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Grant to compare large-scale genomic sequencing, standard clinical tests for childhood cancer patients – Baylor College of Medicine News (press…

Posted: Published on August 9th, 2017

Baylor College of Medicine is one of six U.S. institutions to receive a grant through the National Human Genome Research Institutes Clinical Sequencing Evidence-Generating Research Consortium, or CSER2. The four-year grant, including $2.8 million for fiscal year 2017, co-funded by the National Cancer Institute, will support Baylors new KidsCanSeq program that will compare the results of large-scale genomic testing, such as whole exome sequencing, to targeted clinical tests in childhood cancer patients at five sites across the state that serve a highly diverse patient population, including Texas Childrens Cancer Center. In addition to Texas Childrens Cancer Center, pediatric patients will be enrolled in KidsCanSeq at the Vannie E. Cook Childrens Cancer Clinic in McAllen, the Childrens Hospital of San Antonio, the University of Texas Health Science Center at San Antonio, and Cook Childrens Health Care System in Fort Worth. KidsCanSeq follows the Baylor Advancing Sequencing in Childhood Cancer Care(BASIC3) study at Baylor and Texas Childrens Cancer Center, which developed the initial protocols for performing clinical genomic testing of pediatric cancer patients, reporting results and communicating those results to families and oncologists. BASIC3 was part of the NHGRI Clinical Sequencing Exploratory Research program, a precursor to CSER2. Through BASIC3 we explored … Continue reading

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Here’s where experts say we should draw the line on gene-editing experiments on human embryos – Los Angeles Times

Posted: Published on August 9th, 2017

A day after a blockbuster report that researchers had edited harmful genetic mutations out of human embryos in an Oregon lab, an international group of genetics experts urged scientists against taking the next step. A panel of the American Society of Human Genetics, joined by representatives from 10 organizations scattered across the globe, recommended against genome editing that culminates in human pregnancy. Their views were published Thursday in the American Journal of Human Genetics. In the United States, the Food and Drug Administration forbids any medical use of gene editing that would affect future generations, and the agency strictly regulates experimental use of the technology in labs. But around the world, scientists sometimes circumvent restrictions like these by conducting clinical work in countries that have no such strictures. People who want to gain access to these techniques can find people willing to perform them in venues where they are able to do so, said Jeffrey Kahn, director of the Berman Center for Bioethics at Johns Hopkins University. That underscores the importance of international discussion of what norms we will follow. Indeed, some of the groups signing on to the new consensus statement acknowledged that they inhabit parts of the world … Continue reading

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Genetics expert discusses creating ground rules for human germline … – Medical Xpress

Posted: Published on August 9th, 2017

A Stanford professor of genetics discusses the thinking behind a formal policy statement endorsing the idea that researchers continue editing genes in human germ cells. A team of genetics experts has issued a policy statement recommending that research on editing human genes in eggs, sperm and early embryos continue, provided the work does not result in a human pregnancy. Kelly Ormond, MS, professor of genetics at the Stanford School of Medicine, is one of three lead authors of the statement, which provides a framework for regulating the editing of human germ cells. Germ cells, a tiny subset of all the cells in the body, give rise to eggs and sperm. Edits to the genes of germ cells are passed on to offspring. The statement, published today in the American Journal of Human Genetics, was jointly prepared by the American Society for Human Genetics and four other human genetics organizations, including the National Society of Genetic Counselors, and endorsed by another six, including societies in the United Kingdom, Canada, Australia, Africa and Asia. Germline gene editing raises a host of technical and ethical questions that, for now, remain largely unanswered. The ASHG policy statement proposes that federal funding for germline genome … Continue reading

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Jennifer Cochran appointed chair of bioengineering – Stanford Medical Center Report

