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Gene Therapy Viral Vectors Explained

Posted: Published on July 8th, 2016

Viral vectors have natural host cell populations that they infect most efficiently. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are refractory to infection by these viruses as well. Attachment to and entry into a susceptible cell is mediated by the protein envelope on the surface of a virus. Retroviruses and adeno-associated viruses have a single protein coating their membrane, while adenoviruses are coated with both an envelope protein and fibers that extend away from the surface of the virus. The envelope proteins on each of these viruses bind to cell-surface molecules such as heparin sulfate, which localizes them upon the surface of the potential host, as well as with the specific protein receptor that either induces entry-promoting structural changes in the viral protein, or localizes the virus in endosomes wherein acidification of the lumen (anatomy) induces this refolding of the viral coat. In either case, entry into potential host cells requires a favorable interaction between a protein on the surface of the virus and a protein on the surface of the cell. For the purposes of gene therapy, one might … Continue reading

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Biotechnology | Home

Posted: Published on July 4th, 2016

ARE YOU READY FOR A JOB IN BIOTECHNOLOGY? Associate in Applied Science (AAS) Certificate of Specialization (CS) Hands-on lab experience: Earn a new degree, enhance your current degree, or upgrade your professional skills. Internship opportunities: Working for cutting-edge biotechnology companies. A working professional? The entire program is available in evening classes over the course of two years. State-of-the-art facilities that surpass most four-year universities: Two degree options to choose from: Associate in Applied Science: Certificate of Specialization: Hands-on: Students practice lab techniques on millions of dollars worth of equipment covering a variety of bioscience niches the same equipment used by researchers at BRDG Park. Workplace learning: Students benefit from the opportunity to gain real-world experience, and often want to extend beyond the 150-hour minimum per semester. Workplace learning is a requirement in the AAS program, but is also available to students pursuing a certificate. Youll be placed with a company based upon your research interests and current industry needs. On many occasions the companies requesting interns are interested in finding permanent employees, and internships often lead to full-time jobs. Biotechnologists utilize cellular and molecular processes to develop technologies and products that help improve our lives and the health of our … Continue reading

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Biotechnology | Programs & Degrees | Mesa Community College

Posted: Published on July 4th, 2016

The ancient Egyptians used biotechnology to develop beer. Others used it to breed basset hounds, Boston terriers, and bull dogs. More recently, biotechnology has been used to design bleaches that battle the bacteria of major diseases. Biotechnology is the manipulation of biology for some human end. Its the use of microorganisms or biological substances, such as enzymes, to solve problems, make useful products, and perform specific industrial or manufacturing processes. Biotechnology merges biological information with computer technology to advance research in nanotechnology, regenerative medicine, agriculture, and ecology. Applications of biotechnology include the production of pharmaceuticals, synthetic hormones, and bulk foodstuffs, as well as the bioconversion of organic waste and the use of genetically altered bacteria in the cleanup of oil spills. The Biotechnology program at MCC provides you with a working knowledge of biotechnology by focusing on competency and technical expertise with state-of-the-art laboratory protocol and with critical consideration of current topics in biotechnology. Our courses prepare you for a career as a technical assistant in laboratories. The program includes practical experience through an internship. The relatively new biotechnology field is booming. Because of this growth, graduates with the necessary biology and chemistry skills and practical hands-on training will be … Continue reading

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Biology: MS in Biotechnology – California State University …

Posted: Published on July 4th, 2016

The Master's in Biotechnology Program is a Professional Science Master's Program, approved by the Council of Graduate Schools. This application focused graduate program is designed to train students in biotechnology. We are preparing the next generation of leaders in biotechnology. This Section Contains Our graduates are: TOP Biotechnology is a multidisciplinary endeavor that increasingly requires employees fluent in both science and business to enable the development of new technologies and products based on the unique applications of the cellular and molecular life sciences. The Master's Degree in Biotechnology at the California State University, Fresno offers students, who are fundamentally educated in various scientific disciplines, the opportunities to acquire the knowledge and skills required to comprehend and commercialize these emerging technologies and/or their products. TOP TOP As a leading university in the Central Valley, California State University, Fresno will lead the way for new and innovative applications of biotechnology both in the state and throughout the nation. TOP See the original post: Biology: MS in Biotechnology - California State University ... … Continue reading

