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‘It’s a miracle I survived’ – Coventry mum who mistook brain injury for hangover speaks about her treatment – Coventry Observer

Posted: Published on March 2nd, 2017

A WOMAN who nearly lost her life after mistaking a major brain injury for a hangover has talked about her journey for the first time. Five years ago, Gemma Beales suffered horrendous headaches following a night out with her husband Mike though put her pain down to a hangover. The 33-year-olds condition soon deteriorated, and she collapsed on the bathroom floor after suffering from seizures. The former Coventry resident was rushed to University Hospital by ambulance where her seizures were controlled and she was taken for an MRI scan. The scan found a bleed to Gemmas brain, as well as a large number of clots over her body, and she was admitted to Critical Care. More concerning news was revealed to Gemmas family the following day. She said: The next morning, a senior nurse rang my parents to say that Id seriously deteriorated and needed to have an emergency operation. They didnt know if Id survive, or what long-term effects the brain injury might have had, but that operation saved my life. Even my consultant said it was a miracle that Id survived. During the operation, Gemma needed to have part of her skull removed to relieve pressure on her … Continue reading

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More than half of prisoners may have had a brain injury – Herald Scotland

Posted: Published on March 2nd, 2017

HUNDREDS of prisoners in Scottish jails may have suffered severe brain injuries, leaving them unable to be effectively rehabilitated and more likely to reoffend. Those affected include dozens of women prisoners who have been victims of domestic violence. Others have neurological illnesses or brain injuries related to gang violence, or events in their criminal past, or childhood, which have often gone untreated, MSPs investigating healthcare in Scottish jails have been warned such individuals are unlikely to benefit from programmes to cut reoffending, unless more screening and treatment is offered for their conditions. The British Psychological Society says approximately 60 per cent of inmates of adult prisons and young offenders institutions will have suffered a head injury at some point in their life, with 45 per cent having had an injury so severe it left them unconscious. This is about three to four times the level found in the general population. Meanwhile seven to 16 per cent have suffered a severe head injury potentially hundreds of the current prison population of 7,742. The Health and Sport Committee at Holyrood is investigating healthcare in prisons. In a submission to this inquiry, the BPS calls attention to a report by the Glasgow-based National … Continue reading

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Findings reveal effect of embryonic neural stem cell development on later nerve regeneration capacity – Medical Xpress

Posted: Published on March 2nd, 2017

March 1, 2017 Neural progenitor cells (green) in the lateral ganglionic eminence (LGE), the region in the developing brain that produces the majority of adult neural stem cells. Credit: Sven Falk Neurodegenerative diseases such as Alzheimer's or Parkinson's, but also strokes or other types of traumatic brain damage, result in the death of nerve cells in the brain. Since the mammalian brain is capable of replacing nerve cells only in certain restricted regions, such nerve-cell loss is in most cases permanent. Similarly, the capacity to form new nerve cells in the mature brain is limited to specific areas. The cells responsible for neurogenesis in the mature brain are called adult neural stem cells, but little is known about their developmental origins. Now an international research collaboration led by Magdalena Gtz, Professor of Physiological Genomics at LMU's Biomedical Center and Director of the Institute for Stem Cell Research at the Helmholtz Zentrum Munich, has demonstrated that the mode of division of stem cells has a profound influence on the numbers of adult neural stem cells formed during embryonic development. The new findings appear in the journal Neuron. Neural cells develop from progenitors called neural stem cells, which are produced in large … Continue reading

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Study sees benefits in use of self-derived stem cells in horses – Horsetalk

Posted: Published on March 2nd, 2017

Researchers identified an adverse reaction in the fetlock joint of horses after giving them a second dose of mesenchymal stem cells from a donor. By contrast, no such reaction was found in horses receiving a second injection of the bone marrow-derived stem cells sourced from their own bodies, provided they had gone through a laboratory decontamination process first. Texas A&M University researchers have reported their findings, based on a study using 18 Quarter horses, in the journal Stem Cell Research & Therapy. The injection of mesenchymal stem cells into joints affected by osteoarthritis has been shown to be an effective therapy. However, Ashlee Watts and her colleagues noted that no direct comparison had been made of the response of the synovial joint to the injection of stem cells derived from the patients own body as opposed to a donor. The study team set out to assess the clinical response of each treatment, using stem cells prepared in a way that minimized protein contamination arising from laboratory techniques that used bovine serum as food for the cells in their preparation. The horses were divided into groups, with some receiving their own stem cells in a fetlock, some receiving donor cells from … Continue reading

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Facts About Cloning – Live Science

Posted: Published on March 2nd, 2017

Dolly the Sheep in a field at The Roslin Institute. Cloning is the process of taking genetic information from one living thing and creating identical copies of it. The copied material is called a clone. Geneticists have cloned cells, tissues, genes and entire animals. Although this process may seem futuristic, nature has been doing it for millions of years. For example, identical twins have almost identical DNA, and asexual reproduction in some plants and organisms can produce genetically identical offspring. And scientists make genetic doubles in the lab, though the process is a little different. There are three different types of cloning, according to the National Human Genome Research Institute (NHGRI): In gene cloning, a genetic engineer extracts DNA from an organism and then uses enzymes to break the bonds between nucleotides (the basic building blocks of DNA) and snip the strand into gene-size pieces, according to the University of Nebraska. Plasmids, small bits of DNA in bacterial cells, are combined with the genes. Then, they are transferred into living bacteria. These bacteria are allowed to grow into colonies to be studied. When a colony of bacteria containing a gene of interest is located, the bacteria can be propagated to … Continue reading

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Fitness blogger praised for sharing makeup-free photo after eczema flareup – Fox News

