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Eva Feldman reflects on experience as director of Taubman Institute – The Michigan Daily

Posted: Published on June 23rd, 2017

Eva Feldman has been at the forefront of the University of Michigans stem cell research for decades. Since receiving her M.D. and Ph.D. degrees from the University and, later, becoming director of research for the University Amyotrophic Lateral Sclerosis Clinic and director of the A. Alfred Taubman Medical Research Institute, Feldman has conducted her research with one thing in mind: finding a cure for ALS. Though Feldman recently announced she will be stepping down from the latter position, her extensive research and numerous accomplishments as director of the Taubman Institute will not be forgotten by peers, mentees and most importantly her patients. Stem cell research, though controversial, has always been a noteworthy point of scientific and medical innovation and development at the University despite pushback from human rights groups and government action. Feldman herself has been conducting her research for years, starting first as a fellow at the University in 1987, then later joining as a faculty member, practicing clinical trials and speaking at events to stress the significance of stem cell research. She conducts research primarily on amyotrophic lateral sclerosis, commonly known as Lou Gehrig's disease a neurodegenerative disease which the Centers for Disease Control and Prevention estimates 5,000 … Continue reading →

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How the Biology in Every Single ALIEN Movie Fits Together – Nerdist – Nerdist

Posted: Published on June 22nd, 2017

Look, fans of the ALIEN franchisewe need to have a chest-to-chest for a minute. Its getting harder and harder to love the movies if youre a giant science nerd, like me. For the last 40 years,the movies have been getting more and more hung up on the biology of the original xenomorph (yes, small x), as have we nerds, and now its all a mess. What is the black goo? Where did the first facehugger come from? Alien: Covenant is the latest film to try and sort it all out, but audiences are still confused. So lets fix that. Lets look at every ALIEN film ever madelook to the quotes from the people who actually made the moviesand produce the longest-ever Because Science to create the definitive, conclusive xenomorph life cycle. Maybe. I hope. In my latest Because Science, Ive gone a bit crazy trying to link every chestburster with every hybrid with every egg. If you look at the original conception of the monsters from ALIEN and ALIENS, the life cycle was very straightforward. ALIEN writer Dan OBannon and director Ridley Scott were fascinated by the biology of parasitoid waspsparalyzing prey, laying eggs on/in them, and cocooning bothand so … Continue reading →

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Beautycounter’s scientists invented a moisturizer that mimics your skin’s biology – Fast Company

Posted: Published on June 22nd, 2017

On Sunday night's episode of Last Week Tonight, John Oliver targeted the coal industry. Now they are striking back. In the episode, he pleaded with President Trump to "stop lying to coal miners" about his ability to revive the shrinking industry. Oliver also targetedBob Murray, the notoriously litigious CEO of Murray Energy, even though he knew he was likely to be sued for doing so, as the company sent the show a cease-and-desist order before the episode even aired. Murray runs the country's largest privately owned coal company, Murray Energy Corporation, and has sued media companies in the past, including recently filing a libel suit againstthe New York Times.Despite that cautionary tale, on the June 18 episode of Last Week Tonight,Oliver said Murray doesn't do enough to protect his miners' safety. He illustrated that point witha government report that concluded thatthe collapse of one of Murray's mines in Utah, which killed nine people, was due tounauthorized mining practices, while Murray claims the collapse actually happened because of an earthquake. A legal complaint filed on June 21 in the circuit court of Marshall County, West Virginia, states thatOliver and his team "executed a meticulously planned attempt to assassinate the character of … Continue reading →

Posted in Biology | Comments Off on Beautycounter’s scientists invented a moisturizer that mimics your skin’s biology – Fast Company

Seniors who failed biology assessment test would get diplomas under new deal – The Spokesman-Review

