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Ulcerative Colitis : Practice Essentials, Background, Anatomy

Posted: Published on December 13th, 2016

Murata I, Satoh K, Yoshikawa I, Masumoto A, Sasaki E, Otsuki M. Recurrent subcutaneous abscess of the sternal region in ulcerative colitis. Am J Gastroenterol. 1999 Mar. 94(3):844-5. [Medline]. Kimura K, Hunter SF, Thollander MS, Loftus EV Jr, Melton LJ 3rd, O'Brien PC, et al. Concurrence of inflammatory bowel disease and multiple sclerosis. Mayo Clin Proc. 2000 Aug. 75(8):802-6. [Medline]. Egan CA, Meadows KP, Zone JJ. Ulcerative colitis and immunobullous disease cured by colectomy. Arch Dermatol. 1999 Feb. 135(2):214-5. [Medline]. Esteve M, Gisbert JP. Severe ulcerative colitis: at what point should we define resistance to steroids?. World J Gastroenterol. 2008 Sep 28. 14(36):5504-7. [Medline]. [Full Text]. Shen B. Crohn's disease of the ileal pouch: reality, diagnosis, and management. Inflamm Bowel Dis. 2009 Feb. 15(2):284-94. [Medline]. Van Assche G, Vermeire S, Rutgeerts P. Treatment of severe steroid refractory ulcerative colitis. World J Gastroenterol. 2008 Sep 28. 14(36):5508-11. [Medline]. [Full Text]. Heuschen UA, Hinz U, Allemeyer EH, Stern J, Lucas M, Autschbach F. Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology. 2001 Mar. 120(4):841-7. [Medline]. Kaufman SS, Vanderhoof JA, Young R, Perry D, Raynor SC, Mack DR. Gastroenteric inflammation in children with ulcerative colitis. Am J Gastroenterol. 1997 … Continue reading →

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CCFA: Colitis Diagnosis | Ulcerative Colitis Tests

Posted: Published on December 13th, 2016

Your doctor will make a diagnosis based on your medical history, a physical examination, and a series of tests. The first goal of these tests is to differentiate ulcerative colitis from infectious causes of diarrhea. Following this, the patient generally undergoes an evaluation of the colon, using one of two tests -- a sigmoidoscopy or total colonoscopy. In addition to making the initial diagnosis, the tests your doctor performs will also help determine which type of Ulcerative Colitis you have. Each type has its own specific symptoms and associated complications. Learn more about the different Types of Colitis. Your doctor will conduct a physical exam of your body and interview you to learn more about your general health, diet, family history, and environment. Early steps in the diagnostic process can include laboratory tests of blood and fecal matter. Stool specimens are analyzed to eliminate the possibility of bacterial, viral, or parasitic causes of diarrhea. Blood tests can check for signs of infection as well as for anemia, which may indicate bleeding in the colon or rectum. Your doctor may recommend endoscopy, which is the use of medical instruments to visually examine the interior of your colon with a lighted tube … Continue reading →

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Induced pluripotent stem cell – Wikipedia

Posted: Published on December 13th, 2016

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from adult cells. The iPSC technology was pioneered by Shinya Yamanakas lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes encoding transcription factors could convert adult cells into pluripotent stem cells.[1] He was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent." [2] Pluripotent stem cells hold great promise in the field of regenerative medicine. Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. The most well-known type of pluripotent stem cell is the embryonic stem cell. However, since the generation of embryonic stem cells involves destruction (or at least manipulation) [3] of the pre-implantation stage embryo, there has been much controversy surrounding their use. Further, because embryonic stem cells can only be derived from embryos, it has so far not been … Continue reading →

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Why Is There Mucus In My Stools – Ulcerative Colitis

Posted: Published on December 12th, 2016

Mucus In My Stools: What can be more annoying than looking into the toilet when you are in the middle of ulcerative colitis symptoms and seeing something that is unfamiliar? mucus on a stool in the toilet bowl How often should people be examining their stools or poops if you want to call them that anyways? It seems that for everyone with ulcerative colitis, what ends up in the toilet bowl is almost the most exciting or sometimes depressing part of the day. How strange is that. Yet again, I threw myself back into denial, and just avoided thinking about what this strange slimmy mucus stuff was. I had no idea why it was attached to almost every crap that landed in the toilet bowel, and I really was worried that something was wrong inside of me. Mucus is simply a secretion that comes from many different parts of the body. It is not limited to the intestines, but rather it can be found on the inner lining walls of the stomach as well as other organs of the body. It is not something to be worried about most of the time. The job of mucus is to protect and … Continue reading →