Posted: Published on August 9th, 2017

Jennifer Cochran, PhD, has been appointed chair of Stanfords Department of Bioengineering, which is jointly operated by the School of Medicine and School of Engineering. Her five-year term begins Sept. 1. This department has an amazing energy due in no small part to its faculty, students and staff, said Cochran, associate professor of bioengineering. These individuals nearly 500 of them, in all have an unwavering commitment to research, learning and service, and they exude a spirit of collegiality and collaboration that permeates our department and the broader Stanford community. Cochrans research is interdisciplinary, integrating chemistry, engineering and biophysics. Her laboratory focuses on protein-based drug discovery for applications including oncology and regenerative medicine, and the development of new technology for high-throughput protein analysis and engineering. In addition to being a superb scholar and educator and a proponent of deeper connections with Silicon Valleys burgeoning biotechnology activities, Jennifer is an enthusiastic, dynamic individual who will bring exciting leadership to the department and be a key contributor to the schools of Engineering and Medicine, Lloyd Minor, MD, dean of the School of Medicine, and Jennifer Widom, PhD, dean of the School of Engineering, said in a joint statement. Cochran will succeed Norbert Pelc, … Continue reading

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Zachary Ball to Lead Institute of Biosciences and Bioengineering – Texas Medical Center (press release)

Posted: Published on August 9th, 2017

Rice University chemist Zachary Ball has been named director of Rices Institute of Biosciences and Bioengineering (IBB). The institute promotes interdisciplinary research and education encompassing physics, chemistry, biology and engineering.Ball succeeds Jane Grande-Allen, who will continue to serve as the Isabel C. Cameron Professor and chair of the Department of Bioengineering. Zach is our first chemist in the role of IBB director and I am very excited about how he will expand the scope of our collaborative research, said Yousif Shamoo, Rices vice provost for research, who announced the appointment. Ball sees his role with IBB as an opportunity to soften boundaries between departments at Rice and to help faculty connect with outside researchers in the Texas Medical Center. There is this inherent tension at a university, Ball said. We still need a traditional department structure, but theres also a need to empower faculty in ways that are bigger and broader than traditional departments can provide. Thats a big reason why IBB is and remains a hugely important part of the Rice research ensemble. Its uniquely situated to encourage faculty collaboration. Zach brings an objective clarity on integration, said Paul Cherukuri, IBBs executive director. He has a great analytical understanding … Continue reading

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Virtual competitors vie for a different kind of athletic title | Stanford … – Stanford University News

Posted: Published on August 9th, 2017

Modeling the walk Kidziski works in the lab of Scott Delp, a professor of bioengineering and of mechanical engineering who has spent decades studying the mechanics of the human body. As part of that work, Delp and his collaborators have collected data on the movements and muscle activity of hundreds of individuals as they walk and run. With data like that, Delp, Kidziski and their team can build accurate models of how individual muscles and limbs move in response to signals from the brain. But what they could not do was predict how people relearn to walk after surgery because, as it turns out, no one is quite sure how the brain controls complex processes like walking, let alone walking through the obstacle course of daily life or relearning how to walk after surgery. Whereas weve gotten quite good at building computational models of muscles and joints and bones and how the whole system is connected how the human machine is built an open challenge is how your brain orchestrates and controls this complex dynamic system, Delp said. Machine learning, a variety of artificial intelligence, has reached a point where it could be a useful tool for modeling of the … Continue reading

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2017-2022 Global Bioreactors and Fermenters Market Analysis : Applikon Biotechnology , Bioengineering AG , Infors … – First Newshawk

Posted: Published on August 9th, 2017

Worldwide Bioreactors and Fermenters Market 2017 presents a widespread and fundamental study of Bioreactors and Fermenters industry along with the analysis of subjective aspects which will provide key business insights to the readers. Global Bioreactors and Fermenters Market 2017 research report offers the analytical view of the industry by studying different factors like Bioreactors and Fermenters market growth, consumption volume, market trends and Bioreactors and Fermenters industry cost structures during the forecast period from 2017 to 2022. Bioreactors and Fermenters market studies the competitive landscape view of the industry. The Bioreactors and Fermenters report also includes development plans and policies along with manufacturing processes. The major regions involved in Bioreactors and Fermenters Market are (United States, EU, China, and Japan). For Sample Copy Of The Report Click Here: https://market.biz/report/global-bioreactors-and-fermenters-market-2017/94290/#inquiry Leading Manufacturers Analysis in Global Bioreactors and Fermenters Market 2017: 1 Sartorius AG ?BBI?2 Thermo Fisher3 Merck KGaA4 GE Healthcare5 Danaher (Pall)6 Eppendorf AG7 Praj Hipurity Systems8 Pierre Guerin (DCI-Biolafitte)9 ZETA10 Applikon Biotechnology11 Bioengineering AG12 Infors HT13 Solaris14 Other Bioreactors and Fermenters Market: Type Segment Analysis Single-use BioreactorsMultiple-use Bioreactors Bioreactors and Fermenters Market: Applications Segment Analysis Biopharmaceutical CompaniesCROsAcademic and Research InstitutesOthers The Bioreactors and Fermenters report does the thorough study of … Continue reading