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Biotechnology | UCSC Extension Silicon Valley

Posted: Published on July 4th, 2016

Biotechnology: One of the Bay Area's Top Growth Industries The Bay Area is a leader in the global biopharmaceutical industry, with local companies and research institutions setting the pace in the discovery and development of biopharmaceuticals to target major unmet medical conditions, such as cardiovascular disease, cancer, AIDS and other degenerative diseases. UCSC Extensions Biotechnology Certificate provides a solid understanding of the scientific disciplines that underlie the industrys activities, a foundation in the principles that guide drug discovery and development, an appreciation of cutting-edge bioscience research and technology, and a broader awareness of todays biopharmaceutical industry. This combination of general and practical knowledge enhances the skills of professionals currently working in this industry and helps prepare others to enter this dynamic field. This program is designed for chemists, biologists and other scientists who want to enhance their knowledge of the principles and applications of biotechnology. It also benefits individuals from other disciplines who need a solid scientific foundation in order to enter or work more effectively in the biopharmaceutical field. Read the original: Biotechnology | UCSC Extension Silicon Valley … Continue reading

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Biotechnology | Wolf Greenfield

Posted: Published on July 4th, 2016

G R O U P S T A T S When it comes to advanced scientific degrees, we field the largest biotechnology group in New England 36 members, over 80% of whom have PhDs or MDs. We aggressively recruit people who develop advanced technology, and who speak the language of inventors and scientists, quickly grasping complex biotechnology matters. Our clients include both large and emerging biotech companies such as Biogen, Dyax Corporation, and Lantheus Medical Imaging, privately financed startup companies,and prestigious academic and research institutions, including MIT, Dana Farber Cancer Institute, and Harvard Medical School. We understand the different needs of each client and bring practical solutions to the table. Our expertise is broadand deep, covering areas from antibodies to transgenic technologiesand everything inbetween. We also call on members of our other practice groups includingChemical & Materials Technologies and Pharmaceuticalwhen their specialized expertise will benefit a clients project. In addition, our teams routinely include support from our paralegal group and our International Filing Department to contain costs and deliver value. Our group's services include: IP strategic planning; patent portfolio development, acquisition, and enforcement; studies on patentability, infringement, and validity; IP audits and due diligence; licensing and technology transfer; defending and … Continue reading

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Mesenchymal Stromal Cells

Posted: Published on July 3rd, 2016

Curr Opin Hematol. Author manuscript; available in PMC 2012 Jun 1. Published in final edited form as: PMCID: PMC3365862 NIHMSID: NIHMS16948 Mesenchymal stromal cells (MSCs) are the spindle shaped plastic-adherent cells isolated from bone marrow, adipose, and other tissue sources, with multipotent differentiation capacity in vitro. However, whether MSCs truly qualify as stem cells is an area of some debate[1]. MSCs were first described by Friendenstein as hematopoietic supportive cells of bone marrow. He showed that MSCs could differentiate to bone in vitro and a subset of the cells had a high proliferative potential (CFU-F) when plated at low density in tissue culture[2,3]. Based largely on Friendensteins work, Maureen Owen proposed the existence of a stromal stem cell to maintain the marrow microenvironment as the hematopoietic stem cell maintains hematopoiesis[4]. The notion of a mesenchymal stem cell was popularized by Arnold Caplan proposing that MSCs gave rise to bone, cartilage, tendon, ligament, marrow stroma, adipocytes, dermis, muscle and connective tissue[5]. However, convincing data to support the stemness of these cells were not forthcoming, and now most investigators recognize that in vitro isolated MSCs are not a homogenous population of stem cells, although a bona fide mesenchymal stem cell may reside … Continue reading

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Immunosuppression by mesenchymal stem cells: mechanisms and …

