Credit: CC0 Public Domain A new study in rats shows that changes in the brain after spinal cord injury are necessary to restore at least some function to lower limbs. The work was published recently in the journal eLife. "After injury, the spinal cord cannot go back to its original state before the injury. If an animal receives rehabilitation therapy, we now know that the spinal cord will go to a new state that supports functional recovery. Under these conditions, the brain must also change and re-learn to communicate with the new state of the spinal cord," said Karen Moxon, professor of biomedical engineering at UC Davis and senior author on the paper. Moxon and colleagues used a combination of physical therapy (cycling and semi-load bearing treadmill training) and treatment with the drug serotonin, which stimulates nerve cells, in rats with a severed spinal cord that could not voluntarily move their hind legs. The rats partially recovered their ability to move their hind limbs while on the treadmill and were even able to take consecutive, independent steps, the researchers found. This occurred without healing of the break in the spinal cord. Instead, the nerve cells above the break appear to … Continue reading
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