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bioinformatics – NIH Common Fund

Posted: Published on September 6th, 2017

TheBioinformatics and Computational Biologyprogram, which supports the National Centers for Biomedical Computing, aims to develop novel, cutting-edge software and data management tools to effectively mine the vast wealth of biomedical data generated from sophisticated modern laboratory techniques and facilitate data sharing between researchers. Please note that since the Bioinformatics and Computational Biology program is no longer supported by the Common Fund, the program website is being maintained as an archive and will not be updated on a regular basis. Biology has always been a haven for microscopes, test tubes, and Petri dishes, but this conventional picture of the field is expanding rapidly. Sophisticated techniques adapted from physics, chemistry, and engineering enable scientists to use computers and robots to separate molecules in solution, read genetic information, reveal the three-dimensional shapes of natural molecules like proteins, and take pictures of the brain in action. All of these techniques generate large amounts of data, and biology is changing fast into a science of information management. Today's biomedical researcher routinely generates an amount of data that would fill multiple compact discs, each containing billions of bytes of data. (A byte is approximately the amount of information contained in an individual letter of type on … Continue reading

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Undergraduate bioinformatics major launches fall 2017 – Marquette Wire

Posted: Published on September 6th, 2017

Close Serdar Bozdag, assistant professor in the department of MSCS, discussing the new program. Photo by Andrew Himmelberg Photo by Andrew Himmelberg Serdar Bozdag, assistant professor in the department of MSCS, discussing the new program. Bioinformatics, acombination of biology and data analysis, is now available as a major to Marquette undergraduate students. The university launched the new bioinformatics program this fall, jointly-housed by the department of Biological Sciences and the department of Mathematics, Statistics and Computer Science. Bioinformatics was born from the massive amount of biological data that need to be analyzed, saidProfessor Edward Blumenthal, chair of the department of Biological Sciences. Biologists are not trained in how to deal with these data sets. We can generate them, we can collect the data, but we are not trained in the statistics and the computer science in order to analyze them and get the meaning, Blumenthal said. Then youve got computer scientists who are trained at how to analyze these data sets, but they dont necessarily know the biology. Bioinformatics was introduced to produce people who are proficient in both the fields of biology and data analysis,Blumenthal said. Despite the separation of the departments that deal with bioinformatics, the program emerged … Continue reading

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Spreading depolarizations trigger early brain injury after subarachnoid hemorrhage, researchers find – Medical Xpress

Posted: Published on September 6th, 2017

The study of Hartings and colleagues found that bleeding onto the surface of the brain (a subarachnoid clot) can directly cause the death (infarct) of the affected brain gray matter the cerebral cortex. Progression to death is mediated by repetitive brain tsunamis (cortical spreading depolarizations), shown here by blue waves and arrows, that spread through the cortex. Brain tsunamis reduce blood supply to the brain (cortical spreading ischemia) and impair brain function, resulting in flatline (terminal depolarization) as the tissue dies. Brain tsunamis were first described in 1944 by Aristides Leo and today are measured in patients with electrodes placed on the brain surface. Credit: Illustration by Tonya Hines, Mayfield Clinic The phrase "time is brain" could take on new meaning when applied to the treatment of subarachnoid hemorrhage, a type of bleeding stroke, thanks to research partially funded by the Mayfield Education & Research Foundation and the United States government. Subarachnoid hemorrhage, caused by the rupture of a brain aneurysm, affects an estimated 10 to 15 of every 100,000 individuals each year. An international team of researchers has established that the blood from this type of hemorrhage launches deadly "brain tsunamis" within hours, leading to permanent brain damage. This … Continue reading

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Carlson offers veteran a new start after brain injury – Minnesota Daily

