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Grasping genetics: ‘Improved’ animals are like elite athletes or racing cars – FeedNavigator.com

Posted: Published on August 15th, 2017

Industry needs to better understand the genetic differences behind high performing, selectively bred animals when developing feed, say scientists. Animals can be selectively bred to grow faster, grow to a specific size or even digest food better, among other things, but what most programs all have in common is the goal of feed efficiency. Dr Kim Bunter, senior scientist for the Animal Genetics and Breeding Unit at University of New England, Australia, said it was vital feed manufacturers and others working with these improved animals, better understood animal genetics. If you dont understand genetics, you tend to have the global view that one diet fits all, at least within a class of animals, she told FeedNavigator. If you understand genetics, or even just the nature of variation between individuals - whether it be genetic or environmental in origin, then perhaps targeted or customized diets for animals would have more meaning. Bunter said that whilst the animal sector had customized diets for classes of animals with differences in weaner, grower and lactation diets, for example industry had yet to truly customize for high performing animals within that class. Animal longevity, she said, was an issue across industry with mortalities, lameness and … Continue reading

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Myriad Genetics (MYGN) Grows on Higher Cancer Test Volumes – Nasdaq

Posted: Published on August 15th, 2017

On Aug 11, we issued an updated research report on Salt Lake City, UT-based molecular diagnostics provider, Myriad Genetics, Inc. MYGN . The company currently carries a Zacks Rank #3 (Hold). For the past three months, Myriad has been trading above the broader industry . The company has rallied 24.7%, compared with the industry's 3.7% gain. Myriad ended fiscal 2017 on a solid note, with its fourth-quarter numbers exceeding the Zacks Consensus Estimate. The company particularly observed strong growth in EndoPredict and GeneSight testing revenues. Also, Myriad witnessed a third consecutive quarter of rise in hereditary cancer volumes. Also, it received provincial reimbursement in Quebec for EndoPredict. Notably, at the European League Against Rheumatism (EULAR) meeting held in June in Spain, Crescendo Bioscience, a wholly-owned subsidiary of Myriad, released new data from a meta-analysis of clinical studies. The data has demonstrated the Vectra DA test's ability to predict a joint damage. The same month, the company announced that its BRACAnalysis CDxcompanion diagnostic test has successfully identified BRCA -mutated patients with HER2- metastatic breast cancer in the OlympiAD trial, who have responded to treatment with olaparib better than standard chemotherapy. Myriad's collaborations with AstraZeneca and BeiGene for development of companion diagnostics … Continue reading

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OU Biology professor awarded grant for corneal research – News at OU

Posted: Published on August 15th, 2017

Sheldon R. Gordon, Ph.D., a professor in the department of Biological Sciences, has been awarded a $15,000 Eye and Vision Research grant by Eversight, a global nonprofit network of eye banks. The grant was awarded in support of his work in the area of corneal research. Dr. Gordon is among nine recipients who received grants from Eversight for research projects that align with the organizations mission to restore sight and prevent blindness. The awards are determined by an independent review panel composed of distinguished scientists, ophthalmologists and health services researchers. This grant provides us with funding to continue our studies and to explore a protein that seems to play a critical role in endothelial physiology and in wound repair, said Dr. Gordon. With the resources we have now, well be able to delve deeper into our studies and determine its exact nature. If these studies turn out the way I hope they will, then we will have positioned ourselves to really be the first to identify this protein and to show what it does specifically. His lab is currently investigating a protein his team discovered on the surface of corneal endothelial cells that appears under stress-like conditions. Previous studies by … Continue reading

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Geoengineering and Synthetic Biology – PLoS Blogs (blog)

