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Stem Cells and the FDA

Posted: Published on July 1st, 2015

The Manhattan Regenerative Medicine Medical Group is involved with the Investigational use of Autologous Adipose Derived Stem Cells (ADSCs) for clinical research and deployment. The Manhattan Regenerative Medicine Medical Group is offering patient-funded research to treat individuals with autologous (their own) fat-derived stem cells and are not involved in the use ormanufacturing of any investigational drugs or devices. The Manhattan Regenerative Medicine Medical Group is not offering stem cell therapy as a cure for any condition, disease, or injury. No statements or treatments on this website have been evaluated or approved by the FDA. This website contains no medical advice. All statements and opinions on this website are provided for educational and informational purposes only. We do not diagnose or treat via this website or via telephone. The Manhattan Regenerative Medicine Medical Group does not claim that any applications, or potential applications, using autologous adult stem cell treatments are approved by the FDA, or are even effective. We do not claim that these treatments work for any listed nor unlisted condition, intended or implied. It is important for potential patients to do their own research based on the options that we present so they can make informed decisions. See the … Continue reading →

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Stem cell gene therapy holds promise for eliminating HIV …

Posted: Published on July 1st, 2015

by Mirabai Vogt-James The scientists, led by Jerome Zack (left) and Scott Kitchen, found that the technique decreased HIV levels in mice by 80 to 95 percent. Credit: UCLA Broad Stem Cell Research Center cientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research are one step closer to engineering a tool that could one day arm the body's immune system to fight HIVand win. The new technique harnesses the regenerative capacity of stem cells to generate an immune response to the virus. The findings were published today in the journal Molecular Therapy. "We hope this approach could one day allow HIV-positive individuals to reduce or even stop their current HIV drug regimen and clear the virus from the body altogether," said Scott Kitchen, the study's lead author and a member of the Broad Stem Cell Research Center. "We also think this approach could possibly be extended to other diseases." Kitchen also is a member of the UCLA AIDS Institute and an associate professor of medicine in the division of hematology and oncology at the David Geffen School of Medicine at UCLA. Kitchen and his colleagues were the first to report the use of … Continue reading →

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Muscular Dystrophy: Symptoms, Diagnosis, and Treatment

Posted: Published on July 1st, 2015

What Is Muscular Dystrophy? Muscular dystrophy is a group of diseases that make muscles weaker and less flexible over time. It is caused by a problem in the genes that control how the body keeps muscles healthy. For some people, the disease starts early in childhood. Others dont have any symptoms until they are teenagers or middle-aged adults. How muscular dystrophy affects you or your child depends on the kind. Most peoples condition will get worse over time, and some people may lose the ability to walk, talk, or care for themselves. But that doesnt happen to everyone. Other people can live for many years with mild symptoms. U.S. Children's Medical Needs, by the Numbers Racing champ Jeff Gordon's focus on children's health comes at a crucial time. The number of U.S. children with chronic health conditions has risen dramatically in the past four decades, according to a study published last June in The Journal of the American Medical Association. Some of the study's findings: Of 80 million children in America, about 8% (6.5 million) have chronic conditions that interfere with regular daily activity, says study author James M. Perrin, MD, professor of pediatrics... Read the U.S. Children's Medical Needs, … Continue reading →

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Femto Medicine | Femto Medicine News

Posted: Published on July 1st, 2015

Charles A. Goldthwaite, Jr., PhD. Data from 2007 suggest that approximately 1.4 million men and women in the U.S. population are likely to be diagnosed with cancer, and approximately 566,000 American adults are likely to die from cancer in 2008.1 Data collected between 1996 and 2004 indicate that the overall 5-year survival rate for cancers from all sites, relative to the expected survival from a comparable set of people without cancer, is 65.3%.1 However, survival and recurrence rates following diagnosis vary greatly as a function of cancer type and the stage of development at diagnosis. For example, in 2000, the relative survival rate five years following diagnosis of melanoma (skin cancer) was greater than 90%; that of cancers of the brain and nervous system was 35%. Once a cancer has metastasized (or spread to secondary sites via the blood or lymph system), however, the survival rate usually declines dramatically. For example, when melanoma is diagnosed at the localized stage, 99% of people will survive more than five years, compared to 65% of those diagnosed with melanoma that has metastasized regionally and 15% of those whose melanoma has spread to distant sites.2 The term cancer describes a group of diseases that … Continue reading →

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Stem Cells – Times Topics

Posted: Published on June 30th, 2015

Dec. 20, 2014 Government-backed Japanese institute Riken accepts resignation of Haruko Obokata, one of its highest-profile scientists, after she fails to replicate research results that were once hailed as breakthrough in stem cell research. MORE Experimental stem cell procedures, once talked about but not put into practice, are starting to be used in trial settings; as many as 4,500 clinical trials involving stem cells are under way in United States to treat patients with conditions such as heart disease, blindness, Parkinson's and spinal cord injury; enthusiasm for such procedures, however, sometimes outstrips supporting science. MORE Colleagues of Yoshiki Sasai, leading Japanese life science researcher, say he has taken his own life; Sasai was co-author of discredited stem cell study published in journal Nature that was retracted due to factual errors and allegations of misconduct. MORE Journal Nature retracts two scientific papers it published that initially electrified biologists by describing easy way to make stem cells; says papers were error-filled and had not been verified by anyone else. MORE Op-Ed article by evolutionary geneticist Svante Paabo warns against using sequenced genomes of Neanderthals to re-create Neanderthal individuals; contends from an ethical perspective such an idea should be condemned, and argues that … Continue reading →

