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Cell biology: A molecular rivet for long-range force transmission – Science Daily

Posted: Published on May 9th, 2017

Cell biology: A molecular rivet for long-range force transmission Science Daily To investigate these questions, a team of interdisciplinary scientists from MBI, A*STAR's Institute of Molecular and Cell Biology, and the European Molecular Biology Laboratory, examined the cortex in a developing organism, specifically, Caenorhabditis ... Read the rest here: Cell biology: A molecular rivet for long-range force transmission - Science Daily … Continue reading

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Biology will take some mistakes to maintain speed – Futurity: Research News

Posted: Published on May 9th, 2017

When it comes to duplicating DNA, evolution seems to value speed over accuracy, new research suggests. The finding challenges assumptions that perfectly accurate transcription and translation are critical to the success of biological systems. It turns out a few mistakes here and there arent critical as long as the great majority of the resulting biopolymers are correct. A new paper in the Proceedings of the National Academy of Sciences shows how nature has optimized two processes, DNA replication and protein translation, that are fundamental to life. By simultaneously analyzing the balance between speed and accuracy, Rice University researchers determined that naturally selected reaction rates optimize for speed as long as the error level is tolerable. Their technique allowed them to see that while error correction through kinetic proofreading leans toward speed, the cost of going as fast as possible could sometimes be too big. Kinetic proofreading is the biochemical process that allows enzymes, such as those responsible for protein and DNA production, to achieve better accuracy between chemically similar substrates. Sequences are compared to templates at multiple steps and are either approved or discarded, but each step requires time and energy resources and as a result various tradeoffs occur. Additional … Continue reading

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A new bioinformatics tool to decipher evolutionary biology – Drug Target Review

Posted: Published on May 9th, 2017

news Understanding evolution is one of the cornerstones of biology evolution is, in fact, the sole explanation for lifes diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be engineered. One popular approach to the study of evolution is to compare genome data using bioinformatics tools. Scientists using these approaches may compare specific proteins, which consist of combinations of 20 universal building blocks, called amino acids. So far, the bioinformatics tools used to study the evolution of single proteins have assumed that the speed at which different regions of proteins evolve can be modelled with a statistical distribution whose shape is determined by a single variable. That assumption, however, does not reflect reality, and it might have led to a large proportion of biased phylogenetic results being published over the last two decades or so, explains Minh Quang Bui, from the Center for Integrative Bioinformatics (CIBIV). Arndt von Haeseler, group leader at the Max F Perutz Laboratories (MFPL) and Lars Jermiin from the Australian National University have now found a revolutionary way of implementing different rates of evolution into … Continue reading

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Bioengineering researchers showcase work | Scoop News – Scoop.co.nz (press release)

Posted: Published on May 9th, 2017

Tuesday, 9 May 2017, 3:28 pm Press Release: University of Auckland Bioengineering researchers showcase work at Waikato Mori school Researchers from the University of Aucklands Bioengineering Institute (ABI) will step outside their laboratories tomorrow and spend a day with 40 Year nine and ten pupils at Ng Taitea School in Hamilton. They will work hands-on with students demonstrating things like the intricate workings of our noses and eyes and how a baby breathes in vitro. This is the second year in a row the ABI, in partnership with Medical Technologies Centre of Research Excellence (MedTech CoRE) Outreach, has held an innovation day at Ng Taitea Wharekura. The Outreach programme aims to build strong relationships with students at high school level and then provide support as they progress to University, says Diana Siew, MedTechCoREs Strategic Relationships Manager, based at ABI. The MedTech CoRE Outreach has been co-designed with Ng Taitea Wharekura and aims to target the Mori community, particularly lower decile schools giving a little extra support to interested students to help them pursue STEM-related subjects. Our goal is not necessarily clinically oriented, says Siew. Students moving into tertiary education through our programme will have a chance to be mentored by … Continue reading

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ASME Launching Nerem Medal – Research Horizons

Posted: Published on May 9th, 2017

Posted May 9, 2017 Atlanta, GA Bob Nerem has won some of the top awards and honors in his field, recognitions for his dedication and accomplishments over a long career as a trailblazing bioengineer. But this summer, hell receive the kind of honor that will outlast him, when the American Society of Mechanical Engineers (ASME) commits his likeness to bronze. ASME has established the Robert M. Nerem Education and Mentorship Medal to recognize individuals who play a role in influencing engineering careers in the growing field of bioengineering, said K. Keith Roe, president of the society. A key criteria is mentoring in the form of activities that are innovative above and beyond what is normally seen. That would be Nerem, founding director of the Petit Institute for Bioengineering and Bioscience at the Georgia Institute of Technology. He is a member of the National Academy of Engineers (NAE) and one of only three bioengineers to receive the Founders Award from that organization. Hes also a member of the National Academy of Medicine, and a Fellow of the American Academy of Arts and Sciences. Nerem was instrumental in launching the American Institute for Medical and Biological Engineering (AIMBE), serving as its founding … Continue reading

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Macron Leaks: the anatomy of a hack – BBC News – BBC News