Posted: Published on August 15th, 2017

Guest post byDevang Mehta This September, as part of their annual symposium, EUSynBioSwill hold an Open Discussion on the topic, Synthetic Biology and Environmental Engineering,at the National Center for Biotechnology, Madrid, Spain. They will host experts in the field to talk about the science and the more difficult aspects of public acceptance and bioethics surrounding geoengineering and synthetic biology. Geoengineering is a word that means many things to many people. Formally defined as the deliberate intervention in the climate system to counteract man-made global warming, for some scientists it represents a cheap and effective way to protect our planet from the ravages of climate change. To others, it is symptomatic of technological hubris: a grand, doomed plan to control every aspect of our ecosystem. Dig past the rhetoric though and you find a science thats still in its infancy, being developed by scientists around the globe, almost as a last resort in the (now very possible) event that on-going efforts to avert climate catastrophe by reducing global emissions fail. Current research on geoengineering is focused on either removing carbon dioxide from the Earths atmosphere or reducing global warming by reflecting more solar radiation away from the planet. Most proposals to … Continue reading

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Alexion, Sema4 Partner on Rare Disease Diagnostics and Systems Biology – Drug Discovery & Development

Posted: Published on August 15th, 2017

Alexion Pharmaceuticalsand Sema4 announced a strategic partnership to leverage their shared experience in data science and systems biology to accelerate rare disease diagnosis and therapeutic discovery. This new partnership will combine Alexions rare disease SmartPanel analytics with Sema4s proven success in next-generation sequencing and genomic interpretation to further enable novel diagnostic and therapeutic insights into rare diseases. The world-class sequencing capabilities at Sema4 coupled with Alexions SmartPanel analytics will enable a comprehensive evaluation of a patients genome to uncover pathogenic mutations linked to rare diseases, said John Reynders, PhD, Vice President of Data Sciences, Genomics, and Bioinformatics at Alexion. This collaboration will help accelerate an accurate diagnosis for patients with rare genetic diseases and reduce the multi-year process that many families face before receiving a diagnosis. Alexion and Sema4 will also collaborate in searching for and decoding rare disease genomic shields a buffering mechanism that enables patients with a known disease-causing mutation in their genome to resist the manifestation of the disease. The advanced data science and bioinformatics capabilities that Alexion and Sema4 both bring to the table will enable us to decode these unique patients who are resistant to their genetic propensity for disease, said Sema4 CEO, Eric Schadt, … Continue reading

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The American Society for Cell Biology (ASCB) Appoints SPARGO, Inc. as Official Exposition and Advertising Sales and … – Newswise (press release)

Posted: Published on August 15th, 2017

Newswise In August of 2017, SPARGO, Inc. will assume responsibility for the management of exhibit and sponsorship sales for the American Society for Cell Biologys 2017 and 2018 ASCB|EMBO Meetings and 2019 and 2020 ASCB Annual Meetings. Additionally, SPARGO will sell advertising in ASCBs three publications and other digital communications. The Annual Meeting, which has seen steady attendance growth over the past four years, brings together scientists from all over the world to discuss new experimental results and techniques in various domains of basic science and creates the environment for broader discussions on topics ranging from what is cell biology to the future of biomedical research, funding, training, and publishing. The Learning Center at the Annual Meeting will continue to feature technical and scientific exhibits, integrate the poster sessions, and host the popular Tech Talks and microsymposia presentation theaters in which cutting edge content is delivered by the exhibiting companies. The 2017 ASCB|EMBO meeting will be held December 2-6 in Philadelphia, PA. The Northeast/Mid-Atlantic region boasts a large concentration of medical and academic institutions. Holding the conference in this region makes it affordable and convenient for both domestic and international scientists to attend. We are proud to partner with SPARGO, … Continue reading

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Student-friendly, research-savvy new Biology Building opens its doors – Source

Posted: Published on August 15th, 2017

Student-funded The 155,000 square-foot, $70 million building was funded in large part by the University Facility Fee Advisory Board, a group of students who determine the allocation of the student facility fee. Inspired by this funding, the department wanted to make the building people-friendly and individual-friendly, said biology Associate Professor Joe von Fischer. Theres light, theres comfortable seating. Its user-friendly. The biology department is the largest in the College of Natural Sciences, with more than 1,400 undergraduates studying in the biological science or zoology majors More than 60 percent of all CSU undergraduates take a class in the department. No matter what a student is studying, said Associate Professor Rachel Mueller, We made the space of the building to feel creative, to allow students to ask their own questions and foster a sense of wonder. The new building will open up more opportunities for hands-on laboratory work for undergraduate students, both in class and in working with faculty members on their research. Even for those who are not working in a lab, they will be able to see research happening firsthand. The science on display design of the building allows a view into the labs from the hallways through glass … Continue reading

