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DNA not sent for testing; judge orders release of two capital murder suspects – WFAA

Posted: Published on July 6th, 2017

Judge releases capital murder suspects Tanya Eiserer, WFAA 3:48 PM. CDT July 05, 2017 A Dallas County district judge has ordered the release of two capital murder suspects after prosecutors failed for more than a year to send the DNA of one of the defendants to the lab to be tested. On Monday the judge ordered that Leonte Stone, 24, and Konkun Tarpeh, 25, be released on electronic monitoring and house arrest. The only thing keeping the two men in jail currently are holds from other counties. Tarpeh is being held on a Tarrant County violation on a protective order charge from Tarrant County. Stone is being held from Hunt County for evading arrest and child endangerment charges. By state law, prosecutors have 90 days to announce that they're ready for trial from the day that a person is arrested. That's to keep indigent defendants from just being held in jail in perpetuity. In this case, prosecutors had failed to send Stones DNA to the lab to be tested against evidence collected in the case. District Judge Brandon Birmingham ordered their release on a personal recognizance bond. The DNA testing also cant be done quickly because of a recent issue … Continue reading

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Oxford BioMedica Wins Big Contract for Novartis Cell Therapy – New York Times

Posted: Published on July 6th, 2017

LONDON Novartis has signed a major contract with Oxford BioMedica that could earn the British company more than $100 million (77.32 million pounds) over three years for supplying the Swiss drugmaker with material for its novel cell therapy CTL019. The deal, announced by Oxford BioMedica on Thursday, could help put the veteran biotech firm on a path to sustainable profitability. The contract is for the supply of lentiviral vectors used to generate CTL019, a new kind of treatment for hard-to-treat leukaemia that is expected to reach the market this year. A U.S. advisory panel will discuss the case for approving CTL019 at a meeting on July 12 and Novartis has already designated the treatment as a potential blockbuster. Oxford BioMedica will received $10 million from Novartis upfront, as well as payments for various performance incentives and bioprocessing and development services. It will also get a royalty on future sales of CTL-019. Jefferies analysts said this could earn Oxford BioMedica between 65 million and 75 million pounds ($84-97 million) a year, assuming CTL019 peak sales of at least $1 billion. The agreement also covers the supply of vectors for other undisclosed Chimeric Antigen Receptor T cell (CART) products. Excerpt from: Oxford … Continue reading

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Global Cell Therapy Report 2017 – Technologies, Markets and … – PR Newswire (press release)

Posted: Published on July 6th, 2017

This report describes and evaluates cell therapy technologies and methods, which have already started to play an important role in the practice of medicine. Hematopoietic stem cell transplantation is replacing the old fashioned bone marrow transplants. Role of cells in drug discovery is also described. Cell therapy is bound to become a part of medical practice. Stem cells are discussed in detail in one chapter. Some light is thrown on the current controversy of embryonic sources of stem cells and comparison with adult sources. Other sources of stem cells such as the placenta, cord blood and fat removed by liposuction are also discussed. Stem cells can also be genetically modified prior to transplantation. Cell therapy technologies overlap with those of gene therapy, cancer vaccines, drug delivery, tissue engineering and regenerative medicine. Pharmaceutical applications of stem cells including those in drug discovery are also described. Various types of cells used, methods of preparation and culture, encapsulation and genetic engineering of cells are discussed. Sources of cells, both human and animal (xenotransplantation) are discussed. Methods of delivery of cell therapy range from injections to surgical implantation using special devices. Cell therapy has applications in a large number of disorders. The most important … Continue reading

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Celyad’s CAR T-cell Therapy Shows Promise in 2 Patients with Advanced Colorectal Cancer – Ovarian Cancer News Today

Posted: Published on July 6th, 2017

New data from the Phase 1 THINK clinical trial (NCT03018405) show that two metastatic colorectal cancer (mCRC) patients whose disease progressed following at least two prior therapies had stabilized the disease at a three-month follow-up after receiving the lowest dose level ofCelyads NKR-2 CAR T-cell therapy. The third person included in the dose cohort, a pancreatic cancer patient, had disease progression at three months, but the findings suggest that this CAR T-cell therapy inducesbetter results than standard of care, under which the time to disease progression is between 1.9 and 3.2 months. We are pleased to have observed these encouraging preliminary results in such a late stage population, Christian Homsy, Celyads CEO, said in apress release.Despite being dosed only at a tenth of the expected efficacious dose based on animal experiments, the results show a stabilization of the disease. We look forward to the next stages of the trial. The open-label THINK trial, conducted in the U.S. and Europe, is a dose escalation Phase 1 study to assess the safety and clinical activity of three administrations of NKR-2 cells across seven cancer types. The study is designed to include patients with five types of solid tumors (colorectal, ovarian, bladder, triple-negative … Continue reading

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Women graduates ‘desperately’ freeze eggs over ‘lack of men’ – BBC News

Posted: Published on July 5th, 2017

BBC News Women graduates 'desperately' freeze eggs over 'lack of men' BBC News "Rather, they were desperately preserving their fertility beyond the natural end of their reproductive lives, because they were single without partners to marry." Speaking at the European Society of Human Reproduction and Embryology conference in ... 'Oversupply' of educated women freezing eggs thanks to 'deficit' of equally qualified menNational Post Career women 'freeze eggs as they wait for successful man' - studyIndependent Online Women are freezing their eggs as they can't find a man | Daily Mail ...Daily Mail Telegraph.co.uk all 12 news articles » See the rest here: Women graduates 'desperately' freeze eggs over 'lack of men' - BBC News … Continue reading

