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Bacterial infection stresses hematopoietic stem cells – Medical Xpress

Posted: Published on August 24th, 2017

Bacterial infection activates hematopoietic stem cells in the bone marrow and significantly reduces the ability to produce blood through induced proliferation. Credit: Professor Hitoshi Takizawa It has been thought that only immune cells would act as the line of defense during bacterial infection. However, recent research has revealed that hematopoietic stem cells, cells that create all other blood cells throughout an individual's lifetime, are also able to respond to the infection. A collaboration between researchers from Japan and Switzerland found that bacterial infection activates hematopoietic stem cells in the bone marrow and significantly reduces their ability to produce blood by forcibly inducing proliferation. These findings indicate that bacterial infections might trigger dysregulation of blood formation, such as that found in anemia or leukemia. This information is important to consider in the development of prevention methods for blood diseases. Background: Bacterial Infection and the Associated Immune Reaction When a person becomes infected with a virus or bacteria, immune cells in the blood or lymph react to the infection. Some of these immune cells use "sensors" on their surfaces, called Toll-like receptors (TLR), to distinguish invading pathogens from molecules that are expressed by the host. By doing so, they can attack and … Continue reading

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ImmunoCellular Plans Job Cuts in Shift to Stem-to-T-Cell Program – Genetic Engineering & Biotechnology News (press release)

Posted: Published on August 24th, 2017

Two months after winding down development of its lead candidate for lack of funds, ImmunoCellular Therapeutics says it will cut jobs and facilities in a restructuring designed to lower costs and refocus the company on its program to generate cancer-killing T cells by engineering hematopoietic stem cells. The company gave no details on how many jobs will be eliminated or which facilities would be jettisoned in a statement yesterday. ImmunoCellular has seven full-time and two part-time employees, according to its Form 10-Q for the second quarter, filed August 14. The board and management of ImmunoCellular remain committed to pursuing a viable strategic path forward for the Company, with the goal of realizing the value of our immuno-oncology technology platform and assets, stated ImmunoCellular president and CEO Anthony J. Gringeri, Ph.D. To that end, ImmunoCellular said, it will shift its attention to developing its Stem-to-T-Cell research program, which could potentially treat both solid and blood tumors. Stem-to-T-Cell uses the immune system to manufacture antigen-specific killer T cells that target and destroy cancer cells, as well as prevent tumor recurrence through long-term immunosurveillance. Stem-to-T-Cell is expected to achieve two milestones by years end: During the third quarter, ImmunoCellular anticipates completion of loading … Continue reading

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North Carolina Advances in Stem Cell Therapy for Lung Diseases Could Lead to Clinical Trial Soon – Lung Disease News

Posted: Published on August 24th, 2017

University of North Carolina Health Careresearchers have made strides toward a stem cell treatment for lung diseases such as pulmonary fibrosis, COPD, and cystic fibrosis. In fact, they are discussing the start of clinical trials with regulatory authorities. The team discussed its work in two recent studies. One provedthat it is possible to isolate lung stem cells with a relatively non-invasive procedure. The other showed that stem cells reduce fibrosis in rats with pulmonary fibrosis. The first study, in the journal Respiratory Research, was titledDerivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies.The second, inStem Cells Translational Medicine, was Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis. This is the first time anyone has generated potentially therapeutic lung stem cells from minimally invasive biopsy specimens, Dr. Jason Lobo, director of the universitys lung transplant and interstitial lung disease program,said in a press release. Hewas co-senior author of both studies. We think the properties of these cells make them potentially therapeutic for a wide range of lung fibrosis diseases, added Dr. Ke Cheng, who led the studies with Lobo. He is anassociate professor in North Carolina State Universitys Department of … Continue reading

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Ulcerative colitis breakthrough: THIS test for bowel disease could revolutionise diagnosis – Express.co.uk

