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Cardiac Repair and Regeneration Research Unit | Heart and …

Posted: Published on July 25th, 2018

DEB Laboratory Research Aims: We broadly investigate mechanisms of cardiac repair and regeneration and in particular study the interface of scar forming cells and cardiac progenitors in regulating a cardiac injury response. We use a variety of genetic, molecular and physiologic approaches to study how the outcome of a repair response can be manipulated to minimize scarring and enhance cardiac function. Main projects in the lab are summarized below: The heart is unable to regenerate heart muscle after a heart attack and lost cardiac muscle is replaced by scar tissue. Scar tissue does not contribute to cardiac contractile force and the remaining viable cardiac muscle is thus subject to a greater hemodynamic burden. Over time, the heart muscle eventually fails leading to the development of heart failure and 500,000 patients are diagnosed annually in the United States with heart failure. Thus the inability of the heart to regenerate cardiac muscle, coupled with a predominant fibrotic injury response remain major fundamental obstacles to treating heart disease. Our laboratory studies the interface of cardiac fibroblasts (scar forming cells) and cardiac progenitors in determining how a cross talk between these cells regulates cardiac repair. We use murine models of cardiac injury and use … Continue reading →

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Center for Hyperbaric Medicine – R Adams Cowley Shock …

Posted: Published on July 24th, 2018

Established in 1965, the Center for Hyperbaric Medicine at Shock Trauma is internationally recognized for its leadership and expertise in the clinical application of hyperbaric therapy. With the only multiplace hyperbaric chamber in the State of Maryland, the Center can accommodate up to 23 patients and care providers per dive. Conditions that are responsive to hyperbaric oxygen therapy include: Within this Center, recreational and commercial scuba divers can also undergo dive physicals to ensure they are healthy enough to dive. Specialists at the R Adams Cowley Shock Trauma Center are available for consultation and patient referral 24 hours a day, 7 days a week. Ambulatory patients are evaluated in Shock Trauma's Outpatient Clinic on a scheduled basis. Call University OneCall/Maryland ExpressCare at 1-800-373-4111 for easy access and no-hassle service. Robert E. Rosenthal, MD Chief, Hyperbaric MedicineProfessor of Emergency Medicine Special Interests: Hyperbaric Medicine; Wound Healing; Diving Injuries; Carbon Monoxide Poisoning; Radiation Tissue DamageMedical Degree: New York University School of Medicine, MDResidencies: George Washington University - Internal MedicineCertification: Emergency Medicine; Internal Medicine410-328-6152 / office Associate Director, Hyperbaric MedicineAssistant Professor of Emergency Medicine Special Interests: Wound Care; Carbon Monoxide Toxicity; Inflammation and Tissue DamageMedical Degree: University of Vermont College of MedicineResidency: Boston … Continue reading →

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Hyperbaric Oxygen Therapy – Montefiore Medical Center

Posted: Published on July 24th, 2018

The Hyperbaric Medicine Program at Montefiore, which emphasizes a focus on wound care, is a leading referral resource for hyperbaric medicine in New York. We heal chronic wounds and can often salvage limbs from risk of amputation, especially for patients who have compromised immune systems or diabetic foot ulcers. Hyperbaric Oxygen Therapy (HBOT) is a complementary treatment to overall wound therapy. During HBOT, a patient lies comfortably in an acrylic oxygen chamber and breathes 100 percent pure oxygen. This process helps fight infections, eliminates harmful toxins and promotes the growth of new blood vessels. These conditions are responsive to HBOT: Each patient at the Hyperbaric Medicine Program has a customized care plan developed by a multidisciplinary team of physicians, including: vascular surgeons, plastic surgeons, podiatrists, orthopedic surgeons, rehabilitative medicine experts, infectious disease specialists, nurses and technicians. We respond to the needs of the individual's wound before, during and after treatment. Each patient care plan includes a comprehensive approach to therapy and overall wound care as well as patient education. We assess the patient's baseline condition and determine if oxygen is critical to the healing of each wound. Our physicians also determine if the medical team can deliver enough oxygen to … Continue reading →

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Ventricular Remodeling | Profiles RNS