Posted: Published on September 6th, 2017

On March 19, 2012, Brian Grundtner fell 50 feet during an airborne training jump, sustaining multiple broken bones and a traumatic brain injury. Four years later, the former special operations staff sergeant overcame his TBI to graduate from the Carlson School of Management with his Masters of Business Administration. Grundtner, a native of White Bear Lake, Minnesota, said he chose the University for its military veterans MBA program. I think the biggest factor for me was the veterans initiative and the emphasis on integrating veterans into the whole MBA program, Grundtner said. It really helped with the transition out of the military and into the civilian world. Retired naval officer Charles Altman, the MBA military veterans program director, said financial assistance make the University's one of the best programs for veterans. Twenty percent of Carlsons full-time MBA students are veterans and all of them get scholarships, Altman said. Those who complete the program have a 100 percent employment rate after graduation. In a lot of cases what veterans need more than anything else is a leg up this funding provides them that, Altman said, adding he spent time getting to know Grundtner while he was a student. Dave Hopkins, a … Continue reading

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This Is Why You Want to Steer Clear of Antidepressants If You Have Alzheimer’s – Reader’s Digest

Posted: Published on September 6th, 2017

Photographee.eu/ShutterstockSome of the early symptoms of Alzheimers Disease are the same as those of depression, including apathy and irritability. As a result, many patients with Alzheimers Disease (AD) are prescribed antidepressant medications. A group of scientists from the University of Eastern Finland were concerned that this practice could be increasing the risk of head and brain injuries among AD patients. Heres why: First, AD is a disease associated primarily with the elderly. Second, antidepressant use among the elderly is associated with an increased risk of falling down. Finally, falling down is the number one cause of head and brain injuries in the elderly (compare this to younger people, who more often experience head injuries as a result of motor vehicle, sports, and other accidents). Since there were no existing studies investigating the risk of head or brain injuries associated with antidepressant use, let alone studies that focused on the AD patients or even the elderly, the Finnish scientists took it upon themselves to investigate whether antidepressant use is associated not only with an increased risk of falling, but also with an increased risk of head and brain injury in Alzheimers patients. What they found is that the use of antidepressants … Continue reading

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How to avoid, recognize and treat concussion in sports – National Post

Posted: Published on September 6th, 2017

This article was originally published on The Conversation, an independent and nonprofit source of news, analysis and commentary from academic experts. Disclosure information is available on the original site. Author: Kathryn Schneider, Assistant Professor, Clinician Scientist (Physiotherapist), Faculty of Kinesiology, University of Calgary Recognize, remove, rest and recover before returning to sport. Those are key points about sport-related concussion stated in the 5th International Consensus Statement on Concussion in Sport. The Canadian Guidelines on Concussion in Sport have been developed based on this statement and were recently released by Parachute Canada, a charitable organization focused on injury prevention, and its expert advisory group. The good news is that most people who suffer a concussion will recover in the initial days and weeks following injury. However, some will have ongoing symptoms. While concussions may occur in sport, there are many benefits to physical activity and sport participation for both youth and adults. I am a physiotherapist and researcher (assistant professor and clinician scientist) at the Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary. My research focuses on the prevention and treatment of sport-related concussion in children, youth and adults, with special emphasis on the role of the neck … Continue reading

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New AstraZeneca, Amgen Biotech Drug Offers Broad Asthma Relief – New York Times

Posted: Published on September 6th, 2017

Injections for severe asthma have opened up a multibillion-dollar market as competing drugmakers have raced to develop antibody-based medicines for the 15 percent or more of patients who do poorly even on the latest inhalers. Despite treatment advances in recent decades, their asthma is still not well controlled by standard therapy, which consists of inhaled steroids and drugs to open the airways. Nucala and Teva's Cinqair are two recently approved new injectable drugs and AstraZeneca's benralizumab is likely to join them soon, since it is awaiting approval in the fourth quarter of this year. Sanofi's Dupixent, already approved for severe eczema, is a bit further behind but is widely seen as a strong contender. However, all these new medicines only appear to help people with certain types of severe asthma, by targeting specific inflammatory chemicals made in the body that drive asthma, making them suitable for subgroups of patients. Tezepelumab is different because it acts further upstream in the inflammatory cascade responsible for asthma by blocking the action of a cell-signalling protein called thymic stromal lymphopoietin (TSLP). That means it can help a wider range of patients and could be a "game-changer", according Tom Keith-Roach, head of AstraZeneca's respiratory, inflammation … Continue reading

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Shares of Sarepta Therapeutics soar on positive drug study results – CNBC

