For more than 17 million people in the United States living with severe eczema a condition that results in dry, itchy rashes and disqualifies many from military service the mystery behind its cause may be all too familiar. Thanks to researchers at the Uniformed Services University of Health Sciences and National Institutes of Health, certain patients may understand more about their condition. Studying these disorders, especially when we can define the disease based on a single mutation, is incredibly informative because you can learn a lot, said Andrew Snow, assistant professor in the department of pharmacology and molecular therapeutics at USU, and senior co-author of a study recently published in the journal Nature Genetics. In this study, mutations in a gene known as CARD11 were identified as one underlying cause for severe eczema. The discovery led the researchers to ask whether excess glutamine can help correct some of the allergy-related defects in patients immune cells. The testing was done with T cells, known as the conductors of the bodys immune response against infections, from one patient in a lab, and the results were promising. Additional work with the NIH to study whether symptoms for patients with similar mutations improve with … Continue reading
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