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ANATOMY OF AGITATIONS – Oherald

Posted: Published on June 17th, 2017

Share this story rom industries to bridges, mega projects to widening of roads and pipelines, it sometimes seems that everywhere you look, some group in Goa is rallying against something. What is behind this new opposition-ism? Goans social values, and their evolution over the past few decades, tell an important part of the story. Social values are the deep-seated beliefs and orientations that underline our opinions on the issues of the day. While at one time many Goans would conform to the expectations of authority figures, and follow the customs and demands of institutions and ideologies, these days they are increasingly unwilling, or uncomfortable, deferring to authority and instead are interested in making their own choices onwhat they want. The people want development they want motorable roads, uninterrupted water and power supply what they dont want is an abrupt change in their lives wrought about by a project that they are unlikely to ever benefit from. Goans do not generally accept the notion that pollution is inevitable, or acceptable, in an industrial society. Second, Goans do not tend to hold the belief that environmental damage is an acceptable price to pay for economic growth. Third, Goans, by and large, tend … Continue reading →

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Anatomy of cricket: An XI of human body parts – Cricket Country

Posted: Published on June 17th, 2017

Clockwise from top left: David Brain, Travis Head, Josh Tongue Getty Images, Don Beard (photo courtesy: Wikimedia Commons) The idea struck me when I came across Worcestershires Josh Tongue on a scorecard. You cannot blame me for doing a double-take. For a second I thought there was a spelling error of some sort, for the Antiguan Gavin Tonge had played a handful of matches for West Indies in 2009. But no, it was Tongue all right. But then, if there can be a Tongue, why not make an XI of all sorts of body parts that have made their way to scorecards? I wanted to restrict myself to human beings, which meant that I had to leave out Wendell Bill (and many other Bills), and a handful of Gills who have played international cricket at Under-19 level (Akash for Canada, Neil for Ireland, and Shubnam for India). There was also Gill Smith presumably unrelated to Will who played 4 Tests and 31 ODIs for England Women). Also Read No, I will keep this human. And for a completely different reason we will leave Jake Ball out, along with a cohort of Dicks and others that satisfy the same criterion. I … Continue reading →

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Researchers Aim to Repurpose Failed Leukemia Drug to Treat … – Managed Care magazine

Posted: Published on June 17th, 2017

Muscular Dystrophy News Researchers Aim to Repurpose Failed Leukemia Drug to Treat ... Managed Care magazine Researchers at the National Institutes of Health's National Center for Advancing Translational Sciences (NCATS) and at the University of Nevada Reno School ... A Drug Unsuccessful at Treating Cancer May Successfully Treat DMDAJMC.com Managed Markets Network Duchenne MD Mice Improve Muscle Function with Former Cancer ...Muscular Dystrophy News all 3 news articles » See the original post here: Researchers Aim to Repurpose Failed Leukemia Drug to Treat ... - Managed Care magazine … Continue reading →

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Researchers aim to repurpose former experimental cancer therapy to treat muscular dystrophy – ScienceBlog.com (blog)

Posted: Published on June 17th, 2017

Researchers at the National Institutes of Healths National Center for Advancing Translational Sciences (NCATS) and the University of Nevada, Reno School of Medicine (UNR Med) have demonstrated that a drug originally targeted unsuccessfully to treat cancer may have new life as a potential treatment for Duchenne muscular dystrophy (DMD). The candidate drug, SU9516, represents a different kind of approach for treating DMD, a degenerative muscle disease that usually begins in childhood and has no known cure. It is caused by a faulty gene that leads to progressive muscle weakness, with death often occurring around age 25. Rather than trying to fix or replace the broken gene, SU9516 ramps up the muscle repair process, helping reinforce muscle structure. NCATS Chemical Genomics Center Acting Branch Chief Juan Marugan, Ph.D., and UNR Med Professor of Pharmacology Dean Burkin, Ph.D., led a team that screened more than 350,000 compounds to find SU9516, which had been previously developed as a treatment for leukemia. The research demonstrated that this compound improved muscle function in both laboratory and animal DMD models. The results, published recently in Molecular Therapy, may provide a promising approach against the disorder and other muscle-wasting conditions. Those with DMD lack dystrophin, a protein … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on Researchers aim to repurpose former experimental cancer therapy to treat muscular dystrophy – ScienceBlog.com (blog)

RASRx Receives Orphan Drug Designation from FDA – Business Wire (press release)

Posted: Published on June 17th, 2017

NEWPORT BEACH, Calif.--(BUSINESS WIRE)--RASRx announced today that the United States Food and Drug Administration (FDA) has granted an Orphan Drug Designation (ODD) for its compound RASRx1902 for the treatment of Duchenne Muscular Dystrophy. RASRx1902 is an oral therapy that has shown positive effects on muscle function in animal models of Duchenne. In these models, the RASRx1902 has improved muscle strength and regeneration while decreasing muscle inflammation, degeneration, and necrosis. Through this ODD, RASRx is eligible for financial incentives that can stimulate investment in this program and expedite its regulatory timeline. In concert with CureDuchenne, the company is now transitioning to toxicology studies to advance RASRx1902 towards human clinical trials for the treatment of Duchenne. RASRxs founders worked with the USC Stevens Center for Innovation, the technology transfer office for the University of Southern California, to exclusively license RASRx1902. Funding by CureDuchenne Ventures and a collaborative U.S. Department of Defense research grant with USC has accelerated the preclinical development of this program. Innovation is a core part of USCs culture and we are proud to support Dr. Kathleen Rodgers and RASRx to facilitate the technology transfer of RASRx1902 for DMD, said Michael Arciero, J.D. Director of Technology Commercialization and New Venture, … Continue reading →