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CCFA: Find Studies and Clinical Trials – Colitis | IBD

Posted: Published on December 12th, 2016

Deciding whether you should participate in a study or clinical trial is an important personal decision. Your decision is best made with a full understanding of the process of drug development and your specific role. While the choice is ultimately yours, we also highly recommend that you first discuss it with your physician, as well as members of your family and friends. Learn more about our clinical trials and how you can get involved. The Crohn's & Colitis Foundation of Americas (CCFA) also maintains a comprehensive database of studies, clinical trials, and other research into Crohn's Disease and Ulcerative Colitis. You can use the search tool below to access listings for current and upcoming opportunities to participate in this research. Search by keyword, or specify which disease you have been diagnosed with, as well as your location, to help narrow your search. 635839175|*|40.1167446|*|-88.21448570000001|*|611 West Park Street, Urbana, IL 61801, USA|*|Urbana|*|61801|*|IL|*| A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance Therapy in Subjects with Moderately to Severely Active Ulcerative Colitis|*|,ulcerative-colitis|*|,adult-18|*|,female,male|*|,moderate,severe|*|,clinical-trials|*|http://www.ccfa.org/research/participate-in-research/find-studies-and-clinical-trials/serene/a-double-blind-randomized-24.html|*||*|,IL625402831|*|37.1470853|*|-80.4138595|*|110 Akers Farm Road Northeast, Christiansburg, VA 24073, USA|*|Christiansburg|*|24073|*|VA|*| A Double-Blind, Randomized, Multicenter Study of Higher Versus Standard Adalimumab Dosing Regimens for Induction and Maintenance … Continue reading →

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Could gene therapy become biotechs growth driver in 2017 …

Posted: Published on December 8th, 2016

Despite bouncing off a 2-year low, biotech is still an unpopular sector and investors are rightfully concerned about its near-term prospects. Recent drug failures, growing pricing pressure and the potential impact of biosimilars all contribute to the negative sentiment, but the main problem is the lack of growth drivers for the remainder of 2016 (and potentially 2017). The biotech industry relies on innovation cycles to create new revenue sources. This was the case in the 2013-2014 biotech bull market, which was driven by a wave of medical breakthroughs (PD-1, HCV, CAR/TCR, oral MS drugs, CF etc.). These waves typically involve new therapeutic approaches coupled with disruptive technologies as their enablers. In oncology, for example, the understanding that cancer is driven by aberrant signaling coupled with advances in medicinal chemistry and antibody engineering led to the development of kinase inhibitors and monoclonal antibodies as blockers of signaling. A decade later, insights around cancer immunology gave rise to the immuno-oncology field and PD-1 inhibitors in particular, which are expected to become the biggest oncology franchise ever. Gene therapy ticks all the boxes While there are several hot areas in biotech such as gene editing and microbiome, most are still early and their … Continue reading →

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12 Spinal Cord Injury Nursing Care Plans – Nurseslabs

Posted: Published on December 7th, 2016

Discuss injury process, current prognosis, and future expectations. Provide common knowledge base necessary for making informed choices and commitment to the therapeutic regimen.Note: Improvement in managing effects of SCI has increased life expectancy of patients to only about 5 yr below norm for specific age group. Provide information and demonstrate: Positioning Promotes circulation; reduces tissue pressure and risk of complications. Use of pillows, supports, splints Keeps spine aligned and prevents or limits contractures, thus improving function and independence. Encourage continued participation in daily exercise and conditioning program and avoidance of fatigue and chills. Reduces spasticity, risk of thromboembolic (common complication). Increases mobility, muscle strength and tone for improving organ and body functionsuch assqueezing rubber ball, arm exercises enhance upper body strength to increase independence in transfers or wheelchair mobility; tightening or contracting rectum or vaginal muscles improves bladder control; pushing abdomen up, bearing down, contracting abdomen strengthens trunk and improves GI function (paraplegic). Identify energy conservation techniques and stress importance of pacing activities and adequate rest. Review drug regimen note use of baclofen (Lioresal), diazepam (Valium), tizanidine (Zanaflex). Fatigue is common and limits patients ability to participate in and manage care, decreasing quality of life and increasing feelings of helplessness … Continue reading →