Posted: Published on March 1st, 2017

Everyone has bad days. But usually online, we only see peoples good ones. However, we all know thats not reality and thats precisely the inspiring message from Carys Gray, a fitness blogger whos being praised after sharing an honest makeup-free photo of herself during an eczema flareup. MODEL'S AMAZING JOURNEY FROM PREGNANT TO 6-PACK Gray, who has more than 148,000 followers on the social media platform, shows two photos of herself in the viral image: one with her eczema under control and makeup on her face, and another with her eczema flared up and her face makeup-free. Social media/Instagram will show the good days, Gray wrote in part in the now viral post, which had garnered over 80,000 likes as of Tueday afternoon. But here's a reminder that next time you see something on social media that you think is 'goals' that it's not the full story, it's not how that person will look or be alllllll the time! Eczema, or atopic dermatitis, is a chronic skin condition that causes redness and itchiness, according to the Mayo Clinic. It can occur at any age, and it does not have a cure. THIS FIT MOM DROPPED 6 DRESS SIZES BY LOSING … Continue reading

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Scientists are making personalised eczema treatments from … – ScienceAlert

Posted: Published on March 1st, 2017

Cultivating 'friendly' bacteria from people's skin makes it possible to develop personalised lotions to treat skin conditions like eczema, a new study shows. It's the latest evidence that beneficial bacteria in our microbiome can be used to treat infections spurred by harmful microbes, and could provide a new direction in antibiotics research: something we desperately need, in light of rising antimicrobial resistance. While everybody's skin is populated with a mixture of healthy and harmful bacteria, the ratio of good to bad isn't always the same. This imbalance could help to explain why some people have conditions like atopic dermatitis (AD) the most common form of eczema, which produces inflamed and irritated skin, and affects almost 18 million Americans. "People with this type of eczema, for some reason that's not quite known yet, have a lot of bacteria on the skin, but it's the wrong type of bacteria," dermatologist Richard Gallo from UC San Diego told the Associated Press. "They're not producing the antimicrobials they need." To find out about the makeup of these bacteria populations, Gallo and his team examined skin culture swabs taken from 30 healthy people and 49 subjects with AD. After screening thousands of colonies of bacteria, … Continue reading

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Women’s stress levels before pregnancy could influence risk of eczema in their future children – Medical Xpress

Posted: Published on March 1st, 2017

February 28, 2017 Womens stress levels before pregnancy could influence risk of eczema in child. Credit: University of Southampton Infants whose mothers who felt stressed before they fell pregnant had a higher risk of eczema at age 12 months, new Southampton research has shown. The study from the Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, is the first to link preconception maternal stress to the risk of atopic eczema in the child. The researchers believe the findings support the concept that eczema partly originates as a baby develops in the womb and could reveal ways of reducing the risk of the skin condition. The research, published in Clinical and Experimental Allergy, assessed the stress levels of women recruited to the Southampton Women's Survey before they were pregnant. They were asked to report how stressed they were in their daily lives. A sub-group were asked about their psychological wellbeing. Around 3,000 babies born into the Survey were then assessed for eczema at ages six and 12 months. Dr Sarah El-Heis, the study's lead researcher from the University of Southampton, comments: "We know that maternal stress can release certain hormones that can have an effect on the baby's immune response, … Continue reading

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Eczema-taming ointment could be made with bacteria from your own skin – Genetic Literacy Project

Posted: Published on March 1st, 2017

Teruaki Nakatsuji and Richard Gallo from the University of California, San Diego, have discovered that some bacteria which naturally live on human skin produce chemicals that kill S. aureus[a bacterium that can cause severe skin infections]. [The duo then] went after the bacteria themselvesisolating them from people with a skin disease called atopic dermatitis (eczema), growing them, and adding them to a cream. The result: a personalized ointment for killing S. aureusand hopefully treating eczemausing bacteria that come from a persons own skin. The team focused on one [type of bacterium]a strain of S. hominis called A9Strain A9 produces several new antibiotics that seem to specifically suppress the growth of S. aureus, including the drug-resistant versions that we know as MRSA. Protective staph strains like A9 dominate the skins of healthy people, buteven in people with eczema, the protective strains arent totally absent. Theyre still there. So what happens if you give them a boost? As expected, the levels of S. aureus fell by more than 90 percent. In two cases, the troublesome microbe disappeared entirely. Its a big step towards using microbial therapies to treat skin disease, says Shruti Naik, from Rockerfeller University. The GLP aggregated and excerpted this … Continue reading

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Eteplirsen in the treatment of Duchenne muscular dystrophy – Dove Medical Press

Posted: Published on March 1st, 2017

Back to Browse Journals Drug Design, Development and Therapy Volume11 Kenji Rowel Q Lim,1 Rika Maruyama,1 Toshifumi Yokota1,2 1Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, 2The Friends of Garrett Cumming Research & Muscular Dystrophy Canada, HM Toupin Neurological Science Research Chair, Edmonton, AB, Canada Abstract: Duchenne muscular dystrophy is a fatal neuromuscular disorder affecting around one in 3,5005,000 male births that is characterized by progressive muscular deterioration. It is inherited in an X-linked recessive fashion and is caused by loss-of-function mutations in the DMD gene coding for dystrophin, a cytoskeletal protein that stabilizes the plasma membrane of muscle fibers. In September 2016, the US Food and Drug Administration granted accelerated approval for eteplirsen (or Exondys 51), a drug that acts to promote dystrophin production by restoring the translational reading frame of DMD through specific skipping of exon 51 in defective gene variants. Eteplirsen is applicable for approximately 14% of patients with DMD mutations. This article extensively reviews and discusses the available information on eteplirsen to date, focusing on pharmacological, efficacy, safety, and tolerability data from preclinical and clinical trials. Issues faced by eteplirsen, particularly those relating to its efficacy, will be identified. Finally, the place … Continue reading

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