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Stem Cell Treatment Has Potential to Help Parkinson’s Disease Unexpected Brain Area – Benzinga

Posted: Published on March 28th, 2017

Currently symptomatic therapies for Parkinson's Disease (PD) produce unwanted side effects and diminished effectiveness over time. A recent study published in STEM CELLS suggests that human neural stem cell (hNSC) transplantation could help to treat PD by stimulating subventricular zone (SVZ) stem cells to produce more neural cells. Durham, NC (PRWEB) March 28, 2017 Currently symptomatic therapies for Parkinson's Disease (PD) produce unwanted side effects and diminished effectiveness over time. A recent study published in STEM CELLS suggests that human neural stem cell (hNSC) transplantation could help to treat PD by stimulating subventricular zone (SVZ) stem cells to produce more neural cells. Strategies involving transplantation of these cells into the affected brain regions hold great promise; however, the exact mechanisms behind hNSCs' success are not fully understood. Neural stem cells are self-renewing and can differentiate into any type of neural cell, such as neurons and glial cells. With their ability to rescue dysfunctional neural pathways, NSCs are an ideal source for grafting and the development of novel therapies. A team led by Renzhi Wang from Peking Union Medical College Hospital and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences presented an animal model study to improve understanding of … Continue reading →

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‘Our dreams are coming true’: other Oxfordshire families who fundraised for cerebral palsy surgery – Witney Gazette

Posted: Published on March 28th, 2017

THE Balmer family are not alone in their quest to secure cerebral palsy treatment known as selective dorsal rhizotomy. Several families appeared in the Oxford Mail before, seeking the same surgery. Barton mum Paula Masih-Gill fundraised for SDR for her son Gabriel, now 17, who has cerebral palsy as well as a complex bone condition. He has since been accepted for surgery in Nottingham, scheduled for August. Mrs Masih-Gill, 41, said: Its a massive relief, we fought for this for five years. All our dreams are coming true. Initially we thought the operation was only done in America. The operation was pioneered decades ago in America but only recently made it across to the UK. Kidlington mum Sophie Haines, 30, made her first public appeal in 2013 for SDR funding for her son Camren. Now six, Camrens spastic quadriplegia cerebral palsy is still hampering his childhood as his family struggles to meet the cost of surgery in the USA. Mrs Haines said: We are still fundraising, Camren is not deemed eligible for SDR in the UK because he is too severely affected [by his condition]. With this surgery, Ive seen children go from commando crawling to walking unaided. I want … Continue reading →

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WWII chemical-weapon antidote shows early promise as treatment for spinal cord injuries – Purdue Exponent

Posted: Published on March 28th, 2017

A drug developed during World War II as an antidote for a chemical warfare agent has been found to be effective at suppressing a neurotoxin that worsens the pain and severity of spinal cord injuries, suggesting a new tool to treat the injuries. The neurotoxin, called acrolein, is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury's severity. Researchers have now found that the drug, dimercaprol, removes the toxin by attacking certain chemical features of acrolein, neutralizing it for safe removal by the body. The findings, detailed in a paper published online this month in the Journal of Neurochemistry, involved research with cell cultures, laboratory animals and other experiments. Dimercaprol may be an effective acrolein scavenger and a viable candidate for acrolein detoxification, said Riyi Shi, a professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, College of Veterinary Medicine and Weldon School of Biomedical Engineering. An extensive body of evidence exists suggesting the toxic nature of acrolein and its pathological role in a variety of disease processes, prompting the use of acrolein scavengers as a new therapeutic approach for alleviating … Continue reading →

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Potential drugs and targets for brain repair – Science Daily

Posted: Published on March 28th, 2017

Potential drugs and targets for brain repair Science Daily ... which can be exploited to develop new strategies for treatment. Second, they identify several new drugs, each already approved for clinical use, whose therapeutic potential for brain injury repair can now be explored. Finally, they provide a proof ... and more » Read the original here: Potential drugs and targets for brain repair - Science Daily … Continue reading →

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FDA Approves First Drug to Treat Severe Multiple Sclerosis – New York Times

Posted: Published on March 28th, 2017

New York Times FDA Approves First Drug to Treat Severe Multiple Sclerosis New York Times The Food and Drug Administration approved on Tuesday the first drug to treat a severe form of multiple sclerosis, offering hope to patients who previously had no other options to combat a relentless disease that leads to paralysis and cognitive decline. FDA Approves Ocrevus as 1st MS Treatment for Both Relapsing and Primary Progressive FormsMultiple Sclerosis News Today After 40-year odyssey, first drug for aggressive MS wins FDA approvalSTAT Roche Wins FDA Backing for New Multiple Sclerosis Therapy, Competition Could Crimp BiogenTheStreet.com Reuters -BioPharma Dive all 16 news articles » Read more: FDA Approves First Drug to Treat Severe Multiple Sclerosis - New York Times … Continue reading →

