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It’s Not a Rat’s Race for Human Stem Cells Grafted to Repair Spinal Cord Injuries – UC San Diego Health

Posted: Published on August 29th, 2017

More than one-and-a-half years after implantation, researchers at University of California San Diego School of Medicine and the San Diego Veterans Administration Medical Center report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting. The findings are published in the September issue of the Journal of Clinical Investigation. The NSCs retained an intrinsic human rate of maturation despite being placed in a traumatic rodent environment, said Paul Lu, PhD, associate professor of neurosciences and lead author of the study. Thats a finding of great importance in planning for human clinical trials. Neural stem cells differentiate into neurons and glia or support cells. Researchers like Lu and colleague, Mark Tuszynski, MD, PhD, professor of neuroscience and director of the UC San Diego Translational Neuroscience Institute, have explored their potential as a sort of patch and remedy for spinal cord injuries, implanting NSCs derived from induced pluripotent stem cells into animal models of spinal cord injuries to repair damage. In previously published animal studies, Lu and Tuszynski have shown NSCs can survive implantation and make new connections, even beginning to restore limited physical function, … Continue reading

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Lynchburg fire captain spearheads calendar featuring ladies of the LFD – Lynchburg News and Advance

Posted: Published on August 29th, 2017

Endurance, strength, enthusiasm, persistence those are some of the key themes of the retro-styled Women of the Lynchburg Fire Department calendar that will bring some Lynchburg firefighting flair to peoples walls in 2018 and 2019. Abbey Johnston, a captain whos been with the Lynchburg Fire Department for 13 years, said the 18-month calendar hits a number of highlights for the department. For one, she said its the first time the department has had enough women to feature in a calendar all 14 who were employed at the time of the photo shoots are included in the calendar. Two more have joined the department since. Not everyone was all in for the calendar at first, though. Johnston said some firefighters or their families had reservations about the proposed pin-up nature of the photos. But, as Johnston assured them, the pictures would be fashionable and feminine, yet classy, with a retro, 1950s feel. We wanted it to be respectful, she said. We wanted it to focus on strength, the different strengths that it takes to do the job, and to be honorable to all of our members: retired and current, male and female. Other women featured in the calendar include administrative personnel … Continue reading

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Around the web: Concerns with human genetic engineering, Gary … – American Enterprise Institute

Posted: Published on August 28th, 2017

Should we welcome human genetic engineering? Tyler Cowen If you could directly alter your kids genetic profile, what would you want? Its hard to know how the social debate would turn out after years of back and forth, but I was dismayed to read one recent research paper by psychologists Rachel M. Latham and Sophie von Stumm. The descriptive title of that work, based on survey evidence, is Mothers want extraversion over conscientiousness or intelligence for their children. Upon reflection, maybe that isnt so surprising, because parents presumably want children who are fun to spend time with. Would a more extroverted human race be desirable, all things considered? I genuinely dont know, but at the very least I am concerned. The current mix of human personalities and institutions is a delicate balance which, for all of its flaws, has allowed society to survive and progress. Im not looking to make a big roll of the dice on this one. Amazon robots bring a brave new world to the warehouse The Financial Times Another way to look at US wage growth The Financial Times The robot tax gains another advocate Wired Kim got the idea of a robot tax from Bill … Continue reading

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Genetic engineering: upgrading to human 2.0 – T3

Posted: Published on August 28th, 2017

There are two ways to upgrade a human - tinker with biology or augment with technology. So when the time comes to upgrade to human 2.0, should we become Bioshock-style splicers or Halo-esque spartans? This week we look at the science behind a genetic boost. Science fiction isnt afraid to mess with genetics. Bioshocks ADAM is a syrup of stem cells augmented with plasmids that carry superhuman genetic traits. Preys Neuromod enhances cognitive abilities by splicing alien genetics into viruses delivered directly into the brain through the eyes. And Prototype's Blacklight gets in to cells and tweaks their genetic code, activating and editing dormant sequences. So how close are we to game-changing genetic upgrades? (Image: I.C. Baianu et al.) The genetic revolution started in the 1950s with two wily Cambridge scientists. With data nabbed from colleagues in London, Watson and Crick deciphered the structure of DNA and opened Pandoras box. Since then, the field has moved fast, and it's littered with Nobel Prizes. By the mid 1970s, scientists had discovered DNA-snipping molecular scissors known as restriction enzymes, and DNA-stitching enzymes called ligases. It became possible to cut and splice the genetic code, stitching components from different organisms to create recombinant … Continue reading

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The drive for the perfect offspring can get scary – Chicago Tribune

Posted: Published on August 28th, 2017

There's a lot of innovation going on in China these days, but perhaps not all of it is good. Chinese fertility centers are going well beyond American practices, using genetic diagnosis to influence how children conceived through in vitro fertilization will turn out. On one hand, the potential for improving human health is enormous. On the other hand, I am uneasy at the prospect of the power this gives parents. I don't trust people to take so much control over the future of human nature. Sometimes you hear it argued that the complex nature of genes will prevent major feats of genetic engineering. That may be selling short future advances in Big Data and biomedicine, but even minor changes in genetic diagnosis and selection could have significant effects. Maybe you can't choose to have a child who will be happy, but you might be able to lower the chance of your kid having depression or social anxiety by some small amount. Over the course of generations, that will exert great influence over the nature of the human experience. One risk, of course, is that parents will opt for some apparently desirable qualities in their children, and then the experiment will … Continue reading

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Activists criticise recommendation on GM mustard by Genetic … – The New Indian Express