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Cervical Spine Chapter – Spinal Nerves Surgery Fairfax

Posted: Published on December 7th, 2016

Normal Anatomy There are 33 bones that make up the spinal column. There are 7 bones in the neck (cervical spine), 12 in the trunk (thoracic spine), 5 in the low back (lumbar spine), 5 fused bones that attach the spine to the pelvis (sacrum) and 3 fused bones form the tail bone (coccyx). The cervical spine three two main functions: The spinal cord is attached to the brain and is similar to a large electrical cable. It conducts information between the brain and the arms and legs. Approximately 60 smaller nerves exit the spinal cord (30 to the right and 30 to the left) along its path from top (base of the brain) to bottom (the spinal cord generally ends at the disc between the first and second lumbar vertebrae). Each nerve exits from a hole that is formed where two vertebrae meet (called the neural foramen) and is thus named (eg the nerve that exits adjacent to the 5th cervical bone is called the C5 nerve root). These nerve roots go to different parts of the body (arms, trunk, legs, bowel and bladder) and transmit information to and from those regions (eg the C5 nerve root carries sensation … Continue reading →

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Hydrocephalus – Wikipedia

Posted: Published on December 7th, 2016

Hydrocephalus is a condition in which there is an abnormal accumulation of cerebrospinal fluid (CSF) within the brain.[1] This typically causes increased pressure inside the skull. Older people may have headaches, double vision, poor balance, urinary incontinence, personality changes, or mental impairment. In babies there may be a rapid increase in head size. Other symptoms may include vomiting, sleepiness, seizures, and downward pointing of the eyes.[1] Hydrocephalus can occur due to birth defects or be acquired later in life.[1] Associated birth defects include neural tube defects and those that result in aqueductal stenosis.[1][2] Other causes include meningitis, brain tumors, traumatic brain injury, intraventricular hemorrhage, and subarachnoid hemorrhage. There are four types of hydrocephalus: communicating, non-communicating, ex-vacuo, and normal pressure. Diagnosis is typically by examination and medical imaging.[1] Hydrocephalus is typically treated by the surgical placement of a shunt system. A procedure called a third ventriculostomy may be an option in a few people. Complications from shunts may include overdrainage, underdrainage, mechanical failure, infection, or obstruction. This may require replacement. Outcomes are variable; however, many live normal lives. Without treatment death may occur.[1] About one to two per 1,000 newborns have hydrocephalus.[1][3] Rates in the developing world may be more.[4] Normal … Continue reading →

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Worlds Leading Genomics Conference | Global Meetings …

Posted: Published on December 7th, 2016

Sessions/Tracks ConferenceSeries LLC provides the perfect platform for global networking and we are truly delighted to invite you to attend our 9thInternational Conference on Genomics & Pharmacogenomics, during June 15-16, 2017London, UK. Genomics-2017 is a global platform to discuss and learn about Genomics & Pharmacogenomics and its allied areas Bioinformatics, Transcriptomics, Biotechnology, Molecular Biology, Molecular Genetics and Genetic Engineering. Track 1:Cancer Genomics TumorGenomicsis the investigation ofhereditarytransformationsin charge of malignancy, utilizinggenomesequencingandbioinformatics. Diseasegenomicsis to enhance growth treatment and results lies in figuring out which sets of qualities and quality associations influence diverse subsets of tumors. UniversalCancer GenomeConsortium (ICGC) is a deliberate experimental association that gives a discussion to joint effort among the world's driving growth andgenomic analysts. RelatedConferences: 5th InternationalConference on Integrative BiologyJune 19-21, 2017 London, UK; InternationalConference onGenetic Counseling and Genomic Medicine,December 07-08, 2016 Madrid, Spain; 9th InternationalConference on Genomics and PharmacogenomicsJuly 13-14, 2017 Chicago, USA;Conference onSynthetic Biology: Engineering, Evolution & Design (SEED), June 20-23, 2017 Hyatt Regency, Vancouver, British Columbia, Canada. 28th Annual Lorne Genomics Conference 2017 February 12-14, 2017 Mantra Lorne, Victoria, Australia. 29th Fungal Genetics conference March 14-19, 2017 Pacific Grove, CA Related Societies: Canadian Association of Genetic Counsellors, Canada. European Cytogeneticists Association, Europe. Human Genome Organisation, South … Continue reading →

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