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UW biotech spinout DMD Therapeutics raises $400k to pursue … – GeekWire

Posted: Published on March 1st, 2017

Ronald Berenson, serial entrepreneur, is heading up DMD Therapeutics. (CoMotion Photo / Conrado Tapado) DMD Therapeutics, abiotechstartup that was spun out of the University of Washington by biotech entrepreneur Ron Berenson last year, is emerging from stealth mode. The startup announced that it raised a $400,000 seed fund round to pursue a possible treatment forDuchenne muscular dystrophy (DMD), a rare and severe form of muscular dystrophy. The funds come from three foundations dedicated to funding research for DMD treatments:Ryans Quest, Michaels Cause, and Pietros Fight. Inan SEC filing from last year, the company indicated it plans to raise $600,000 in initial funding. According to a news release, DMD Therapeutics first drug candidate was successful in preclinical trials in mice and will now move forward into human trials. The funds will fuel initialresearch and development efforts along with early manufacturing steps. Duchenne is a genetic disease that primarily affects boys. It causes muscles to become increasingly weak, meaning many who are affected lose the ability to walk and perform motor skills at a young age. This weakening of muscles eventually leads to death. Although there are some treatments that can limit symptoms of DMD, there are currently no treatments that targetthe … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on UW biotech spinout DMD Therapeutics raises $400k to pursue … – GeekWire

Grant to help look for a cure for Duchenne Muscular Dystrophy – The Charlottesville Newsplex

Posted: Published on March 1st, 2017

CHARLOTTESVILLE, Va. (NEWSPLEX) -- Researchers are getting millions of dollars to try and find a cure for a type of Muscular Dystrophy that usually kills young men by the time they reach their mid-20s. According to a release, Duchenne Muscular Dystrophy affects one in 3,500 boys, taking their ability to walk by the age of 12 and typically killing them in their mid-20s. While doctors do know what causes the disease, potential treatments for it have consistently failed. Now University of Virginia researchers will be looking to change that will the help of a $2.5 million grant from the National Institutes of Health. Members of the UVA School of Medicine and the School of Engineering and Applied Science will use the money to build a computer model of the disease to look at what may have undermined efforts to develop an effective treatment. Duchenne is caused by the lack of a particular cellular protein, called dystrophin, and researchers think the problems with treatments could be caused by differences in biomechanics and inflammation between lab mice and children. With the model, researchers will look to better understand how muscle damage and inflammation drive the disease, understand the relationship between movement and … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on Grant to help look for a cure for Duchenne Muscular Dystrophy – The Charlottesville Newsplex

Using a Mini-Scaffold to Help Treat Spinal Cord Injury – Bioscience Technology

Posted: Published on March 1st, 2017

Patients suffering from complete spinal cord injuries have little to no treatment options that provide meaningful improvement in patient outcomes. Cambridge, Mass.-based InVivo Therapeutics is trying to change that. Co-founded in 2005 by MIT professor Robert Langer, and surgeon-scientists Joseph Vacanti, M.D., the company has developed a small, bioresorbable and biocompatible device called the Neuro-Spinal Scaffold, to help patients with complete thoracic spinal cord injuries regain some function. The highly porous device, smaller than the size of a quarter, is made up of Poly(lactic-co-glycolic acid) [PLGA], the same material as absorbable sutures, and two percent Ply-L-Lysine [PLL], which acts as a cellular adhesive, CEO Mark Perrin told Bioscience Technology during an interview at the BIO CEO and Investor Conference in New York City in February. The polymer scaffold eventually degrades over several weeks. A clinical trial involving 20 patients is currently underway, and initial results have been promising. Perrin explained that when spinal cord injury happens, there is tremendous force against the spine, which then pushes up against the cord and hemorrhaging and swelling begins inside the cord. Then a necrotic process, or premature cell death, takes places. Inside the spinal cord there is a butterfly shape made up of … Continue reading →

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Treatment of stress urinary incontinence in men with spinal cord injury: minimally invasive=minimally effective? – UroToday

Posted: Published on March 1st, 2017

Retrospective chart review. To assess the outcome of minimally invasive treatment of stress urinary incontinence with alloplastic slings in patients with neurogenic lower urinary tract dysfunction. Switzerland. The patient database of a tertiary urologic referral center was screened for male patients with SCI who underwent implantation of a suburethral sling between June 2009 and December 2015. Patient characteristics and bladder management details were collected by chart review. Sixteen patients were identified. Of those, 13 received a transobturator tape (TOT) and three underwent implantation of an retropubic adjustable system (RAS). In the TOT group, nine patients became continent, one patient was improved and three patients remained unchanged. Three patients underwent minor revisions due to impaired wound healing. In the RAS group, no patient improved and one RAS had to be removed due to severe wound infection; in a second patient, an abscess with destruction of the urethra occurred. In our experience, alloplastic slings seem to be an effective minimally invasive treatment option in male patients with SUI due to SCI. TOT seem to be more effective than RAS and was associated with less severe complications. The selection criteria for the optimal patient and the optimal sling have to be further defined.Spinal … Continue reading →