Posted: Published on July 24th, 2018

"Ventricular Remodeling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle. C23.300.985 G09.330.190.962.975 Below are MeSH descriptors whose meaning is more general than "Ventricular Remodeling". Below are MeSH descriptors whose meaning is more specific than "Ventricular Remodeling". This graph shows the total number of publications written about "Ventricular Remodeling" by people in this website by year, and whether "Ventricular Remodeling" was a major or minor topic of these publications. Below are the most recent publications written about "Ventricular Remodeling" by people in Profiles. Wenk JF, Klepach D, Lee LC, Zhang Z, Ge L, Tseng EE, Martin A, Kozerke S, Gorman JH, Gorman RC, Guccione JM. First evidence of depressed contractility in the border zone of a human myocardial infarction. Ann Thorac Surg. 2012 Apr; 93(4):1188-93. Xu EZ, Kantores C, Ivanovska J, Engelberts D, Kavanagh BP, McNamara … Continue reading →

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Ulcerative Colitis in Adults | American College of …

Posted: Published on July 24th, 2018

Asher Kornbluth, MD1, David B. Sachar, MD, MACG1 and The Practice Parameters Committee of the American College of Gastroenterology 1Dr. Henry D. Janowitz Division of Gastroenterology, Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA Am J Gastroenterol 2010; 105:501523; doi:10.1038/ajg.2009.727; published online 12 January 2010Received 2 February 2009; accepted 19 February 2009 Correspondence: Asher Kornbluth, MD, The Dr. Henry D. Janowitz Division of Gastroenterology, Samuel Bronfman Department of Medicine, Mount Sinai Medical Center, 1751 York Avenue, New York, New York 10128, USA. E-mail: asher.kornbluth@mssm.edu Am J Gastroenterol 2010; 105:500; doi:10.1038/ajg.2010.52; published online 23 February 2010 Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters CommitteeAsher Kornbluth, David B. Sachar and The Practice Parameters Committee of the American College of GastroenterologyAm J Gastroenterol 2010; 105:501523; doi:10.1038/ajg.2009.727 In the Conflict of Interest section of the article, the Financial Support subsection should have stated that No support was provided for this work. The publisher regrets any confusion this misstatement may have caused. The corrected Potential Competing Interests subsection for Dr Kornbluth is as follows: Asher Kornbluth is a consultant for Salix Pharmaceutical, Shire Pharmaceutical, Proctor and Gamble Pharmaceutical, Centocor, and Prometheus Laboratory and … Continue reading →

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Eczema herpeticum: Symptoms, diagnosis, and treatment

Posted: Published on July 24th, 2018

Welcome to Medical News Today Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current list) using cookies and similar automatic collection tools in order to a) personalize content and/or offers on our site or other sites, b) communicate with you upon request, and/or c) for additional reasons upon notice and, when applicable, with your consent. Healthline Media, Inc. is based in and operates this site from the United States. Any data you provide will be primarily stored and processed in the United States, pursuant to the laws of the United States, which may provide lesser privacy protections than European Economic Area countries. By clicking accept below, you acknowledge and grant your consent for these activities unless and until you withdraw your consent using our rights request form. Learn more in our Privacy Policy. Originally posted here: Eczema herpeticum: Symptoms, diagnosis, and treatment … Continue reading →

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CardioVascular Thoracic Institute (CVTI) | The most …

Posted: Published on July 23rd, 2018

Aortic AneurysmThe USC Comprehensive Aortic Center at the Keck Medical Center of USC was created to provide the best and most advanced care for patients with aortic disease, including aortic aneurysm, aortic dissection and genetic disorders. The Aortic Center employs the recognized expertise of our cardiac and vascular surgeons to provide the full complement of endovascular and open aortic procedures. The center has implemented a quick-response program, which provides emergency transport to Keck Medical Center for patients with emergencies. Learn more The USC Center for the Comprehensive Treatment of Atrial Fibrillation at Keck Medicine of USC comprises a multidisciplinary team of world-renowned heart rhythm specialists dedicated to the diagnosis and treatment of patients with atrial fibrillation. Our approach centers on the recognition that each patients condition is unique. Our model of care emphasizes the development of individualized patient treatment plans that incorporate state-of-the-art medical therapies for atrial fibrillation while striving to reduce or eliminate patient symptoms and decrease an individuals risk of stroke. We also offer full diagnostic services and treatment options via our USC Cardiology Program and USC Electrophysiology Program. Learn more Learn more about USC Cardiology. Learn more about the USC Electrophysiology Program. Learn more At the USC … Continue reading →

