Preliminary tests of a potential new mesothelioma treatment have yielded some exciting results at the University of Hawaii Cancer Center. Mesothelioma researchers there are evaluating an immune system modulator called FTY720 or fingolimod. Derived from a fungus called Iscaria sinclairii, FTY720 has been used to treat the relapsing form of multiple sclerosis. Although FTY720 has shown what the research team calls therapeutic potential in some other forms of cancer, this is the first study evaluating the agent in the treatment of malignant pleural mesothelioma. To test the impact of FTY720 on mesothelioma tumors, the researchers first treated a panel of mesothelioma cell lines as well as normal human mesothelial cells. They assessed the action of the agent by measuring the activity of phosphatase protein 2A (PP2A), a major target for FTY720. The next step was to evaluate the activation of programmed cell death or apoptosis. A breakdown in apoptosis signaling is a major reason why cancers like malignant mesothelioma are allowed to grow out of control. Finally, the team gave the FTY720 treatment to mice that had been infected with human mesothelioma tumors to look for negative side effects. The University of Hawaii researchers found that FTY720 significantly suppressed the … Continue reading
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