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Multiple sclerosis drug offers hope of halting disease – The Columbus Dispatch

Posted: Published on March 28th, 2017

JoAnne Viviano The Columbus Dispatch @JoAnneViviano Nathan Frim calls Dr. Michael Racke a miracle worker. The 44-year-old Frim, who has multiple sclerosis, used to take a pill every day, but his disease progressed. In the past, there wasn't much Racke or other doctors could do. But along came a drug called ocrelizumab. It's Racke's magic wand. The drug, expected to be approved by the U.S. Food and Drug Administration today, has been shown to halt the disease in patients with both relapsing MS and primary progressive MS, said Racke, a neurologist at Ohio Sate University's Wexner Medical Center. "It brings peace of mind," said Frim, who has relapsing MS. "Being on this medicine, I'm not worried about the progression. I feel that that's not an issue for me right now." Further, the dosing schedule an infusion every six months gives him a reprieve from worrying about the disease that doctors discovered he had in December 2014. For days at a time, he said, he doesn't even think about having MS. Frim, of Sunbury, received his latest dose of ocrelizumab on March 17.He's one of about 70 patients receiving the drug at Ohio State as part of clinical trials by drugmaker … Continue reading →

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Microrna treatment restores nerve insulation, limb function in mice with MS – Science Daily

Posted: Published on March 28th, 2017

Science Daily Microrna treatment restores nerve insulation, limb function in mice with MS Science Daily Study authors administered miR-219 into the spinal columns and cerebrospinal fluid of mice with nerve coatings damaged by a chemical called lysolecithin or by autoimmune encephalomyelitis induced in the animals, which is used to model MS. Treatment ... Myelin formation, limb function restored in MS mouse modelsMedical News Today all 3 news articles » More: Microrna treatment restores nerve insulation, limb function in mice with MS - Science Daily … Continue reading →

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Using stem cells to create an endless supply of blood – CNN

Posted: Published on March 28th, 2017

"This technology gives us that particular dream, or at least it brings us a lot closer," said Klein. To ramp up production, the UK researchers infected stem cells with cervical cancer genes. By inserting cancer genes from human papilloma virus (HPV) into bone marrow cells, Frayne and her colleagues were able to create the first adult red blood cells that could multiply an infinite number of times. These cells are referred to as "immortal." As the red blood cells mature, they spit out the nucleus -- the core that houses their DNA -- giving the cells a signature round, dimpled shape. Frayne and her colleagues filtered those cells from the rest, so the final batch did not contain the active cancer genes. Frayne said that a small number of these stem cells can be found in a simple blood draw, too; there's no need to do an invasive biopsy of the bone. Since her team completed the study last year, she said, they have already created two new immortal cell lines this way. But his cells didn't eject the nucleus well enough, and fetal blood cells have too tight a grip on oxygen; they are less likely to drop off … Continue reading →

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Researchers turn urine into research tools – Science Daily

Posted: Published on March 28th, 2017

UCLA Newsroom Researchers turn urine into research tools Science Daily One of the biggest challenges in studying Down syndrome is finding the right research model. Animals and established cell lines are limited in their ability to mimic human disease, and results don't always translate to patient populations. Stem cells ... Pioneering stem cell gene therapy cures infants with bubble baby diseaseUCLA Newsroom New Tools to Study the Origin of Embryonic Stem CellsTechnology Networks Researchers Look Up To Outer Space As Womb For Stem Cells ...University Herald Miami's Community Newspapers -Yahoo Finance -Medgadget (blog) all 25 news articles » Excerpt from: Researchers turn urine into research tools - Science Daily … Continue reading →

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Interferon-beta producing stem cell-derived immune cell therapy on liver cancer – Science Daily

Posted: Published on March 28th, 2017

Science Daily Interferon-beta producing stem cell-derived immune cell therapy on liver cancer Science Daily Hoping to improve primary liver cancer including HCC and metastatic liver cancer therapies, researchers from Japan began studying induced pluripotent stem (iPS) cell-derived immune cells that produced the protein interferon-? (IFN-). IFN- exhibits ... and more » See the rest here: Interferon-beta producing stem cell-derived immune cell therapy on liver cancer - Science Daily … Continue reading →

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