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Nominations open for the PLOS Computational Biology Research Prize! – PLoS Blogs (blog)

Posted: Published on August 15th, 2017

Have you read a 2016PLOS Computational BiologyResearch Article that stood out for you in terms scientific excellence or impact on your field? Maybe you edited or reviewed a manuscript that caught your attention? If so, were delighted to announce that were launching the PLOS Computational Biology Research Prize program, and would like to invite you with the opportunity to become involved! The program celebrates PLOS Computational Biologys best Research Articles published last year (2016), in the following three prize categories: Breakthrough Advance/Innovation Exemplary Methods/Software Public Impact A $2000 prize will be awarded to the authors of the winning Research Article in each category from a pool of public nominations, selected by thePLOS Computational BiologyResearch Prize Committee. Also, to show our appreciation for nominating, each complete nomination of an eligible Research Article published in 2016 will be entered into a random prize drawing to receive a PLOS T-shirt! To tell us which 2016 Research Articles you think are worthy of these awards, please complete ournomination form.Nominations are open to the public untilSeptember 14, 2017 at 11:59 PM ET. If you wish to nominate more than one article, you may submit this form multiple times. For more information on the program, take … Continue reading

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Midland to host community conference for genetic conditions – Baylor College of Medicine News (press release)

Posted: Published on August 15th, 2017

On Saturday, Sept. 16, Baylor College of Medicine will bring a community conference and resource fair to the Midland area to provide an educational seminar and support materials for children with special needs, as well as their parents. Provided jointly by Baylor and Texas Childrens Hospital, in collaboration with SHARE West Texas, the conference will address the role genetic evaluations play in patients with autism spectrum disorders. Dr. Daryl Scott, associate professor of molecular and human genetics at Baylor, will walk parents through the steps of a genetic evaluation and discuss what the findings mean, citing relevant case studies. The emphasis will be placed on common causes of autism, including Fragile X syndrome, chromosomal abnormalities and mutations affecting genes linked to autism. Conference attendees will learn how new genetic tests have made it possible to determine why some children are affected by autism spectrum disorders. When a specific case is identified, it allows physicians to provide accurate counseling and improved medical care for all family members, Scott said. The resource fair will offer current information on care, education and research as they relate to autism spectrum disorders and encourages networking within the community by connecting patients and their families with … Continue reading

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The Search for the Missing AD Heritability Turns Up New Rare Variants – Alzforum

Posted: Published on August 15th, 2017

15 Aug 2017 Genetic forces drive a sizable portion of Alzheimers disease, yet only a fraction of cases thus far are explained by known mutations. A handful of recent papers used genomic sequencing to fish out new variants that, while exceedingly rare, pack a wallop in those who carry them. In the July 24 JAMA Neurology, researchers led by Margaret Pericak-Vance at the University of Miami in Florida reported that mutations in four endolysosomal transport genes boosted risk of early onset AD (EOAD). A few weeks earlier, a large collaboration of French researchers reported rare new TREM2, ABCA7, and SORL1 variants in Neurobiology of Aging, while scientists led by Henne Holstege at VU University Medical Center in Amsterdam characterized the pathogenicity of SORL1 variants and even proposed classifying this endosomal sorting protein as the fourth autosomal-dominant AD gene. A team led by Dominique Campion at University of Rouen, France, dug deep into the well-trodden territory of the three autosomal-dominant genesAPP, PS1, and PS2and uncovered de novo pathogenic variants that cropped up in people with no family history of AD. Last but not least, Anne Rovelet-Lecrux, also at Rouen, linked a duplication in the tau gene to people with an AD … Continue reading

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