Ulcerative colitis is a chronic inflammatory disease of the large intestine (also known as the large bowel or colon). The most common symptoms are bloody diarrhea and abdominal pain Figure 01. Ulcerative colitis involves periodic inflammation and loss of tissue (ulceration) of the lining of the large intestine. The condition produces frequent bouts of urgent, bloody diarrhea, and sometimes with abdominal cramping. It usually begins in childhood or early adulthood, and is characterized by periods of exacerbations and remissions. During remissions, the person may feel well and be free of symptoms. Ulcerative colitis shares many common characteristics with Crohns disease, another inflammatory bowel disease. About 15% of patients with inflammatory bowel disease have features of both conditions, and cannot be clearly diagnosed with one or the other. Figure 01. Anatomy of the digestive system The more the bowel is inflamed, the more severe the disease. The inflammation and ulceration of ulcerative colitis is present in the rectum, and may spread up through the large intestine in a characteristically continuous manner. Disease severity depends in part on how much of the intestine is affected. If disease is confined to the rectum (proctitis), symptoms are often relatively minor. Proctosigmoiditis is the term … Continue reading
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