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Working around spinal injuries: Rehabilitation, drug treatment lets rats recover some involuntary movement – Medical Xpress

Posted: Published on July 31st, 2017

Credit: CC0 Public Domain A new study in rats shows that changes in the brain after spinal cord injury are necessary to restore at least some function to lower limbs. The work was published recently in the journal eLife. "After injury, the spinal cord cannot go back to its original state before the injury. If an animal receives rehabilitation therapy, we now know that the spinal cord will go to a new state that supports functional recovery. Under these conditions, the brain must also change and re-learn to communicate with the new state of the spinal cord," said Karen Moxon, professor of biomedical engineering at UC Davis and senior author on the paper. Moxon and colleagues used a combination of physical therapy (cycling and semi-load bearing treadmill training) and treatment with the drug serotonin, which stimulates nerve cells, in rats with a severed spinal cord that could not voluntarily move their hind legs. The rats partially recovered their ability to move their hind limbs while on the treadmill and were even able to take consecutive, independent steps, the researchers found. This occurred without healing of the break in the spinal cord. Instead, the nerve cells above the break appear to … Continue reading

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ReNetX Bio Launched to Advance Innovative Neuro-Regenerative … – GlobeNewswire (press release)

Posted: Published on July 31st, 2017

Company Appoints Erika R. Smith as CEO; Previously Director at Yale Innovation Fund Initiates Series A Financing Round to Fund Clinical Trial in Chronic Spinal Cord Injury NEW HAVEN, Conn., July 24, 2017 (GLOBE NEWSWIRE) -- ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, today announced its launch as a new company with the appointment of Erika Smith as Chief Executive Officer. The company also announced the initiation of a Series A financing round to fund its first clinical trial of its lead therapeutic candidate, Nogo Trap, in patients with chronic spinal cord injury. ReNetX licensed the rights of the innovative neuro-restorative Nogo Receptor platform technology discovered by Stephen Strittmatter, M.D., Ph.D., at Yale University and founder and scientific advisor to ReNetX. The central nervous system contains major extracellular factors that limit regrowth of neurons. The company has developed a decoy receptor, called Nogo Trap, that binds the growth inhibitors allowing the body to grow nerve fibers naturally and directly targeting restoration across all facets of growth: axonal regeneration (long distance), axonal sprouting (medium distance) and synaptic plasticity. ReNetX, formerly known as Axerion Therapeutics, currently receives development support for the Nogo Trap chronic … Continue reading

Posted in Spinal Cord Injury Treatment | Comments Off on ReNetX Bio Launched to Advance Innovative Neuro-Regenerative … – GlobeNewswire (press release)

Trump tells cops, ‘Don’t be too nice’ when placing suspects in custody – Cecil Whig

Posted: Published on July 31st, 2017

BALTIMORE President Donald Trump on Friday encouraged police officers to be rough with suspects they are placing in custody, an apparent joke Baltimore officials criticized as inappropriate in light of police reform efforts here and elsewhere. Trump was speaking to officers in Suffolk County, New York, to highlight his administrations efforts to crack down on illegal immigration and the street gang known as MS-13. But he took a moment to criticize police officers who he thinks treat suspects too gingerly. When you see these thugs being thrown into the back of a paddy wagon you just see them thrown in, rough I said, Please dont be too nice, Trump said, eliciting laughter from officers. Like when you guys put somebody in the car and youre protecting their head, you know, the way you put their hand over? Like, dont hit their head and theyve just killed somebody dont hit their head. I said, You can take the hand away, okay? A spokesman for Mayor Catherine Pugh characterized Trumps comments as insensitive. City officials are struggling to stunt a spike in homicides that began soon after Freddie Gray died of a spinal cord injury he suffered after being placed without a … Continue reading

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UCI researchers use stem cells as cancer-seeking missiles – 89.3 KPCC

Posted: Published on July 31st, 2017

A close-up of cell mutations that cause cancer. Steve Gschmeissner/Science Source Chemotherapy is brutal a medicinal atomic bomb that destroys large swaths of cells, both cancerous and normal. And as a result, patients are often left physically devastated. In a new study published in Science Translational Medicine, scientists at UC Irvine say they've come up with a way to use stem cells to help ameliorate those side effects. Think of it as a surgical strike with cancer-seeking missiles. Professor Weian Zhao and his colleagues from UC Irvine modified stem cells so that they'd be attracted to enzymes released by breast cancer tumors. So, when injected into the body, the stem cells seek out the cells and bond with them. The enzymes the scientists identified cause tissue to clump up into bundles of collagen and protein to create stiff tumors. The tumors become lumps that a patient can sometimes feel, and they act as a protective home for the cancerous cells. The stem cells release an enzyme of their own, in turn, activating a type of chemotherapy that's been injected into the patient, which is inert until in comes in contact with the enzyme. The idea being that the chemotherapy only … Continue reading

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Stem cell brain implants could ‘slow ageing and extend life’, study … – The Guardian

Posted: Published on July 31st, 2017

Scientists have slowed down the ageing process by implanting stem cells into the brains of animals, raising hopes for new strategies to combat age-related diseases and extend the human lifespan. Implants of stem cells that make fresh neurons in the brain were found to put the brakes on ageing in older mice, keeping them more physically and mentally fit for months, and extending their lives by 10-15% compared to untreated animals. The work, described as a tour de force and a breakthrough by one leading expert, suggests that ageing across the body is controlled by stem cells that are found in the hypothalamus region of the brain in youth, but which steadily die off until they are almost completely absent in middle age. Researchers at Albert Einstein College of Medicine in New York hope to launch clinical trials of the procedure soon, but must first produce supplies of human neural stem cells in the lab which can be implanted into volunteers. Of course humans are more complex, said Dongsheng Cai, who led the research. However, if the mechanism is fundamental, you might expect to see effects when an intervention is based on it. Previous experiments had already hinted that the … Continue reading

