each other as they both cause the patient to lose consciousness. This causes many people to confuse the two medical emergencies, but these are two distinct conditions and should be treated as such. Cardiac arrest and respiratory arrest go hand-in-hand, with one either causing or is caused by the other. Cardiac arrest is when the heart does not contract properly resulting in loss of oxygenated blood throughout the body. Respiratory arrest is when a person stops breathing causing lack of oxygen in the brain. Cardiac Arrest is a heart condition where the heart does not contract properly, thereby failing to … Continue reading

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Hormone Replacement Therapy – Menopause Home Page

Posted: Published on August 25th, 2018

Interested in a Discount on Hormone Replacement Therapy? The lower levels of hormones that occur during menopause may lead to: To help alleviate these problems, some women receive hormone replacement therapy. The medicines used in hormone replacement therapy contain estrogen or estrogen with progestin (another hormone). Hormone replacement therapy works by replacing the natural estrogen your body loses during menopause. Like all medicines, hormone replacement therapy has risks and benefits. After reading this article, talk to your doctor, nurse, or pharmacist for more information about this treatment. If you decide to use hormone replacement therapy, use it at the lowest dose possible that provides relief of your menopausal symptoms. Also, only use the therapy as long as needed -- long-term use of hormone replacement therapy can increase the possible risks involved. Hormone replacement therapy has been shown to be beneficial in: More: Hormone Replacement Therapy - Menopause Home Page … Continue reading

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BioTE Medical | Natural Hormone Balance | Pellet Therapy

Posted: Published on August 25th, 2018

How do you know if your hormones aren't balanced? You will likely feel unwell and not be able to figure out why. Balanced hormones can change your life. The practitioners certified by BioTE Medical have seen the life-changing results time and time again. Learn More Studies have shown that balanced hormones are necessary for good health and disease prevention for women and men throughout the entire lifecycle. However, balanced hormones become even more critical for health as we grow older and more susceptible to disease. Learn More BioTE Medical optimizes hormone levels with bio-identical hormone pellets. Hormone optimization is a process by which levels of hormones throughout the body are equalized through continual absorption of BHRT pellets, leading to peak levels of health and wellbeing. Learn More Hormone pellets release bio-identical hormones into the bloodstream continuously. These are tiny pellets just under the skin, typically placed in the upper hip. BHRT pellets are smaller than a grain of rice and are consistently effective for between 3 and 6 months. Learn More Go here to see the original: BioTE Medical | Natural Hormone Balance | Pellet Therapy … Continue reading

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Human Growth Hormone Replacement & HGH Injections

Posted: Published on August 25th, 2018

Many of us know and have learnt about how hormones are the chemical messengers in the body regulating many vital functions. There are different hormones that work on different areas of the body to keep things running smooth and efficient. Besides wanting to look young, people also have cases of gender identity being confusing and wanting to be the opposite of their gender. In these cases also hormone replacement therapy is vital. For others its about ageing and the discomfort that comes with growing older. People want to look young with wrinkle free skin and vitality that is there during their younger years. They turn to hormone replacement for these reasons as well. Another reason to opt for it is during menopause. Many women experience extreme mood swings and lack of interest as their body goes through a phase called menopause. It is when the ovaries stop producing eggs and this affects levels of estrogen and progesterone in the body. By using supplements of these hormones women can overcome the problems that accompany this huge change in their lives. It is also see that, Hormone replacement therapy is used when people are born with intersex issues. Then early on by … Continue reading

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The Pros and Cons of Hormone Therapy – Healthy Women

Posted: Published on August 25th, 2018

The issue of hormone therapy to treat menopausal symptoms used to be a simple one. You had hot flashes, sleep disturbances, vaginal changesyou took hormones. Worried about your bones and heartyou took hormones. All that changed, of course, in the summer of 2002 with the announcement of the results of part of the Women's Health Initiative (WHI), the first-ever, long-term study of the effects of hormone therapy (HT) on postmenopausal women. One of the study's main goals was to investigate whether using estrogen (Premarin) or estrogen plus progestin (Prempro) as part of a hormone therapy regimen could prevent coronary heart disease in healthy women between the ages of 50 to 79. The investigators chose these two hormone products to study, because at the time they were the most-used form of hormone therapy. Researchers abruptly ended the Prempro arm three years early, because initial results showed an increased risk of breast cancer, heart disease, blood clots in the lungs and stroke in women taking hormone therapy. You know what happened nextmillions of women panicked, ditched their hormone therapy and frantically searched for options. A couple of years later, when the estrogen-only (Premarin) arm of the WHI found an increased incidence of … Continue reading

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Hormone Replacement Therapy | Optimal Health

Posted: Published on August 25th, 2018

Clinical scientific studies show HRT is not only effective, but when monitored, is safe for treating symptoms for both women and men. In addition, mounting evidence continues to show it is significantly life extending. Heres a simple explanation: as you age, your body may slow production of certain hormones. Hormone Replacement Therapy essentially makes up what your body no longer makes. Adding the hormones back allows key functions to continue versus abate. The Optimal Health Associates approach to Hormone Replacement Therapy is simple due to our vast experience. We determine the symptoms and correlate them to a thorough medical and laboratory evaluation. Each patient will then work with our team to find out exactly what is causing your symptoms. You will work with your provider to design a plan uniquely formulated to meet your specific needs. Hormones are chemicals made by the glands that act to control certain actions of cells and organs. In essence, hormones regulate your body's functions and keep things running smoothly. However, these hormones can become imbalanced or deficient in a condition known as hormone imbalance. Hormone replacement therapy is one type of treatment designed to correct this problem, but not all forms are created equally. … Continue reading

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Hypothalamic disease – Wikipedia

Posted: Published on August 23rd, 2018

Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by damage resulting from malnutrition, including anorexia and bulimia eating disorders,[1][2] genetic disorders, radiation, surgery, head trauma,[3] lesion,[1] tumour or other physical injury to the hypothalamus. The hypothalamus is the control center for several endocrine functions. Endocrine systems controlled by the hypothalamus are regulated by anti-diuretic hormone (ADH), corticotropin-releasing hormone, gonadotropin-releasing hormone, growth hormone-releasing hormone, oxytocin, all of which are secreted by the hypothalamus. Damage to the hypothalamus may impact any of these hormones and the related endocrine systems. Many of these hypothalamic hormones act on the pituitary gland. Hypothalamic disease therefore affects the functioning of the pituitary and the target organs controlled by the pituitary, including the adrenal glands, ovaries and testes, and the thyroid gland.[2] Numerous dysfunctions manifest as a result of hypothalamic disease. Damage to the hypothalamus may cause disruptions in body temperature regulation, growth, weight, sodium and water balance, milk production, emotions, and sleep cycles.[1][2][4] Hypopituitarism, neurogenic diabetes insipidus, tertiary hypothyroidism, and developmental disorders are examples of precipitating conditions caused by hypothalamic disease. The hypothalamus and pituitary gland are tightly integrated. Damage to the hypothalamus will impact the responsiveness and normal functioning … Continue reading

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