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Innovate Biopharmaceuticals, Targeting Celiac Disease And Ulcerative Colitis, presenting at BIO CEO & Investor … – PR Newswire (press release)

Posted: Published on February 9th, 2017

Innovate is a privately held, clinical stage biotechnology company focused on developing novel autoimmune/inflammation medicines.Innovate is also developing therapeutics for unmet needs with global impact and for orphan indications. The company's lead drug candidate for celiac disease, larazotide acetate (INN-202), begins Phase 3 clinical trials in 2017. Larazotide, a novel oral peptide, has been studied in more than 800 patients with results that consistently reduced clinical symptoms of celiac disease. Larazotide's unique mechanism of action of reducing antigen trafficking across epithelial cells makes it a promising therapeutic for multiple diseases involving "leaky tight junctions." Innovate's second therapeutic, INN-108, enters Phase 2 trials in 2017. INN-108 is a small molecule for the treatment of an adult orphan indication and for mild to moderate ulcerative colitis. INN-108 is a prodrug that only becomes activated in the colon. An oral liquid formulation is also in development for pediatric and elderly patients. Licensing opportunities for these drugs are available outside the U.S. Forward Looking Statements This press release contains forward-looking statements, including statements regarding the clinical development of our product candidates, which are subject to risks and uncertainties that could cause actual results to differ materially. Reported results should not be considered as an … Continue reading →

Posted in Ulcerative Colitis | Comments Off on Innovate Biopharmaceuticals, Targeting Celiac Disease And Ulcerative Colitis, presenting at BIO CEO & Investor … – PR Newswire (press release)

John Ryan on his ulcerative colitis: ‘It is no way to live’ | Irish Examiner – Irish Examiner

Posted: Published on February 9th, 2017

He may not have got the chance to do what he loves most and scrummaged against the Scots last week but just being on the pitch at Murrayfield making his Six Nations debut was a dream come true for John Ryan given the journey he has taken of late. Eleven minutes off the bench for Tadhg Furlong, the Munster tighthead prop got the chance to build on a Test debut against Canada last November and although neither he nor replacement loosehead Cian Healy got to pack down against an under-pressure Scottish scrum, the frustration was alleviated by the knowledge he had taken another huge step in his development from provincial squad man to international. That Ryan, 28, from Berrings, Cork, has progressed at the rate he has in the past 18 months being cited by Alan Quinlan recently as the most improved player in Ireland this season - has been even more impressive given for the last few years he has been forced to cope with an inflammatory intestinal condition known as ulcerative colitis that caused him to rapidly lose 10 kilograms in 2014 to drop from 118kgs (19 stone) to 108kg. Initially having to adopt a gluten-free diet, Ryan … Continue reading →

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Commentary: Insurers make troubling decisions on new treatments – Philly.com

Posted: Published on February 9th, 2017

By Brian Kennedy When the U.S. Food and Drug Administration approved a revolutionary medication for Duchenne muscular dystrophy in September, it marked a historic milestone for thousands of families with no treatment options for their loved ones. Developing new treatments for rare diseases can be a challenging process - oftentimes, it results in failure. The celebration has been short lived for some patients, families, and health-care providers. A number of health insurers are creatively denying treatment coverage for the 1,200 to 1,500 boys in the United States whose genetic mutation makes them eligible for the medication. In some cases, insurers are calling this breakthrough treatment "investigational." In reality, FDA's approval process holds drugs to rigorous safety and efficacy standards. In other instances, insurers are first demanding extraordinary measures such as biopsies, which take away critical muscle mass and require already vulnerable patients to undergo anesthesia in an inpatient hospital setting. Unfortunately, these coverage decisions mark a troubling sign of things to come. As precision medicine becomes the new normal, insurers will undoubtedly encounter many more high-cost, high-value treatments. Some will face an acceptable level of uncertainty at the time of approval. Most all will offer direct benefit, albeit for a … Continue reading →

Posted in Muscular Dystrophy Treatment | Comments Off on Commentary: Insurers make troubling decisions on new treatments – Philly.com

Blood test might make Parkinson’s diagnosis easier, study says – fox8.com

Posted: Published on February 9th, 2017

(Photo credit MARION BERARD/AFP/GettyImages) (Photo credit MARION BERARD/AFP/GettyImages) A new blood test may be as accurate as a test requiring a painful spinal tap for differentiating Parkinsons disease from similar disorders, according to a study published Wednesday in Neurology, the medical journal of the American Academy of Neurology. Parkinsons disease is a neurological disorder that can cause tremors, stiffness, slowness of movement, trouble balancing, problems walking and difficulty coordinating movement. Less obvious symptoms include depression, insomnia, anxiety, fatigue and constipation. Neurological disorders that mimic the symptoms of Parkinsons disease are called atypical parkinsonism disorders. Many doctors cannot tell whether a patient has Parkinsons disease or atypical parkinsonism. This can be very challenging, especially during the early stages of the diseases and if the responsible doctor is not a neurologist specialized in movement disorders, said Dr. Oskar Hansson, lead author of the new study, a neurologist and an associate professor at Lund University in Sweden. Non-specialists do not really know exactly what questions to ask the patient and the special signs to look for, Hansson wrote in an email. Yet patients with atypical disorders usually have a much worse prognosis, with faster disease progression, (with) more disabling symptoms than Parkinsons patients, … Continue reading →

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Everett man allegedly admits abusing boy who has cerebral palsy … – The Daily Herald