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Aytu BioScience Presents Clinical Findings for its MiOXSYS System at 33rd Annual Meeting of the European Society … – PR Newswire (press release)

Posted: Published on July 5th, 2017

Josh Disbrow, Chief Executive Officer of Aytu BioScience, stated, "These latest research findings continue to add to the clinical and scientific evidence supporting use of our MiOXSYS System, which we've already demonstrated to be a useful clinical tool for assessing oxidative stress levels in semen as it relates to male infertility. These seven presentations at ESHRE, presented by leading andrologists and urologists from infertility centers around the world, demonstrate the broad interest and significant potential for clinical use of the MiOXSYS System as an aid in the diagnosis of male factor infertility." The poster presentations were as follows: Title: ORP: A Reliable and Reproducible Method of Evaluating Oxidative Stress - A Multicenter Study Poster Number: G17-0526 Session: 36 Presenter: Ashok Agarwal, Ph.D., Director of the Andrology Center and Director of the American Center for Reproductive Medicine at the Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland, OH Conclusion: Although other semen parameters showed significant differences between the two centers, sORP remained consistent in both data sets individually or in combined data. This proves its reproducibility and reliability. sORP is a measure of semen quality which adds more weight to semen testing in identifying fertile from infertile semen samples. Title: Effect … Continue reading

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Artificial intelligence better than scientists at choosing successful IVF embryos – Independent Online

Posted: Published on July 5th, 2017

Scientists are using artificial intelligence (AI) to help predict which embryos will result in IVF success. In a new study, AI was found to be more accurate than embryologists at pinpointing which embryos had the potential to result in the birth of a healthy baby. Experts from Sao Paulo State University in Brazil teamed up with Boston Place Clinic in London to develop the technology in collaboration with Dr Cristina Hickman, scientific adviser to the British Fertility Society. They believe the inexpensive technique has the potential to transform care for patients and help women achieve pregnancy sooner. During the process, AI was "trained" in what a good embryo looks like from a series of images. AI is able to recognise and quantify 24 image characteristics of embryos that are invisible to the human eye. These include the size of the embryo, texture of the image and biological characteristics such as the number and homogeneity of cells. During the study, which used cattle embryos, 48 images were evaluated three times each by embryologists and by the AI system. The embryologists could not agree on their findings across the three images, but AI led to complete agreement. Stuart Lavery, director of the … Continue reading

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4-Hers ‘liberate’ excess eggs for those in need – Port Townsend Leader

Posted: Published on July 5th, 2017

The Chicken Champions are visiting farms and households with poultry on July 9 to pick up eggs for donation to food banks in Jefferson County. The community-service project led by Peninsula Poultry 4-H Club (a.k.a. Chicken Champions) invites anyone with egg-laying poultry to share their bounty and help the hungry. Eggs are to be brought to the food banks on Wednesday, July 12. They approached me with the idea, and I told them that eggs were like liquid gold at the food bank, said Shirley Moss, director of the Port Townsend Food Bank. An egg can be used for breakfast, lunch or dinner; it keeps well its just an amazing food source, she said. 4-H club members came up with the idea of collecting the eggs as a way to give back to the community. One of the elements of 4-H that we try to cultivate is to grow the kids as generous people to help them experience what it means to be generous in the community, said Tanya Barnett, 4-H youth coordinator and Chicken Champion parent. The project is called the Great Egg Liberation, and, in the spirit of Independence Day, club members see the project as a liberation … Continue reading

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Undergoing fertility treatment does not increase a couple’s risk of getting divorced, according to a new study. – Lancashire Telegraph

Posted: Published on July 5th, 2017

UNDERGOING fertility treatment does not increase a couple's risk of getting divorced, according to a new study. The findings dispel the belief that the stress of undergoing treatments such as in vitro fertilisation (IVF) can put intolerable strain on relationships. The study, presented to the European Society of Human Reproduction and Embryology annual meeting in Geneva, drew on findings from a registry of women having assisted reproduction treatment in Denmark between 1994 and 2009. Researchers examined data on 42,845 patients including their marital status and compared it to a control group from the general population. During the 16 years of follow-up the majority of couples had children - 56 per cent from the general population and 65 per cent of those undergoing fertility treatment. And around one-fifth from each group ended up separated or divorced - 20 per cent of those who had fertility treatments compared to 22 per cent of the general population. Although initial findings did reveal a lower risk of break-up among the couples who had assisted reproduction treatment, when subsequent children were added to the model, and after adjusting for both partners' age, education and partnership status, no difference in the risk of marriage or partnership … Continue reading

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Cancer survivors 38% less likely to get pregnant | IOL – Independent Online

Posted: Published on July 5th, 2017

Women who survived cancer were 38 percent less likely to become pregnant as compared to their healthy counterparts, says a new study. The research findings also emphasised on the need for better access to fertility preservation in girls and young women. The detrimental effect on fertility was evident in almost all types of cancer diagnosed, the study showed. The findings showed that for women who had not been pregnant before their cancer diagnosis, 20.6 percent of the cancer survivors achieved a first pregnancy after diagnosis, compared with 38.7 percent in the control group. Thus, women with cancer were about half as likely to achieve a first pregnancy. "This analysis provides evidence of the effect of cancer and its treatment on subsequent pregnancy across the full reproductive age range," said Richard Anderson, Professor at the University of Edinburgh. Chemotherapy and radiotherapy - treatments for cancers - are known to affect fertility as some can cause damage to the ovary, uterus and potentially affect those brain centres which control the reproductive axis. The results were presented at the Annual Meeting of European Society of Human Reproduction and Embryology (ESHRE) in Geneva. For the study, the team included 23 201 female cancer survivors … Continue reading

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