Posted: Published on September 6th, 2017

Shares of Sarepta Therapeutics soared 12 percent in early trading Wednesday after the biopharmaceutical company reported positive results from a clinical trial of an experimental medicine for Duchenne muscular dystrophy. The drug, golodirsen, would be Sarepta's second to treat the rare, genetic disease, which causes muscle wasting and can be fatal before patients turn 30. Sarepta focuses on the discovery and development of precision genetic medicines to treat rare neuromuscular diseases. The new study, conducted in Europe, involved 25 boys with confirmed deletions of the DMD gene amenable to skipping exon 53. Exons are part of the DNA code. The treatment targets a genetic mutation affecting about 8 percent of patients with DMD. Sarepta's first drug for DMD, Exondys 51 approved on a conditional basis by the FDA last year pending more testing to confirm results treats a mutation affecting about 13 percent. Exondys 51 costs about $300,000 per year. "Our goal is to treat 100 percent" of DMD suffers, Sarepta CEO Doug Ingram told CNBC's "Squawk Box." "The data that we have this morning shows we're on the right path." The results, announced before Wall Street's open bell, showed that golodirsen increased production of the protein dystrophin to 1.02 … Continue reading

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Early movers: XOM, SRPT, NAV, HDS, NWL, TRVG, GIII, HPE & more – CNBC

Posted: Published on September 6th, 2017

Check out which companies are making headlines before the bell: Exxon Mobil UBS upgraded the stock to "neutral" from "sell," noting the underperformance of the stock this year and an improved macro outlook for the oil industry. Sarepta Therapeutics The drugmaker announced positive study results for a new treatment for Duchenne Muscular Dystrophy. Navistar The truck and engine maker earned 37 cents per share for its latest quarter, beating estimates by nine cents a share. Revenue also topped forecasts. The return to profitability for Navistar comes as it increases market share and profit margins. HD Supply Holdings The industrial distributor matched forecasts with adjusted quarterly profit of 64 cents per share, with revenue very slightly above Street projections. Newell Brands The consumer products maker cut its full-year forecast, due to the impact of Hurricane Harvey on its resin suppliers. Newell's Rubbermaid division is among its substantial users of resins. Trivago The travel website operator cut its full-year outlook, based on slower-than-expected revenue growth. Trivago said revenue per qualified referral a key metric fell too quickly to prevent overspending on ad purchases. G-III Apparel The manufacturer of licensed apparel lost 18 cents per share for its latest quarter, eight cents a … Continue reading

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Mid-Afternoon Market Update: Crude Oil Up Over 1%; Sarepta Shares Jump After Positive Results In DMD Treatment … – Benzinga

Posted: Published on September 6th, 2017

Toward the end of trading Wednesday, the Dow traded up 0.42 percent to 21,845.34 while the NASDAQ climbed 0.41 percent to 6,401.95. The S&P also rose, gaining 0.42 percent to 2,468.27. Leading and Lagging Sectors Wednesday afternoon, the energy shares surged 1.23 percent. Meanwhile, top gainers in the sector included Frontline Ltd. (NYSE: FRO), up 5 percent, and JA Solar Holdings Co., Ltd. (ADR) (NASDAQ: JASO), up 6 percent. In trading on Wednesday, utilities shares fell 0.25 percent. Meanwhile, top losers in the sector included NRG Energy Inc (NYSE: NRG), down 3 percent, and Entergy Corporation (NYSE: ETR) down 1 percent. Top Headline G-III Apparel Group, Ltd. (NASDAQ: GIII) reported stronger-than-expected results for its second quarter and raised its FY18 forecast. G-III Apparel reported a Q2 adjusted loss of $0.15 per share on revenue of $538 million. However, analysts were expecting a loss of $0.26 per share on sales of $522 million. Equities Trading UP Verastem Inc (NASDAQ: VSTM) shares shot up 30 percent to $5.00 after the company disclosed that its Phase 3 DUO study evaluating the efficacy and safety of duvelisib showed statistically significant improvement. Shares of Voyager Therapeutics Inc (NASDAQ: VYGR) got a boost, shooting up 20 … Continue reading

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