Posted in Spinal Cord Injury Treatment | Comments Off on Treatment of stress urinary incontinence in men with spinal cord injury: minimally invasive=minimally effective? – UroToday

InVivo Therapeutics to Present and Exhibit at Spine Summit 2017 | – OrthoSpineNews

Posted: Published on March 1st, 2017

CAMBRIDGE, Mass.(BUSINESS WIRE)InVivo Therapeutics Holdings Corp. (NVIV)today announced that two INSPIRE study Principal Investigators, Dom Coric, M.D. and Michael Fehlings, M.D., Ph.D., will be giving oral presentations at the Spine Summit 2017 to be held March 8-11, 2017 in Las Vegas, NV. Dr. Coric will present INSPIRE Study Update on 10 Subjects Implanted with a Bioresorbable Polymer Scaffold Following Acute Complete Thoracic Spinal Cord Injury, and Dr. Fehlings will present Magnetic Resonance Imaging (MRI) Does Not Distinguish between Contusion and Compound Cord Lesions Following Severe (AIS A) Traumatic Acute Thoracic Cord Injury: Intraoperative Microsurgical Observations from the INSPIRE Trial during the Peripheral Nerve, Basic Science Breakout session on Saturday, March 11. Dr. Fehlings will also present during a Whats New Session on Friday, March 10. The session will include discussion of the Neuro-Spinal Scaffoldtechnology and INSPIRE study and will continue to raise awareness amongst leading spine neurosurgeons. Mark Perrin, Chairman and CEO, said, The Spine Summit affords us the opportunity to build mindshare within the most pertinent group of surgeons for the Neuro-Spinal Scaffold. This meeting has proven to be one of the most fruitful in terms of bringing on board new INSPIRE sites, and we look forward to having … Continue reading →

Posted in Spinal Cord Injury Treatment | Comments Off on InVivo Therapeutics to Present and Exhibit at Spine Summit 2017 | – OrthoSpineNews

Auckland research reveals for first time how Parkinson’s develops – Auckland stuff.co.nz

Posted: Published on March 1st, 2017

NICOLE LAWTON Last updated00:04, February 24 2017 Health Canada The breakthrough in the understanding of how Parkinson's spreads through the brain will lead to better treatment options for sufferers of the disease. A breakthroughdiscovery in Parkinson's research has shed light about how the disease spreads through the brain. The University of Auckland research has debunked traditional thinking about the disease and revealed newpotential treatment strategies. The study, which was published inScientific Reports Natureon Thursday, will bring "real hope" to the13,000 New Zealanders living with the disease, according to Parkinson's New Zealand. Supplied Parkinson's New Zealand chief executive Deirdre O'Sullivan called the study "world-leading" research. "For many years we've been talking about finding a cause, cure or prevention of Parkinson's and this is something that would really help us take a big step towards that goal," said DeirdreO'Sullivan,chief executive ofParkinson's New Zealand. READ MORE: *Living with someone who has Parkinson's disease is a struggle *'I have Parkinson's at 32' * Battling Parkinson's disease with exercise It's thefirst proof, in cell culture, ofhow pathological proteins calledLewybodiesspread from cell to cell in the brain of a person affected byParkinson's, said associate professorMaurice Curtis. Supplied Parkinson's sufferer Judy Clarke said it is encouraging to … Continue reading →

Posted in Parkinson's Treatment | Comments Off on Auckland research reveals for first time how Parkinson’s develops – Auckland stuff.co.nz

Parkinson’s Disease drugs linked to risk of compulsive gambling, shopping and binge eating, study shows – Knowridge Science Report