Posted: Published on August 24th, 2017

In ulcerative colitis, tiny ulcers develop on the surface of the lining of the large bowel. Experts believe a fast, simple test for ulcerative colitis could provide a cheaper less invasive alternative for screening. A colonoscopy is currently the main test for the condition. Research by the Department of Physics and Astronomy and the Institute for Biomedical Sciences at Georgia State University found the testing procedure could more easily screen patients for ulcerative colitis. A colonoscopy is a test which allows a doctors to look at the inner lining of the large intestine - which includes the rectum and colon, every five years or more frequently if abnormalities are found. The test can help find ulcers, colon polyps, tumour and other areas of inflammation. However, the procedure is uncomfortable and can also be expensive. Experts said there was a need to be able to diagnose inflammatory bowel disease more effectively. Dr A G Unil Perera, Regents' Professor of Physics, said: Colonoscopy is used as a screening technique, so even if you dont know if a person has colitis or not, thats the only way to check and say they do. We are not talking about replacing colonoscopy. We have shown … Continue reading

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Takeda Asks Japanese Regulators to Approve Vedolizumab as an Ulcerative Colitis Treatment – IBD News Today

Posted: Published on August 24th, 2017

Takeda Pharmaceutical Companyhas submitted a new drug application to Japanese regulators for vedolizumab (MLN0002) as a treatment for adults with moderate to severe ulcerative colitis. Ulcerative colitis is a chronic, progressive inflammatory disease of the large intestine, which typically affects young adults,Toshiro Heya, head of Takeda Development Center Japan, said in a press release. The disease has a high impact on their quality of life, with symptoms including diarrhea, rectal bleeding, incontinence and abdominal pain.Through this submission [new drug application], we may provide an alternative treatment option to the increasing number of people with UC in Japan. In Japan, the agency that approves new drugs is theMinistry of Health, Labor and Welfare. Two Phase 3 clinical trials showed vedolizumab to be effective against ulcerative colitis. CCT-101 (NCT02039505) was a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. It looked at the effectiveness, safety, and pharmacokinetics of vedolizumab in 292 Japanese patients with moderate or severe ulcerative colitis.Pharmacokinetics refers to the bodys effect on a drug. Takeda plans to present the trial results at a scientific conference. GEMINI I (NCT00783718) was an international, randomized, double blind, placebo-controlled trial that assessed vedolizumabs effectiveness in 895 patients with moderate to severe ulcerative colitis. We aim … Continue reading

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Melvindale student embraces challenges of chemistry at BASF summer science program – Southgate News Herald

Posted: Published on August 23rd, 2017

Learning doesnt have to take a vacation during the summer, as Allison Filipowski discovered after attending the seventh annual BASF Science Academy. The Melvindale High School student jump-started her college experience and learned the business of chemistry at the companys two-week advanced level science program. Filipowski was among 20 high school seniors who earned the opportunity to participate in the program designed to prepare students for a career in science, technology, engineering or math. The summer science program, developed by BASF Corp., is held at Fairleigh Dickinson University in Madison, N.J. Working in teams, students use BASF chemistry to formulate their own personal care products and develop a go-to-market plan and strategy. At the end of the program, students present their product to a panel of BASF executives and FDU academic leaders. Providing students access to high-quality learning opportunities in STEM is a priority, said Greg Pflum, vice president and general manager for BASFs Midwest Hub in Wyandotte. This two-week academy continues to play an important role in the students enduring appreciation of science and will serve as an inspiration to pursue higher education and a career in STEM. Following the curriculum theme, From Molecules to Marketplace, students gained invaluable … Continue reading

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Frank Reich addresses Torrey Smith and Carson Wentz’s chemistry … – Eagles Wire

