They say that what happens in Vegas stays in Vegas. But this is definitely not true of the vagus nerve, which wanders from the stomach to the brain, passing through the heart, esophagus and lungs along the way. A new study offers fresh support for an intriguing theory about the vagus nerves role in Parkinsons disease, a neurological disorder that causes tremors, gait difficulties and sometimes dementia in roughly 1 million Americans and as many as 10 million people worldwide. This theory suggests the vagus nerve may be more than a highway for signals to travel to the brain from the many organs it touches. It may also be the conduit for transporting the protein alpha-synuclein from the stomach to the brain, where it forms telltale clumps in Parkinsons sufferers. If true, this theory would pinpoint a possible origin of the degenerative brain disorder in the gut. It would also confirm the centrality of this mysterious protein, whose precise role in Parkinsons is not well understood. And finally, it would suggest a possible way to block the progression of Parkinsons: a surgical procedure currently used to treat people with gastric ulcers that cuts the vagus nerve to sever the pathway … Continue reading
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