Posted: Published on August 28th, 2017

NEW DELHI: Activists today criticised the biotech regulator GEAC's decision to recommend commercial use of genetically modified mustard in a submission to the environment ministry. Coalition for a GM-Free India said it is no coincidence that credible committees are asking to stop the introduction of GM crops. Their comments came a day after a parliamentary panel said that no GM crop should be introduced in India unless the bio-safety and socio-economic desirability is evaluated in a "transparent" process and an accountability regime is put in place. The department-related parliamentary standing committee on science and technology and environment and forest chaired by Congress leader Renuka Chowdhury made its recommendations in its 301st report on 'GM crop and its impact on environment'. The panel's comment came in the wake of India's GM crop regulator Genetic Engineering Appraisal Committee (GEAC) recently recommending the commercial use of genetically modified mustard in a submission to the environment ministry. The coalition said the latest report is a reiteration in many ways of what earlier committees like the Parliamentary Standing Committee on Agriculture (2012 and 2013) had said as well as the majority report of the Supreme Court's Technical Expert Committee (2013). "The fact that certain unacceptable … Continue reading

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Clinic helps Lily walk – Bendigo Advertiser

Posted: Published on August 28th, 2017

Every six months, Bendigos Lily-Rose Sparkes dons a happy mask. ALL SMILES: Five-year-old Lily-Rose Sparkes with Associate Professor Adam Scheinberg at Bendigo Health. Picture: DARREN HOWE Lily-Rose Sparkes, 5, with Associate Professor Adam Scheinberg. Picture: DARREN HOWE Lily-Rose Sparkes, 5, with Associate Professor Adam Scheinberg. Picture: DARREN HOWE Lily-Rose Sparkes, 5, with Associate Professor Adam Scheinberg. Picture: DARREN HOWE Every six months, BendigosLily-Rose Sparkes dons a happy mask as she undergoes treatment to allow her to walk properly. The bubblyfive-year-old says as she goeson tippy toes she has to visit the hospital, where doctors give her a mask for happy gas and follow through with a series of injections in her calves to help her walk. Lily has cerebral palsy and has been receivingbotulinum toxintreatments since she was two years old. Mum,Mia Smith, said they first realised Lily was having trouble about six months after she started to walk. Without this treatment, she wouldnt be able to walk correctly, she said. She would be always walking on her tippy toes and wouldnt be able to climb or do some of the basic things people think kids can just do. Ms Smith said the treatments gave Lilythe opportunity to be able … Continue reading

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A New Way for Doctors to Share Their Medical Mysteries – WIRED

Posted: Published on August 28th, 2017

In Gerald Grants line of work, there isnt such a thing as an average patient. As a chief of pediatric neurosurgery at Stanford University Medical Center, the children that come into his operating room are unique, each requiring a complex surgical procedure tailored to the architecture of a young brain. But that doesnt mean he cant learn from what other people have done. Grants always searching for similar cases to give his patients the best possible shot. And more and more hes finding those answers not in prestigious, paywalled publications like the Journal of Neurosurgery (of whose editorial board he is a member), but on the freely available pages of an upstart publishing platform modeled after, of all things, Turbotax. The Cureus Journal of Medical Science (thats pronounced curious) is the brainchild of one of Grants colleagues at Stanford, a fellow neurosurgeon named John Adler. Hes on a mission to build the worlds most comprehensive library of medical case studies. Cureus is the first and only peer-reviewed publication with step-by-step article templates for authorswhich dramatically speeds up publication times. (Just like your tax software!) If case studies are published in weeks instead of months, that means millions more medical lessons … Continue reading

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UT Southwestern Research Reveals Dual Benefits in Vitamin C for Cell Function, Cancer Prevention – D Healthcare Daily

Posted: Published on August 28th, 2017

Childrens Medical Center Research Institute at UT Southwestern researchers have discovered that stem cells absorb unusually high levels of vitamin C, which reportedly regulate function and suppress the development of leukemia. While research currently shows people with lower levels of vitamin C are at increased risk for cancer, this study indicated why vitamin C is inherently important for the blood-forming system by routinely measuring metabolite levels in stem cell populations. The techniques used in the study led researchers to find that every type of blood-forming cell in the bone marrow had distinct metabolic signaturestaking up and using nutrients in their own individual way. To further understand vitamin Cs importance in stem cell function, researchers tested mice that lacked the enzyme used to synthesize vitamin C in order to see its effects when added. According to the research, scientists controlled the vitamin C intake on mice so that they could only obtain the supplement exclusively through their diet, like humans do. They tested mice absorbing vitamin C levels seen in 5 percent of healthy humans. To the researchers surprise, the depletion of vitamin C meant the stem cells gained function, but also increased the mices chances of leukemia. Dr. Michalis Agathocleous, … Continue reading

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What is brain pressure? Symptoms of life-threatening intracranial hypertension revealed – Express.co.uk

Posted: Published on August 28th, 2017

Chronic IH can result in a blood clot on the brain, a brain tumour, a brain infection or a blood clot on the brain. It can be life threatening if it is not diagnosed or treated. Idiopathic Intracranial Hypertension - also known as IIH mainly affects women in their 20s and 30s and has been linked to being overweight, hormone problems such as Cushings syndrome, taking the contraceptive pill, lack of red blood cells, lupus and kidney disease. The cause of the condition is unclear. Symptoms of chronic IH can include a constant headache - which can be worse in the morning and can occur while coughing, blurred or double vision, temporary loss of vision, feeling and being sick, drowsiness and irritability. If IH comes on suddenly, it could be as a result of stroke, severe head injury, or a brain abscess. Scientists have now discovered common obesity and diabetes drug reduces rise in brain pressure. New research Research led by the University of Birmingham, published in Science Translational Medicine, has discovered that a drug commonly used to treat patients with either obesity or Type 2 diabetes could be used as a new new way to lower brain pressure. IHH … Continue reading

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