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When our favourite TV couples first met – NEWS.com.au

Posted: Published on August 11th, 2017

Meredith confesses her love for Derek asking him to love and choose her over Addison. Courtesy: Grey's Anatomy/abc Jennifer Aniston with David Schwimmer in a scene from Friends. AS the saying goes: every great love story has a beginning. But how did our favourite TV couples, such as Ross and Rachel or Seth and Summer, first meet? Prepare for a trip down memory lane as Decider takes a look back at the first encounters of nine classic TV couples. FYI To clarify, these are the first encounters we watched these characters have on their shows. We know Ross and Rachel knew each other in high school, but were focusing on their initial interaction on the series. ROSS AND RACHEL (FRIENDS) Whats the situation? So no one told Ross and Rachel that life was going to be this wayyyyy. As were introduced to the Central Perk 6, Ross is getting divorced and Rachel just pulled a Runaway Bride on her wedding day. While the two knew each other in high school, this scene is the future couples first encounter on the series. First encounter: Monica: You remember my brother Ross? Rachel: Sure. Hi ... ah! *An awkward Ross opens an umbrella … Continue reading →

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Grey's Anatomy: Will Jackson and Maggie really get together? – EW.com (blog)

Posted: Published on August 11th, 2017

A new romance might be in the air when Greys Anatomy returns. After the season 13 finale hinted at a potential romance for Jackson (Jesse Williams) and Maggie (Kelly McCreary), fans of the ABC medical drama have spent the hiatus wondering if Japril is out and Jaggie Mackson? is in. April (Sarah Drew) pointed out the potential in the finale, telling Maggie she believes her ex-husband and the cardio doc who grew close when Jackson treated Maggies dying mother have feelings for one another. What April said to her literally had not crossed her mind, so I think its a question shes grappling with whether theres any truth to that, and if there is, what to do with it, and if theres not, how to manage if theres truth for Jackson in that, McCreary tells EW. Shes on fertile ground trying basically to find out whether April was onto something shes unaware of. When Greys Anatomy returns this fall, the series will pick up right where the finale left off following the hospital explosion, which means Aprils words will still be ringing in Maggies ears. So, will Maggie take a shot with Jackson? The truth is that still remains to … Continue reading →

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Everything We Know About 'Grey's Anatomy' Season 14 (PHOTOS) – Wetpaint

Posted: Published on August 11th, 2017

Whats the prognosis for Greys Anatomy Season 14? Drama, of course. But its also going to be a lighter, sexier season, the stars say with new faces joining the show and familiar faces coming back for more action. The season is still weeks away, though, so our prescription for you is to click through the slides of this gallery. Just be warned: Side effects include spoilers. Greys Anatomy Season 14 premieres on Thursday, September 28, at 8 p.m. ET on ABC. Tip: Use keyboard arrows to navigate Season 14 premieres on September 28. Thats Thursday, September 28, at 8 p.m. ET on ABC, to be exact. In fact, the last time a season of Greys premiered any time other than the week of September 21-28 was Season 1. Were getting a two-hour premiere Twice the episode for twice the fun! Shonda knows how to treat us. The first episode is titled Break Down the House It was written by new showrunner Krista Vernoff, whos returning to the show for the first time since Season 7, and directed by exec producer/star Debbie Allen. Season 14 pick up right where Season 13 left off The docs will still be reeling from the … Continue reading →

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13 Grey's Anatomy characters we definitely don't miss – Hidden Remote

Posted: Published on August 11th, 2017

Use your (arrows) to browse Photo Credit: Greys Anatomy/ABC Image Acquired from ABC Studios Press All TV shows have those characters that fans hate with a passion, including Greys Anatomy. Or there are characters that just dont seem to be interesting or vibrant enough to gain a lot of love. These characters leave with either little fanfare or with fans cheering for their demise. Its a shame that actors are no longer working on the show, but the characters certainly do not end up missed. On the odd occasion, an unlikable character does get an emotional and well-created exit. We can be left wondering if there could have been something more, but a rewatch of an episode reminds us of why we hated that character with a passion. With the news that a certain character is not returning to the show, I cant help but think about how much I wont miss her. A lot of fans feel the same, and its brought up the question of other characters we dont really miss from the show. There are a lot of reasons why we dont miss a character inGreys. Sometimes its because they were just hateful characters but others are … Continue reading →

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Genetic risk factors for autism may affect family size – Spectrum

Posted: Published on August 11th, 2017

Age effect: Men and women at genetic risk for autism tend to become parents relatively late in life. Ghislain & Marie David de Lossy / iStock People who carry risk factors for autism but do not have the condition tend to have fewer children and have them later in life than do people at lower risk, according to a new study1. The study of more than 90,000 people focuses on common genetic variants, which occur in at least 1 percent of the population. Certain combinations of these variants are thought to increase the risk of autism. The study suggests that variants linked to autism also affect whether and when people have children. For instance, having variants that lead to social difficulties might make it hard to find a mate. It is clear that the brain is an important reproductive organ, says lead researcher Kri Stefnsson, founder of deCODE Genetics in Iceland. The findings,published 13 June in Nature Communications, may help to explain why autism is more prevalent among children who have older parents. Previous studies have suggested that sperm from older fathers is more prone to spontaneous mutations that boost autism risk. The new work supports another explanation: that people … Continue reading →

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Crohn’s | Colitis | IBD | Crohns & Colitis Foundation