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Cerebral Palsy Didn’t Stop This College Junior. Obamacare Repeal Might. – HuffPost

Posted: Published on June 17th, 2017

HILLIARD, Ohio Justin Martin, 21, is in many respects a typical junior at Kenyon College. He lives in an off-campus apartment, which he shares with six other guys. Hes majoring in English, helps run a student improv group, and last semester he took five courses instead of the usual four a terrible idea, he now concedes. Sometimes he pulls all-nighters to write papers or study for exams, drawing sustenance from soda and chocolate-covered almonds. And sometimes he stays up late just to have long arguments with his roommates like over whether its OK to ban campus speeches by white supremacists (Martin says no) or whether the seventh Harry Potter novel was the worst (Martin says yes). But in one respect, Martin is unique on the Kenyon campus and rare among college students in general. He has cerebral palsy, the disease that severely impairs muscle movement. Martin cannot walk or care for himself without assistance. His life in college getting to room with his fellow students, carrying a more-than-full course load is a testimony to many things, including supportive administrators and his own stubborn determination. But, Martin says, none of this would be possible if it wasnt for the help of … Continue reading →

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Toddler with cerebral palsy takes first steps wearing ‘magic shoes’ – 9news.com.au

Posted: Published on June 17th, 2017

A disabled girl has taken her first independent steps wearing revolutionary shoes made by a small company in Sydneys west. Eve Darcy was diagnosed with cerebral palsy whenshe was just weeks old, and could only take small steps aided by a walking frame. Big or small, everyday activities were a milestone- until she found Magic Shoes, created by a start-up AbilityMate. She was in daycare on Wednesday, she walked in with her frame, she didn't go Thursday, and she walked in on her own on Friday. It happened so fast, she just took off, Eves dad, Joe Darcy, told 9NEWS. A pair of AbilityMate's Magic Shoes. (9NEWS) Magic Shoes use 3D printing technology to create tailored orthotics in a fraction of the time. Measurements of the childs foot are taken using scanners, which are sent off to a 3D printer. Magic Shoes are then manufactured at a factory in Guildford and can be fitted in less than two months. The fast turn-around is of huge benefit for sufferers of cerebral palsy, who often have to wait a year for a pair of properly fitted shoes. To be using state of the art technology, to be creating much faster, much cheaper, … Continue reading →

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Inmate, 75, died after cops used force, nurses didn’t properly treat … – Orlando Sentinel

Posted: Published on June 17th, 2017

Family and neighbors say William Howard was never aggressive and always offered to help anyone who needed it. But in November, Howard was accused in a brutal attack against his wife of 47 years. She was left with multiple stab wounds and told deputies she didnt understand why he attacked her. They were in love. She knew he loved her very much. We all dont understand. It just left us all completely baffled, said Howards brother, Waverly Howard, 68. And now well never get the chance to understand what happened. Thats because three days after Howard, 75, was booked on an aggravated battery charge in the Orange County Jail, he was found unresponsive in his cell and later pronounced dead, documents show. Correctional officers at the jail did a take-down on Howard when he was being moved to a psychiatric observation cell, which caused a neck fracture and his death, according to a 20-page review from the Orange County Sheriffs Office and an autopsy report. The force was used after he didnt cooperate as officers tried to move him to another cell, said Tracy Zampaglione, a spokeswoman for the jail. Several officers are under internal investigation in the incident and … Continue reading →

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The Many Personalities of Brain Injury: Why I Sometimes Want to Throw in the Towel – The Good Men Project (blog)

Posted: Published on June 17th, 2017

There is a saying in the brain injury community: If youve seen one brain injury, youve seen one brain injury. The premise of this saying is that no two traumatic brain injuries are the same, no two recoveries are the same, and no two treatment plans are the same. TBI is a complex and grossly misunderstood injury. After sustaining a traumatic brain injury from a fall on the ice in February of 2014, I have become an active advocate for the brain injury community. I have witnessed first hand the many ways that TBI is misunderstood, and I have also witnessed the many different personality changes that can result from it. Depending on where the brain has been injured, survivors can exhibit an array of behavioral and emotional symptoms including anger, rage, sensitivity, apathy, depression, lack of focus, loss of filtering, to name just a few. I have noticed that I myself am much more sensitive, and I am also more aware of the abusive behavior in other, seemingly well-meaning people. As the administrator of a fairly large Facebook group for those with TBI, I have had my share of struggles in dealing with personal attacks from fellow brain injury … Continue reading →

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A narrative literature review of depression following traumatic brain injury: prevalence, impact, and management … – Dove Medical Press

Posted: Published on June 17th, 2017

Shannon B Juengst,1,2 Raj G Kumar,3 Amy K Wagner35 1Department of Physical Medicine and Rehabilitation, 2Department of Rehabilitation Counseling, University of Texas Southwestern Medical Center, Dallas, TX, 3Department of Physical Medicine and Rehabilitation, 4Department of Neuroscience, 5Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA, USA Abstract: Depression is one of the most common conditions to emerge after traumatic brain injury (TBI), and despite its potentially serious consequences it remains undertreated. Treatment for post-traumatic depression (PTD) is complicated due to the multifactorial etiology of PTD, ranging from biological pathways to psychosocial adjustment. Identifying the unique, personalized factors contributing to the development of PTD could improve long-term treatment and management for individuals with TBI. The purpose of this narrative literature review was to summarize the prevalence and impact of PTD among those with moderate to severe TBI and to discuss current challenges in its management. Overall, PTD has an estimated point prevalence of 30%, with 50% of individuals with moderate to severe TBI experiencing an episode of PTD in the first year after injury alone. PTD has significant implications for health, leading to more hospitalizations and greater caregiver burden, for participation, reducing rates of return to work and affecting social … Continue reading →

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