Posted: Published on August 23rd, 2017

We havent heard much about Torrey Smith this preseason. A lot of the wide receiver talk has been dominated by Alshon Jefferys chemistry with Carson Wentz or what happens to Nelson Agholor and Mack Hollinsfollowing the Jordan Matthews trade. Smith hasnt caughtone pass in either of the two Eagles preseason games thus far. Is there a chemistry problembetween Smith and Wentz? Absolutelynot. Offensive coordinator Frank Reich debunked that idea completely when asked about that on Monday after practice. I think their chemistry is good, Reich said. Torrey is a pro. He works very hard. I think theyve gotten a lot of reps together all through OTAs and training camp. So [I am] not concerned about the production in the preseason game where he really hasnt played that much. So [I] feel very good about that. And Reich doesnt think that preseason games dictate the amount of chemistry a QB and WR share. You have to throw deep balls, Reich said. I mean, you dont just say, Okay, hes a fast guy, just throw it deep. There is a chemistry, a timing and a feel to that. But I think theyve gotten a lot of that in OTAs and training camp, … Continue reading

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DNA expert opens Windward CC’s chemistry forum series – UH System Current News

Posted: Published on August 23rd, 2017

David Haymer DNA expert and Hawaii Innocence Project consultant David Haymer will discuss new methods of DNA analysis as part of the Community Forum in Chemistry series at Windward Community College on Thursday, September 14, 12 p.m. at Hale Imiloa 111. Haymer, who obtained his doctoral degree from Purdue University, is a professor of cell and molecular biology at the University of Hawaii at Manoa John A. Burns School of Medicine. With more than 25 years of experience with DNA analysis, he is the DNA consultant of the Hawaii chapter of the Innocence Project. The Innocence Project is a non-profit legal organization aimed to exonerate the wrongfully convicted through the use of new DNA-based methods. DNA evidence is now commonly introduced in criminal investigations by both prosecuting and defense attorneys. The forum is free and open to the public. Parking is free. The Community Forum in Chemistry is co-sponsored by Windward Community College and the American Chemical Society-Hawaii Section. For more information, call Letty Colmenares, professor of chemistry at Windward CC at (808) 236-9120. Read more: DNA expert opens Windward CC's chemistry forum series - UH System Current News … Continue reading

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Dolphins Practice Report: Cutler Developing Chemistry With Offense, Pouncey To Start Thursday – CBS Miami

Posted: Published on August 23rd, 2017

Follow CBSMIAMI.COM:Facebook|Twitter PHILADELPHIA (CBSMiami) The Miami Dolphins and Philadelphia Eagles completed the second day of their joint practices on Tuesday. Now the teams will go their separate ways begin their final preparations for Thursdays preseason battle at Lincoln Financial Field. With the joint workouts now over, both teams can breathe a sigh of relief that no players on either side suffered any major injuries. There was one little scare for the Dolphins that turned out to be no big deal. Rookie cornerback Condrea Tankersley left the practice field accompanied by a trainer, though he did not appear to be in any discomfort. Head coach Adam Gase later revealed that Tankersley came out because he was sick. THE CUTLER CONNECTION Quarterback Jay Cutler had perhaps his best day of practice since joining the Dolphins. He connected with several of his pass catchers for touchdowns, including a pair of 40 yard bombs to Kenny Stills and DeVante Parker. Were getting better every day, so weve just got to continue to work before practice, in the meeting rooms, after practice, and get on the same page, Stills said. Hes a veteran guy and weve just got to go out there and make plays … Continue reading

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Sean McDermott enhances Bills’ team chemistry by creating ‘campfires’ – Bills Wire

Posted: Published on August 23rd, 2017

Its no secret Buffalo Bills coach Sean McDermott is big on building team chemistry through a variety of means. The most recent way hes done so is by moving players around the locker room. Players are no longer assigned lockers by position groups as done in the past. McDermotts been doing this since the beginning of off-season workouts and believes that by doing so it encourages members of the team to get to know one another better. Players who ordinarily wouldnt spend much time together find themselves sharing a locker next to one another. McDermott believes the results have been positive so far. Heres what McDermott had to say about the process after being asked by reporters if he liked the results. I have liked the results. It was, and still is, a team-building concept. I want to make sure that we spend so much time in a lot of little campfires. Youve got a campfire with the linebacking corps, youve got a campfire with the offense, a campfire over here with the defense, with the special teams, that as we continue to build this team and bring things together to one cohesive campfire, if you will in this case, … Continue reading

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