Posted: Published on July 3rd, 2016

Stem Cell Research & Therapy20101:2 DOI: 10.1186/scrt2 BioMed Central Ltd2010 Published: 15March2010 Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells that are isolated from many adult tissues, in particular from the bone marrow and adipose tissue. Along with their capacity for differentiating into cells of mesodermal lineage, such as adipocytes, osteoblasts and chondrocytes, these cells have also generated great interest for their ability to display immunomodulatory capacities. Indeed, a major breakthrough came with the finding that they are able to induce peripheral tolerance, suggesting they may be used as therapeutic tools in immune-mediated disorders. The present review aims at discussing the current knowledge on the targets and mechanisms of MSC-mediated immunosuppression as well as the potential use of MSCs as modulators of immune responses in a variety of diseases related to alloreactive immunity or autoimmunity Mesenchymal stem cells (MSCs), also named multipotent mesenchymal stromal cells, are largely studied as new therapeutic tools for a number of clinical applications. Indeed, these cells have been shown to have differentiation capacities as well as paracrine effects via the secretion of growth factors, cytokines, antifibrotic or angiogenic mediators [1]. A large body of studies also indicates that MSCs possess an immunosuppressive function both … Continue reading

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The Science of Mesenchymal Stem Cells and Regenerative Medicine

Posted: Published on July 3rd, 2016

Arnold Caplan PhD Seven Part Video Series, all presented conveniently here. June 25, 2013 by jlenner on http://www.CellMedicine.com (VIDEO Part 1) Professor Arnold Caplan of Case Western Reserve University is widely regarded as The Father of the Mesenchymal Stem Cell. This lecture is a must see for anyone interested in stem cell therapy. In Part 1, Prof. Caplan proposes a new regulatory pathway for approval of cell-based therapies and regenerative medicine called Progressive Approval to replace the current US FDA system that is now in place. In Part 2, Prof. Caplan discusses the two types of regenerative medicine: tissue engineering and in vivo tissue regeneration, hematapoietic and mesenchymal stem cells. All mesenchymal stem cells are pericytes and have immuno-modulatory and trophic properties. The Science of Mesenchymal Stem Cells and Regenerative Medicine Arnold Caplan PhD (VIDEO Part 3) In part 3, Professor Caplan discusses the science behind mesenchymal stem cells: sources of mesenchymal stem cells (MSCs), because all MSCs are pericytes one can find them in any tissue that has blood vessels, pericytes express markers of MSCs, frequency of pericytes in human tissue, most abundant source of pericytes is adipose (fat) tissue, adipose-derived stem cells, how MSCs are separated from fat, … Continue reading

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Prochymal Adult Human Mesenchymal Stem Cells for Treatment …

Posted: Published on July 3rd, 2016

Human mesenchymal stem cells (MSCs), derived from healthy adult volunteer human donors, can be obtained from bone marrow donation and cultured in the laboratory. MSCs have shown the ability to find injured tissue, reduce and control inflammation, and assist in tissue repair. Prochymal MSCs will be infused into patients with moderate-to-severe Crohn's disease. Infusions will occur on two separate days, 7-10 days apart. Patients will be monitored for reduced Crohn's disease symptoms. High dose (8 million cells per kg of body weight) Cells in plasmalyte and containing dimethylsulfoxide Other Name: PROCHYMAL two infusions, one week apart, each comprising adult human mesenchymal stem cells Other Name: PROCHYMAL Low dose: 2 million cells per kg body weight Cells in plasmalyte and containing dimethylsulfoxide Other Name: PROCHYMAL two infusions, one week apart, each comprising adult human mesenchymal stem cells Other Name: PROCHYMAL Human mesenchymal stem cells (MSCs), derived from healthy adult volunteer human donors, can be obtained from bone marrow donation and cultured in the laboratory. MSCs have shown the ability to find injured tissue, reduce and control inflammation, and assist in tissue repair. Prochymal MSCs will be infused into patients with moderate-to-severe Crohn's disease. Infusions will occur on two separate days, 7-10 … Continue reading

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