Posted: Published on May 9th, 2017

BBC News Macron Leaks: the anatomy of a hack - BBC News BBC News The US alt-right, WikiLeaks and bots helped to amplify the leaked emails from the Emmanuel Macron campaign. and more » Originally posted here: Macron Leaks: the anatomy of a hack - BBC News - BBC News … Continue reading

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The anatomy of cardamom – Huffington post (press release) (blog)

Posted: Published on May 9th, 2017

Tropical spices have been used in traditional medicine for centuries. Cardamom, the third most expensive spice in the world, is a reservoir of compounds that alleviate a variety of physiological discomforts. The recent pathetic self-congratulatory tone of the House Republicans with regards to their attempts to fashion a new healthcare act, is hopefully short-lived. In addition to potential procedural hurdles that the bill will likely face in the Senate, Republican senators have already expressed concern over language in parts of the bill. If the Senate passes a bill that is substantially different from the one passed by the House, then the bill would likely have to go back to the House. Historically, about 3% of bills introduced in Congress are enacted into law. The trajectory of the Affordable Care Act can be found at govtrack.us and is shown below [Note: the site is an independent site, and not a government siteit tracks bills and provides statistical analyses of legislation]. From the time of introduction of the bill, September 17, 2009, to it being approved by both the Senate and the House on March 20, 2010, Congress had convened for a total of 90 days. The current bill, H.R. 1628: American … Continue reading

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Special Report Preview: Anatomy of a Rape – WILX-TV

Posted: Published on May 9th, 2017

LANSING, Mich. (WILX) Its a tough crime to measure and a tough crime to prosecute. But Ingham Countys prosecutor says rape cases can be prevented with the right kind of education. Carol Siemon said, I think its huge, unless we change public perception, about what sexual assault looks like, cause I want to prevent it. Im not looking for successful prosecutions. Just weeks into her new reign as prosecutor, Siemon was handed two cases involving MSU football players. No charges have been issued in the first case, alleged in January. Charges in the second case, alleged in early April, were announced 2 weeks later. This has many people casting doubt about the first case, asking why its taking so long for the prosecutor to investigate. Prosecutor Siemon says its nothing new to her. She has years of experience prosecuting sexual assault. I think that we focus way too much on the victim, our laws do, our public perceptions do, on the victim's responsibility, and not on the person who is initiating the sexual activity. Siemon sits down with News 10s Ann Emmerich to talk about her philosophy on prosecuting sexual assault cases, and what she thinks can help prevent the … Continue reading

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Debbie Allen on Grey's Anatomy, Her Trailblazing Career, and the Increasing Diversity in TV – ELLE.com

Posted: Published on May 9th, 2017

On June 6, the multitalented Debbie Allen will be honored with the Lifetime Achievement Award at the 42nd annual Gracie Awards Gala, hosted by The Real's Jeannie Mai. But if you're thinking that someone who has appeared on everything from Fame to The Love Boat to Grey's Anatomy (which Allen also directs) would be blas about this kind of recognition, you'd be wrong. "This is really exciting for me," Allen tells ELLE.com. "I don't get much time to look back and celebrate myself because there's always something to do or a fire to put out or a project to start. There's always so much to do. So it's a nice moment for me." Advertisement - Continue Reading Below Allen, 67, got her start on Broadway as a dancer, singer, and actress, and has since become instrumental in television shows both as an actor and behind the scenes as a director and producer. She became the first African American woman to receive a Golden Globe for Best Performance by an Actress in a Television SeriesMusical or Comedy in 1983 for her work on Fame, and today Allen is credited with mentoring dozens of young directors and creatives. Debbie Allen in 'Fame' … Continue reading

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GTx Announces Results from Preclinical Studies of SARMs in Duchenne Muscular Dystrophy Models Published in … – Yahoo Finance

Posted: Published on May 9th, 2017

MEMPHIS, Tenn.--(BUSINESS WIRE)-- GTx, Inc. (GTXI) today announced the publication in the journal Human Molecular Genetics of results from preclinical studies supporting the potential efficacy of the Companys SARMs, and in particular GTx-026, for Duchenne Muscular Dystrophy (DMD) treatment. DMD is a rare genetic disorder characterized by progressive muscle degeneration and weakness, affecting approximately 18,000 boys in the United States. Studies examined the treatment of castrated wildtype mice, x-linked muscular dystrophy (mdx) mice, and dystrophin and utrophin double mutant (mdx-dm) mice with GTx-026. Other SARMs in the Companys portfolio, GTx-024 (enobosarm) and GTx-027, showed similar positive effects on muscle mass, function, and histological characteristics. DMD typically afflicts boys around three to five years of age followed by declining physical functions before attaining puberty. Current treatment options for DMD rely on corticosteroids to reduce inflammation, but unfortunately the prolonged use of corticosteroids results in hyperglycemia, osteoporosis, and muscle wasting, which are all counterproductive in this disease, said Ramesh Narayanan, Ph.D., Director, Center for Cancer Drug Discovery and Associate Professor, Department of Medicine, University of Tennessee and a consultant for GTx, Inc. We hypothesize that an androgen receptor agonist may reverse musculoskeletal complications and extend survival in these boys, and in preclinical … Continue reading

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