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Acute Management of Pulmonary Embolism – American College …

Posted: Published on July 17th, 2018

Introduction Venous thromboembolic disease (VTE) is estimated to occur in at least 1 to 2 persons per 1000 population annually, manifesting as deep vein thrombosis (DVT), pulmonary embolism (PE) or in combination.1-3 It is the cause of over 100,000 deaths annually and is the most preventable cause of death in hospitalized patients in the United States.4 Despite treatment with anticoagulant therapy, a significant proportion of survivors of acute DVT or PE are at risk of suffering from the disabling sequelae such as the post thrombotic syndrome (PTS), recurrent VTE or chronic thromboembolic pulmonary hypertension (CTEPH).1,5 Given the limitations of medical therapy, promising endovascular treatment modalities have evolved over the past two decades in an effort to mitigate the acute and chronic disability from VTE.6,7 The purpose of this review is to discuss the rationale and evidence for an endovascular treatment approach for high-risk acute DVT and PE patients. The Rationale for an Interventional Approach to Massive and Submassive PE The most dreaded acute complication of PE is death; it is estimated that over 100,000 deaths in hospitalized patients in the United States are attributable to acute PE each year.4 The severity of PE is stratified into massive (PE causing hemodynamic … Continue reading →

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EBR Systems, Inc

Posted: Published on July 17th, 2018

Allan Will, Chairman of the Board, President & CEO Allan is an operating executive with extensive experience founding, funding, operating, and selling medical device companies. Prior to EBR, he led negotiation of Ardians acquisition by Medtronic for over $800M. Will was also founding Managing Director, Split Rock Partners and a Partner at St. Paul Venture Capital. Previously, he was Founder, Chairman & CEO of The Foundry, co-founding 11 companies there including Ardian, Evalve (acquired by Abbott Laboratories for $450M) & Concentric Medical (acquired by Stryker for $135M). Previously, Will was CEO of AneuRx, acquired by Medtronic, growing to >$150MM the year of launch. In 1996 Will co-founded Adjacent Surgical, sold to GSII. Previously, he was President & CEO of Devices for Vascular Intervention, growing the business to 550 employees, $100MM revenue run rate, and acquisition by Eli Lilly. Will is an inventor on more than 30 issued patents, and has his M.S. in Management from MIT and his B.S. in Zoology from University of Maryland. Will has also served on MITs Entrepreneurship Center Shareholders Board, on the University of Maryland Presidents Committee on Innovation and Entrepreneurship and is a University of Maryland Distinguished Alumnus. Will was the recipient of the … Continue reading →

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Molecular Cardiology Centenary Institute

Posted: Published on July 16th, 2018

Molecular Cardiology is the study of genetic heart disorders. Our major goal is to reduce human disease through the integration of basic science research and clinical cardiology. Our research is focused on understanding the clinical and genetic basis of inherited heart disease. We use a range of approaches including human gene discovery studies, basic cellular systems, animal models of human disease, and population-based psychosocial and public health studies. Our research involves state-of-the-art approaches including whole exome sequencing, mRNA and microRNA profiling, and RNASeq. Most importantly, we have the key clinical resources, including well phenotyped individual patients and families, which form the basis of all our genetic studies. To get to this point, we have developed cohorts and national registries of patients and families with inherited heart diseases. We also utilise the latest in genetic technology in order to form the basis of our novel gene discovery studies. Around 30,000 Australians die every year from sudden cardiac death. Around four young Australians, under the age of 35, die every week from sudden cardiac death. We know that there are around 40 cardiovascular conditions caused by underlying genetic faults. We all have around 22,000 genes, but a fault in just one can … Continue reading →

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