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Radical New Drug-Testing Tech Could Dramatically Cut Animal Testing – The Jewish Voice

Posted: Published on August 9th, 2017

Israeli human-on-a-chip platform has the unique ability to predict risk of toxicity in pharma and cosmetic product candidates without animal testing After spending an average of $2.5 billion to develop a single new drug, sometimes pharma companies have to pull it from the market due to a bad outcome that was not detected in clinical studies. Thats what happened in 2000, when a promising Type 2 diabetes drug called troglitazone led to idiosyncratic (unexplained) liver damage in one of every 60,000 users. The troglitazone mystery wasnt solved until March 2016, when a novel liver-on-a-chip platform developed by Hebrew University of Jerusalem Prof. Yaakov Nahmias revealed what no animal or human tests could: even low concentrations of this drug caused liver stress before any damage could be seen. It was the first time an organ-on-chip device could predict information to help pharmaceutical companies define risk for idiosyncratic toxicity, Nahmias tells ISRAEL21c. Shortly before that study, Nahmias liver-on-a-chip had revealed a new mechanism for acetaminophen (Tylenol) poisoning. Given that about 16 percent of all FDA-approved drugs eventually show unexpected toxicity, Nahmias recognized the potential of his smart human-on-a-chip platform. He licensed the technology from the university and spun off Tissue Dynamics to … Continue reading

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Missoula educators on ice: A trip to the Arctic for chemistry professor, teacher – The Missoulian

Posted: Published on August 9th, 2017

When the Canadian icebreaker CCGS Louis S. St-Laurent pushes off from the Nunavut coast in September, it will have two Missoula educators on board. University of Montana professor Michael DeGrandpre and Big Sky High School chemistry teacher Dave Jones will be working in tandem on the complex issues of climate change and ocean acidification. Jones was awarded a research fellowship from PolarTREC, a teacher research and exploration program that, according to its website, is designed to invigorate polar science education and understanding by bringing educators and polar researchers together. PolarTREC links high school teachers to active researchers and, as Jones notes, brings real world research back to the classroom, and shows them why pH and solution chemistry matters. DeGrandpres work revolves around ocean acidification. When carbon dioxide in the atmosphere is absorbed by the ocean, it makes seawater more acidic, which can dissolve the shells of oysters, crabs and other creatures and can kill coral reefs. Working on the Louis S. St. Laurent is important to gather data points about the rapidly changing ocean chemistry. Scientists are really motivated, and its a crucial place to be, DeGrandpre said. Changes in the Arctic can drastically shift the weather dynamics in the … Continue reading

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Vikings WR Jarius Wright working to develop chemistry with QB Sam Bradford – TwinCities.com-Pioneer Press

Posted: Published on August 9th, 2017

MANKATO Jarius Wrights two best NFL seasons came with Teddy Bridgewater throwing him the ball. After Sam Bradford joined the team last year, the Vikings wide receiver barely played. That wasnt necessarily because of the change in quarterbacks. Stefon Diggs played more in the slot last season, taking time from Wright. And the emergence of Adam Thielen as a high-usage receiver played a role. Wright and Bradford, though, seem to be making up for lost time. Bradford hit Wright on some nice balls in training camp at Minnesota State Mankato, including a long one down the right side and one down the left side in Saturdays night practice. I think me and Sam are starting to become, I dont want to say one, but were starting to think alike, Wright said this week. Were starting to be on the same page. Were starting to talk about more routes together and things like that. With Bridgewater as the starting quarterback, Wright had seasons of catching 42 passes in 2014 and 34 in 2015. He likes feeding me on third down, Wright, a six-year veteran, said Friday. Thats my guy. Bridgewater, though, was lost for the year with a knee injury suffered … Continue reading

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