Posted: Published on February 9th, 2017

You must sign in or register to continue reading content. MARYSVILLE An Everett man was jailed Friday for investigation of felony assault after he allegedly admitted biting and otherwise abusing a young boy who has cerebral palsy. The suspect, 31, had been spending time with the childs mother the last couple of months. Marysville police began investigating after the boy, who turns 4 in July, was taken to an area hospital for treatment of a broken ankle. Hospital workers found three fractures to the boys lower left leg. He also had bruises to his face, chest and on his ear, according to a police report filed in connection with the arrest. A doctor trained to recognize signs of abuse told police the bruises were clearly non-accidental and that the broken bones may have been the result of the boys leg having been stomped, but she could not say for certain. The childs mother first took the boy to the hospital Jan. 28 after he complained of pain in his leg. No fractures were found. She returned with him the next day after it appeared his condition had worsened. The night before, she heard the boy crying. The suspect told her … Continue reading →

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Traumatic Brain Injury – familydoctor.org

Posted: Published on February 9th, 2017

Treatment How is a traumatic brain injury treated? Treatment for a traumatic brain injury depends on the severity of the injury. If you have a mild traumatic brain injury, over-the-counter pain medicine can help with headaches and neck pain. Treatment for a moderate or severe traumatic brain injury depends on the symptom. If you are having seizures, you may be given medicine to reduce the number of seizures. If you have certain kinds of arm spasticity, you may be able to try an injection of botulinum toxin into the muscle to help stop muscle spasms. You may need surgery if there is a skull fracture, if there are blood clots that need to be removed from the brain or if there is too much pressure inside the skull. If the traumatic brain injury is severe, you may need physical and occupational therapy to regain skills that you may have forgotten because of your brain injury. Some of these skills can include walking, talking and feeding yourself. Physical therapy is made up of stretching, strengthening exercises and muscle training. It helps with flexibility, coordination and strength. Occupational therapy can help you re-learn how to perform daily tasks, such as bathing, getting … Continue reading →

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Designer compound may untangle damage leading to some dementias – Science Daily

Posted: Published on February 9th, 2017

Science Daily Designer compound may untangle damage leading to some dementias Science Daily Currently there are no effective treatments for combating toxic tau. "This compound may literally help untangle the brain damage caused by tau," said Timothy Miller, M.D., Ph.D., the David Clayson Professor of Neurology at Washington University, St ... and more » More here: Designer compound may untangle damage leading to some dementias - Science Daily … Continue reading →

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Anti-cell death agent a potential treatment for vision loss associated with MS – Science Daily

Posted: Published on February 9th, 2017

Science Daily Anti-cell death agent a potential treatment for vision loss associated with MS Science Daily The team demonstrated the therapeutic potential of the agent, called ST266, for treating optic neuritis, inflammation that damages the optic nerve and is a common presenting feature of MS. About half of patients diagnosed with MS experience optic ... and more » View post: Anti-cell death agent a potential treatment for vision loss associated with MS - Science Daily … Continue reading →

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Testosterone Replacement Therapy Market (2016-2021) – Globally … – PR Newswire (press release)

Posted: Published on February 9th, 2017

Testosterone replacement therapy (TRT), also known as Androgen replacement therapy (ART), is a class of hormone replacement therapy in which androgens, often testosterone, are replaced to treat conditions in which the testes do not produce enough testosterone due to absence, injury, or disease. Testosterone deficiency amongst men above the age of 30 years is becoming a common problem nowadays due to life style changes and is characterized by fewer erections, fatigue, thinning skin, declining muscle mass and strength, more body fat. Globally increasing population with testosterone deficiency is expected to remain key growth driver during the period of study. However, side effects of the testosterone replacement therapies are expected to be a key challenge for the industry players during the same time. Geographically, North America dominates the testosterone replacement therapy market driven by best in class infrastructure, easy access to healthcare, higher awareness about the disease amongst citizens as well as practitioners, and higher spending by the citizens towards healthcare expenditure. North America was followed by Europe and Asia-Pacific as second and third largest markets for testosterone replacement therapy market. Asia Pacific is projected to have the fastest growth, owing to rapidly developing medical infrastructure, increasing medical tourism, increased spending, … Continue reading →

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BHRT: A match made in anti-aging – ModernMedicine

Posted: Published on February 9th, 2017

Dr. LightCosmetic surgery and hormone replacement address the same issue from different vantage points. As such, bioidentical hormone replacement therapy, or BHRT, is a powerful tool that should be incorporated into all successful cosmetic practices, according to Kevin Light, DO, MBA, a cosmetic surgeon and age management specialist in Dallas, Texas. Dr. Light presented Bioidentical Hormone Replacement Therapy and the Cosmetic Surgery Practice yesterday at the American Academy of Cosmetic Surgerys (AACSs) 2017 annual scientific meeting in San Diego, Calif. Dr. Light, author of the book OutSmart Aging, tells Cosmetic Surgery Times that, from a cosmetic perspective, aging negatively impacts the skin, with thinning, wrinkling, age spots and pigmentation, as well as loss of elasticity, resiliency and glow. Cosmetic aging results in soft tissue volume loss, in the face, breast and abdomen. It also results in bone loss, or shrinkage of the skull and mandible; hair loss, weight gain and fat redistribution. Hormone loss causes impaired wound healing and immune function, which can impact cosmetic surgery patients. Hormone loss also results in quality of life issues, from energy and sleep, to concentration, memory, libido and sexual function, he says. BHRT can halt or reverse all of this. This is no … Continue reading →

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