Posted: Published on March 1st, 2017

Drugs commonly prescribed to treat Parkinsons disease have been linked to impulse control disorders such as pathological gambling, compulsive buying, hypersexuality and binge eating in some patients This is reported in a review conducted by neurologists at Loyola Medicine and Loyola University Chicago Stritch School of Medicine. These disorders can have disastrous personal, professional and financial consequences if not recognized or treated, according to the article in the journal Expert Review of Neurotherapeutics. Authors of the paper include Jos Biller, MD, and first author Adolfo Ramirez-Zamora, MD, who completed a residency in neurology at Loyola. The paper details the latest findings for treating impulse control disorders (ICDs) in Parkinsons disease patients, including adjusting medications, deep brain stimulation and a counseling technique called cognitive behavioral therapy. One large, previous national study found that approximately 14 percent of Parkinsons disease patients experience at least one ICD. The disorders are more common in men. Men are more likely to display hypersexuality and pathological gambling, while women are more likely to exhibit compulsive eating and buying. Potentially catastrophic consequences include financial ruin, divorce and loss of employment. Patients often lack insight and underestimate the presence and severity of ICDs and related conditions, the authors … Continue reading →

Posted in Parkinson's Treatment | Comments Off on Parkinson’s Disease drugs linked to risk of compulsive gambling, shopping and binge eating, study shows – Knowridge Science Report

Is Botox realistic? – News-Press Now

Posted: Published on March 1st, 2017

Botox, a neurotoxin used for years to help soften fine lines and wrinkles, is now being used to help migraine headache sufferers and stroke and cerebral palsy patients. It relaxes the muscles and interferes with neurofibers, preventing them from being stimulated, explains Dr. Debra Keith, a physician and owner of Weston Family Clinic and Medical Spa. In 2010, the Food and Drug Administration approved Botox as a treatment for migraines. Botox also hasoffered relief to people suffering from excessive perspiration. Dr. Keith is a trained injector of the drug for both migraine treatment and cosmetic use. To help reduce a patients migraines, 31 sites around the head are injected with Botox significantly more than the number of sites used to relax facial wrinkles, Dr. Keith says. The injections take approximately seven to 10 minutes to complete. The statistics tell us that people start seeing the benefits in about three months, she says. Initially, neurologists were the first providers to offer the therapeutic migraine treatment, but this meant long waits for patients to get relief, Dr. Keith explains. Now, many more family-practice physicians are receiving the training to inject Botox for migraine sufferers. Dr. Keith has a patient with severe migraines … Continue reading →

Posted in Cerebral Palsy Treatment | Comments Off on Is Botox realistic? – News-Press Now

Children with severe epilepsy chosen as first patients to legally receive medicinal cannabis in Victoria – ABC Online

Posted: Published on March 1st, 2017

Updated March 01, 2017 15:11:30 A group of 29 critically ill children have been chosen as the first patients to legally access medicinal cannabis in Victoria. The Andrews Government purchased the cannabidiol liquid from Canada after changes to federal laws last year. The children all have severe intractable epilepsy and have multiple daily seizures. Victorian Health Minister Jill Hennessy said the children were nominated by paediatric neurologists to receive the treatment and then assessed by a clinical panel. "We know this medicine can dramatically change the quality of life for some of Victoria's very sick kids," she said. "This means families will no longer have to make the heartbreaking choice between breaking the law or watching their kids suffer." Ms Hennessy said the cost to the Government over a 12-month period would be about $1 million. "We know this medicine can dramatically change the quality of life for some of Victoria's very sick kids," she said. "This means families will no longer have to make the heart-breaking choice between breaking the law or watching their kids suffer." Melbourne mother Ally Tregent said her five-year-old daughter Gemma, who has cerebral palsy and epilepsy, began the treatment last week. "The last year … Continue reading →

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Glasgow kid, 9, had brain damage from drinking booze (From … – Glasgow Evening Times

Posted: Published on March 1st, 2017

CHILDREN as young as nine-years-old are being treated for alcohol-related brain damage in Glasgow, the Evening Times can reveal. Along with dozens of children, thousands more adults have also received help from NHS Greater Glasgow and Clyde (NHSGGC) in the past six years. They have been admitted to hospital for mental and behaviour problems relating to alcohol addiction and, including psychotic disorders, withdrawal, delirium, harmful use of alcohol and alcohol dependence. It comes as alcohol campaigners have called for booze adverts to be banned before 11pm, and magazine and newspapers adverts for drinks to be restricted. In total since January 2011, more than 17,000 people, including 163 children, have been treated for some form of alcohol-related brain damage. Figures obtained by the Evening Times show a nine-year-old boy was the youngest person to be treated for a mental or behaviour disorder due to drinking alcohol by NHSGGC. The youngster was first seen by doctors in 2012. There have also been 69 girls and 93 boys, ranging from 13 to 17-years-old, who received treatment since 2011. Of the 17,224 adults suffering from some type of alcohol-related brain damage, the largest group (around 7400 people) were between 45 and 64 years old. … Continue reading →

Posted in Brain Injury Treatment | Comments Off on Glasgow kid, 9, had brain damage from drinking booze (From … – Glasgow Evening Times

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