Posted: Published on August 10th, 2017

GET INVOLVED Summer is a great time to get involved with the Crohn's & Colitis Foundation! Join the Team Challenge Family -- 10 years of racing for curesWhen you join the Team Challenge family,you're supported by coaches, mentors, and friends who understand the impact of IBD. Join us this year at a 5k, 10k, half marathon, marathon, triathlon, IRONMAN, cycle event -- or, turn anything else into a fundraiser when you Race in Orange. Learn more. 2017 spin4 crohn's & colitis cures lineup just announced!It's not too early to join the movement at one ofour 2017 spin4 crohn's & colitis cures fall events. The time is now -- grab some friends, reserve your bike, and join this fun indoor cycling relay! I want to #partyonabike! Click on the arrow to select your state to find information on your local Chapter. Enter your email address to receive the national newsletter and enter your zip code to receive your local chapter newsletter. Click on the arrow to view various topics applicable to Crohn's disease and ulcerative colitis.More in Resources Read more: Crohn's | Colitis | IBD | Crohns & Colitis Foundation … Continue reading →

Posted in Ulcerative Colitis | Comments Off on Crohn’s | Colitis | IBD | Crohns & Colitis Foundation

InDex Pharmaceuticals Receives Orphan-drug Designation for … – Markets Insider

Posted: Published on August 10th, 2017

STOCKHOLM, August 9, 2017 /PRNewswire/ -- InDex Pharmaceuticals Holding AB (publ) today announced that the US Food and Drug Administration (FDA) has granted orphan-drug designation for the drug candidate cobitolimod for treatment of ulcerative colitis in pediatric patients. "We are pleased that the FDA has granted orphan-drug designation for cobitolimod for treatment of ulcerative colitis in children, which may provide seven years of market exclusivity in this indication on the US market," said Peter Zerhouni, CEO of InDex Pharmaceuticals. "The decision shows the medical need for new therapeutic options for this patient population and gives InDex additional opportunities to interact with the FDA." Cobitolimod in brief Cobitolimod is a new type of drug that can help patients with moderate to severe ulcerative colitis back to a normal life. It is a so-called Toll-like receptor 9 (TLR9) agonist, that can provide an anti-inflammatory effect locally in the large intestine, which may induce mucosal healing and relief of the clinical symptoms in ulcerative colitis. Cobitolimod has achieved clinical proof-of-concept in moderate to severe active ulcerative colitis, with a very favorable safety profile. Data from four placebo-controlled clinical trials indicate that cobitolimod has statistically significant effects on those endpoints that are most relevant … Continue reading →

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If You Live in a City, Science Says You’re More at Risk of These Incurable Diseases – Reader’s Digest

Posted: Published on August 10th, 2017

Inflammatory bowel disease refers to a miserable set of symptoms that dont usually get discussed in polite company. IBD is one of the common sources of stomach distressand it can be responsible for abdominal cramping, diarrhea, and bloody stool, fatigue, and weight loss. The most common sources of IBD are Crohns Disease and ulcerative colitis, and cases are on the rise, according to the Centers for Disease Control and Prevention. Now a recent study suggests that rural livingespecially during the first five years of a childs lifeprovides significant protection from these conditions. Lead study author Eric I. Benchimol MD, PhD, and colleagues relied on health data collected during surveys of virtually all residents of the Canadian provinces of Alberta, Manitoba, Nova Scotia, and Ontario. In 2011, the provinces had a combined population of more than 19 million peopleand 45,567 of them had either Crohns Disease or ulcerative colitis. Taras Mikhailyuk/shutterstock Once Dr. Benchimol divided the groups into rural versus urban, he found that the incidence of IBD for country folk was 30.72 per 100,000; in cities, the rate was 33.16 per 100,000. In addition, rural patients were diagnosed at an older age than urban patients. The study, which was conducted … Continue reading →

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RNA-targeting CRISPR could yield treatments for Huntington’s, ALS – FierceBiotech

Posted: Published on August 10th, 2017

Researchers from the University of California, San Diego have used a new version of the gene editing technology CRISPR to fix problems in RNA, rather than to change DNA, a promising step for a group of diseases, including Huntingtons and amyotrophic lateral sclerosis, that have no cure. CRISPR uses the Cas9 enzyme and a "guide" RNA to snip out mutations in DNA, but until recently, it has not been used to target RNA. After using the method to track RNA in live cells last year, the UC San Diego team is now correcting mistakes in RNA that lead to microsatellite repeat expansion diseases. In these disorders, too many repeats in RNA sequences causes RNA to clump together in cells, preventing them from producing essential proteins. The team tested their RNA-targeted Cas9 (RCas9) system on laboratory modelsand found that the method cleared 95% or more of the RNA clumpscalled focirelated to myotonic dystrophy, one type of ALS and Huntington's disease. It also eliminated 95% of errant repeat RNAs in cells taken from patients with myotonic dystrophy. The findings are published in Cell. "We are really excited about this work because we not only defined a new potential therapeutic mechanism for CRISPR-Cas9, … Continue reading →

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Lives hang in the balance while the FDA bureaucracy churns – Washington Examiner

Posted: Published on August 10th, 2017

The McLinn family of Indianapolis is still fighting for their seven-year-old son, Jordan, who was diagnosed at the age of 3 with Duchenne muscular dystrophy. This is an aggressive disease that results in muscle weakness and loss first attacking the extremities, eventually moving to the heart and other internal organs. There is no known cure, yet, but there are treatments that can help manage symptoms and slow progression of the disease. For people like Jordan McLinn, failure or needless delay of the Food and Drug Administration to grant a compassionate use request (also known as expanded access) can mean the difference between walking or being wheelchair-bound. Currently, the FDA has the authority to not approve access to potentially life-saving medicine based on the agency's criteria meaning, the FDA must determine that "the potential patient benefit justifies the potential risks of the treatment use and those potential risks are not unreasonable in the context of the disease or condition to be treated." In a country that prides itself on upholding individual liberties, it's contradictory that the government reserves the right to grant or deny individuals who are fighting for their lives access to potentially life-saving medicine simply based on the agency's … Continue reading →

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