Posted: Published on June 22nd, 2017

UPDATED: Thu., June 22, 2017, 5:37 p.m. Rogers High School. Members of the class of 2017 who failed the biology assessment test but had all other requirements to graduate will get their diplomas, after lawmakers agreed to de-link that test from graduation requirements through 2021. (Colin Mulvany / The Spokesman-Review) OLYMPIA High school seniors who failed to pass a biology assessment test this year are likely holding their breath and crossing their fingers, wondering if their diplomas will materialize. The verdict is in, and they can breathe out and uncross. Odds are pretty good theyll be full-fledged high school graduates in a couple weeks, thanks to a deal legislators announced Thursday that makes changes to the testing system. If you havent passed your math or English language assessment test, however, youll still need to do more to get that diploma. Members of the class of 2017 who failed the biology assessment test but had all other requirements to graduate will get their diplomas. Lawmakers agreed to de-link that test from graduation requirements through 2021. Those who didnt pass the math or English assessment test will have more chances to demonstrate they are proficient in those subjects. Starting in 2019, those … Continue reading →

Posted in Biology | Comments Off on Seniors who failed biology assessment test would get diplomas under new deal – The Spokesman-Review

Kate Walsh Talks Playing ''Wicked Bitch'' Addison Montgomery on Grey's Anatomy – E! Online

Posted: Published on June 22nd, 2017

Kate Walsh will always have a bit of Addison Montgomery in her. The actress rose to fame onGrey's Anatomystarring as the girl every avid watcher loved to hate. After two seasons as a main character opposite Ellen Pompeo andPatrick Dempsey, Walsh parlayed Addison into her own spinoff,Private Practice. Now four years after the hit medical drama said goodbye to the infamous neonatal surgeon, Walsh is reflecting on the role that changed her life. During a Q&A with Buzzfeed, Kate said she'll never forget her entrance at the end of seasonone.Grey's fans will vividly remember when she (and her fiery red locks) surprised estranged husband Derek Shepherd (Dempsey) and his new girlfriend, Meredith Grey, (Pompeo) at the hospital. She recalled, "I got more calls and attention from that 60-second scene than anything in my career before.Isn't that funny?" Walsh continued, "Everyone hated me, but at that time there was no Twitter. There were chat rooms, but I never really went on them. I kind of liked being the Wicked Witch from the East. Or the wicked bitch. [Show creator] Shonda [Rhime's] really gifted at flipping every character that's seemingly awful. It's a great lesson in how to have compassion for people … Continue reading →

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Sarepta signs another Duchenne gene therapy pact as it aims for wider treatment – FierceBiotech

Posted: Published on June 22nd, 2017

Sarepta Therapeutics has penned its second DMD gene therapy pact this year as it announces a tie-up with Frances Genethon, a nonprofit R&D org. The research collaborationwill see the Franco-American pair jointly develop treatments for Duchenne muscular dystrophy and comes after Sareptas first FDA approval for DMD with its controversial med Exondys 51 (eteplirsen). RELATED: FDA expert lashes out at 'worrisome' Sarepta approval in JAMA Sarepta is looking to tap into Genethons preclinical microdystrophin gene therapy approach, which can target the majority of patients with DMD. Its current med can only treat certain patients, namely those with the mutation of the dystrophin gene amenable to exon 51 skipping, which affects about 13% of the population with DMD. It is hoping that with new tie-ups, it could produce a gene therapy that could treat many more, if not all, patients with the disease, although this is still some years off. DMD is a rare genetic disorder characterized by progressive muscle deterioration and weakness. The disease primarily affects young boysand occurs in about one out of every 3,600 male infants worldwide. This builds on the pacts announced at the start of the year at the JPM conference, which saw it sign a … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on Sarepta signs another Duchenne gene therapy pact as it aims for wider treatment – FierceBiotech

New Analyses of Translarna (ataluren) Data from ACT DMD Presented at the 12th Annual European Pediatric … – PR Newswire (press release)