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Revised draft norms for stem cell research marks many restrictive areas – pharmabiz.com

Posted: Published on July 31st, 2017

The revised draft National Guidelines for Stem Cell Research, 2017, released recently by the Indian Council of Medical Research (ICMR) and the Department of Biotechnology (DBT), has earmarked several restrictive areas of research in stem cell such as creation of human pre-implantation embryos by IVF, ICSI, SCNT or any other method with the specific aim of deriving ESC lines for any purpose. The guidelines state that such research needs close supervision and strict adherence to the guidelines. The investigator needs to provide reasoning taking into consideration that the proposed research cannot be carried out with existing ESC lines, or those that can be derived from spare embryos; minimum number of embryos/blastocysts required for such research must be clearly defined; research teams involved should have appropriate expertise and requisite training in derivation, characterization and culture of ESCs. As per the revised guidelines, clinical trials using any type of stem cells (progenitor or differentiated) after major manipulation shall require prior approval of the CDSCO after obtaining approval from IC-SCR and IEC. Clinical trials sponsored by multinationals, employing cell products developed outside India, will also need prior approval from CDSCO following clearance from both IC-SCR and IEC. All international collaborations require approvals from … Continue reading

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DNA Definition: Shape, Replication, and Mutation

Posted: Published on July 31st, 2017

Definition: DNA (deoxyribonucleic acid) is a type of macromolecule known as a nucleic acid. It is shaped like a twisted double helix and is composed of long strands of alternating sugars and phosphate groups, along with nitrogenous bases (adenine, thymine, guanine and cytosine). DNA is organized into structures called chromosomes and housed within the nucleus of our cells. DNA is also found in cell mitochondria. DNA contains the genetic information necessary for the production of cell components, organelles, and for the reproduction of life. Protein production is a vital cell process that is dependent upon DNA. Information contained within the genetic code is passed from DNA to RNA to the resulting proteins during protein synthesis. DNA is composed of a sugar-phosphate backbone and nitrogenous bases. In double-stranded DNA, the nitrogenous bases pair up. Adenine pairs with thymine (A-T) and guanine pairs with cytosine (G-C). The shape of DNA resembles that of a spiral staircase. In this double helical shape, the sides of the staircase are formed by strands of deoxyribose sugar and phosphate molecules. The stair steps are formed by the nitrogenous bases. The twisted double helix shape of DNA helps to make this biological molecule more compact. DNA is … Continue reading

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DNA and Genes – 2017 News and Scientific Articles on Live Science

Posted: Published on July 31st, 2017

Genes are the blueprints of life. Genes control everything from hair color to blood sugar by telling cells which proteins to make, how much, when, and where. Genes exist in most cells. Inside a cell is a long strand of the chemical DNA (deoxyribonucleic acid). A DNA sequence is a specific lineup of chemical base pairs along its strand. The part of DNA that determines what protein to produce and when, is called a gene. First established in 1985 by Sir Alec Jeffreys, DNA testing has become an increasingly popular method of identification and research. The applications of DNA testing, or DNA fingerprinting within forensic science is often what most people think of when they hear the phrase. Popularized by television and cinema, using DNA to match blood, hair or saliva to criminals is one purpose of testing DNA. It is also frequently used for other benefits, like wildlife studies, paternity testing, body identification, and in studies pertaining to human dispersion.While most aspects of DNA are identical in samples from all human beings, concentrating on identifying patterns called microsatellites reveals qualities specific and unique to the individual. During the early stages of this science, a DNA test was performed using … Continue reading

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Sunscreen made from DNA would last forever – Popular Science

Posted: Published on July 31st, 2017

A DNA-based sunscreen that not only stops harmful ultraviolet (UV) light, but also becomes more protective the longer you expose it to UV rays? Thats the dazzling premise behind a recent study published in the journal Science Reports. While sunscreen isnt the only form of sun protection (theres always protective clothing and floppy hats), the reality is that most of us just skip it. A 2015 study in Journal of the American Academy of Dermatology found that only 14.3 percent of men and 29.9 percent of women routinely use sunscreen when they are in outside for more than an hour. This wouldnt be a problem, except, Ultraviolet light is a carcinogen, Guy German a biomedical researcher at Binghamton University in New York and an author on the study, tells PopSci. We know it can give you a tan, but it can also cause cancer as well. While dermatoepidemiologists (scientists who study diseases of the skin) suspect that sunlight causes cancer because it damages DNA in our cells, German and his colleagues were looking at DNA in an entirely different way. They wondered what would happen if they exposed DNA film, essentially a thin sheet of the stuff, to the same … Continue reading

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She thought she was Irish until a DNA test opened a 100-year-old mystery – Chicago Tribune

Posted: Published on July 31st, 2017

Five years ago, Alice Collins Plebuch made a decision that would alter her future or really, her past. She sent away for a "just-for-fun DNA test." When the tube arrived, she spit and spit until she filled it up to the line, and then sent it off in the mail. She wanted to know what she was made of. Plebuch, now 69, already had a rough idea of what she would find. Her parents, both deceased, were Irish-American Catholics who raised her and her six siblings with church Sundays and ethnic pride. But Plebuch, who had a long-standing interest in science and DNA, wanted to know more about her dad's side of the family. The son of Irish immigrants, Jim Collins had been raised in an orphanage from a young age, and his extended family tree was murky. After a few weeks during which her saliva was analyzed, she got an email in the summer of 2012 with a link to her results. The report was confounding. About half of Plebuch's DNA results presented the mixed British Isles bloodline she expected. The other half picked up an unexpected combination of European Jewish, Middle Eastern and Eastern European. Surely someone in … Continue reading

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