Posted: Published on June 22nd, 2017

About Duchenne Muscular Dystrophy Primarily affecting males, Duchenne muscular dystrophy (DMD) is a rare and fatal genetic disorder that results in progressive muscle weakness from early childhood and leads to premature death in the mid-twenties due to heart and respiratory failure. It is a progressive muscle disorder caused by the lack of functional dystrophin protein. Dystrophin is critical to the structural stability of skeletal, diaphragm, and heart muscles. Patients with DMD can lose the ability to walk as early as age ten, followed by loss of the use of their arms. DMD patients subsequently experience life-threatening lung complications, requiring the need for ventilation support, and heart complications in their late teens and twenties. It is estimated that a nonsense mutation is the cause of DMD in approximately 13 percent of patients. About ataluren (Translarna)Ataluren, discovered and developed by PTC Therapeutics, Inc., is a protein restoration therapy designed to enable the formation of a functioning protein in patients with genetic disorders caused by a nonsense mutation. A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein. The resulting disorder is determined by which protein cannot be expressed in its entirety and is … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on New Analyses of Translarna (ataluren) Data from ACT DMD Presented at the 12th Annual European Pediatric … – PR Newswire (press release)

Henry Viscardi student calls cerebral palsy ‘biggest blessing’ – Newsday

Posted: Published on June 22nd, 2017

Emma Greenfield says one of the biggest blessings in her young life has been her disability. She was born 27 weeks premature and has used a wheelchair since the age of 5 after being diagnosed with cerebral palsy. Im not going to lie, it was challenging at times, said Greenfield, 17, who undergoes occupational and physical therapy on a weekly basis. But now that Im older, it has really become my biggest blessing, because its helped open my eyes to others and be aware of other peoples issues. The gregarious Greenfield, who said the main challenge of living with a disability is dealing with public perceptions, has strived to be the change she seeks in society by taking on an advocacy role at her alma mater in Albertson, a state-funded special-education school for severely disabled students. One of those efforts involved being a Viscardi Ambassador. About 20 ambassadors visit schools in rotating groups to show students were just like everybody else, said Greenfield, of Hicksville. Since becoming an ambassador last year, she said she has answered all types of questions, ranging from How do you take a shower? to What is your favorite food? But ambassadorship aside, Greenfield said the … Continue reading →

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Evanston senior-to-be with cerebral palsy perseveres in pool, on track – Chicago Tribune

Posted: Published on June 22nd, 2017

It was Aaron Holzmueller's first time in the high school pool, and things didn't go as planned. Holzmueller has cerebral palsy, a neurological disorder of movement, muscle tone or posture caused by damage to the brain, most often before birth, according to the Mayo Clinic website. Seizures had been part of Holzmueller's childhood, yet when he entered the Evanston Township High School pool in early May 2013 a week before his 13th birthday, he hadn't had one in 11 years. But there was a recurrence during the practice with the feeder team. Holzmueller had a seizure underwater, and Evanston assistant swimming coach Joe Springer jumped in to save the then-seventh-grader. Holzmueller was loaded into an ambulance and rushed to the hospital. Wildkits swimming coach Kevin Auger called Holzmueller's father, Keith, who relayed the news to Holzmueller's mother, Birdy. "On the way down to Lurie, I got another call from (Springer), he wanted to check in," Birdy Holzmueller said. "He said, 'You know, I hope this doesn't keep him from coming out to swim again, because he's one of our Wildkits now.' "So here we are, I had just reassured them that he hadn't had seizures in years and years, he … Continue reading →

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Cerebral Palsy – What Do We Know About the Causes? – Lexology (registration)

Posted: Published on June 22nd, 2017

A diagnosis of cerebral palsy (CP) is usually only made after a doctor has carried out a range of specialised tests with a team of health professionals. These professionals may include neurologists, paediatricians, genetic specialists and a host of others. The most common symptoms of CP are slow development, abnormal muscle tone and postural abnormalities which may include low muscle tone (hypotonia) or high muscle tone (hypertonia). There is no one cause to cerebral palsy but research has shown that in most cases, about 70%, the causes can be traced to the period before birth (the prenatal period). About 20% of cerebral palsy cases occur during the birthing process (perinatally). These will include a situation where the babys brain is injured because there has been lack of oxygen during delivery. This is otherwise known as hypoxic ischaemic encephalopathy. Within this 20% of cases are also babies who acquire cerebral palsy as a result of being delivered prematurely. The further 10% of cases are post-birth and can arise from traumatic injury or infections during the early years of life. Examples of this cause would be bacterial meningitis or viral encephalitis. Unfortunately, in many cases the cause of a particular childs cerebral … Continue reading →

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