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Stem Cell Research & Therapy | Full text | A therapy-grade …

Posted: Published on June 29th, 2015

Abstract Introduction Mesenchymal stem cells (MSCs) are a promising source of cells for regenerative therapies. Although they can be isolated easily from several tissues, cell expansion is limited since their properties are lost with successive passages. Hence, pluripotent derived MSCs (PD-MSCs) arise as a suitable alternative for MSC production. Nevertheless, at present, PD-MSC derivation protocols are either expensive or not suitable for clinical purposes. In this work we present a therapy-grade, inexpensive and simple protocol to derive MSCs from pluripotent stem cells (PSCs) based on the use of platelet lysate (PL) as medium supplement. We showed that the PD-MSCPL expressed multiple MSC markers, including CD90, CD73, CD105, CD166, and CD271, among others. These cells also show multilineage differentiation ability and immunomodulatory effects on pre-stimulated lymphocytes. Thorough characterization of these cells showed that a PD-MSCPL resembles an umbilical cord (UC) MSC and differs from a PSC in surface marker and extracellular matrix proteins and integrin expression. Moreover, the OCT-4 promoter is re-methylated with mesenchymal differentiation comparable with the methylation levels of UC-MSCs and fibroblasts. Lastly, the use of PL-supplemented medium generates significantly more MSCs than the use of fetal bovine serum. This protocol can be used to generate a large amount … Continue reading →

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Human trials of manufactured blood within two years

Posted: Published on June 28th, 2015

Blood cells grown in culture (reticulocytes) The first human trials of lab-produced blood to help create better-matched blood for patients with complex blood conditions has been announced by NHS Blood and Transplant. Research led by scientists at the University of Bristol and NHS Blood and Transplant, used stem cells from adult and umbilical cord blood to create a small volume of manufactured red blood cells. It is hoped that when the production of this lab-produced blood is successfully scaled up, it will offer an alternative to specialist patients with blood disorders such as sickle cell anaemia and thalassemia who require treatment with regular transfusions and for whom it is difficult to find compatible donors. The clinical trial of manufactured red blood cells is designed to compare the survival of red cells manufactured from stem cells with that of standard blood donor red blood cells. This will involve a group of 20 volunteers who will receive a small volume transfusion of between five and ten mls of the lab-produced blood. Dr Ashley Toye from Bristol's School of Biochemistry, who worked alongside Professor Dave Anstee from NHS Blood and Transplant Blood on the project, said: "This announcement is an important stage in … Continue reading →

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The Pros and Cons of Stem Cell Therapy for COPD

Posted: Published on June 26th, 2015

Updated December 29, 2014. Written or reviewed by a board-certified physician. See About.com's Medical Review Board. Stem cells are cells found in bone marrow and other organs. They can develop into any type of tissue that exists in the fully developed body, including any kind of blood cell: red blood cells, white blood cells, or platelets. Because of their unique, regenerative properties, stem cells offer new hope for a variety of diseases, including diabetes mellitis, stroke, osteoporosis, heart disease and, more recently, COPD. Scientists are interested in using stem cells to repair damaged cells and tissues in the body because they are far less likely than to be rejected than foreign cells that originated from another source. There are two types of stem cells that doctors work with most in both humans and animals: Embryonic stem cells are derived from a blastocyst, a type of cell found in mammalian embryos and adults stem cells which are derived from the umbilical cord, placenta or from blood, bone marrow, skin, and other tissues. Embryonic stem cells have the capacity to develop into every type of tissue found in an adult. Embryonic stem cells used for research develop from eggs that have been … Continue reading →

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Mesenchymal stem cell treatment for hemophilia: a review …

Posted: Published on June 25th, 2015

Summary Top of page Summary Introduction Extracellular vesicles produced by stem cells What we have learned from mature liver cell transplantation in humans? MSCs in human clinical applications Disclosure of Conflict of Interests References Hemophilia remains a non-curative disease, and patients are constrained to undergo repeated injections of clotting factors. In contrast, the sustained production of endogenous factors VIII (FVIII) or IX (FIX) by the patient's own cells could represent a curative treatment. Gene therapy has thus provided new hope for these patients. However, the issues surrounding the durability of expression and immune responses against gene transfer vectors remain. Cell therapy, involving stem cells expanded invitro, can provide de novo protein synthesis and, if implanted successfully, could induce a steady-state production of low quantities of factors, which may keep the patient above the level required to prevent spontaneous bleeding. Liver-derived stem cells are already being assessed in clinical trials for inborn errors of metabolism and, in view of their capacity to produce FVIII and FIX in cell culture, they are now also being considered for clinical application in hemophilia patients. Hemophilia A is the most common severe inherited bleeding disorder, affecting 1 in 5000 male births. This pathology exhibits different … Continue reading →

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Parkinson’s Disease Treatments – Standard Treatments for …

Posted: Published on June 22nd, 2015

2001-2008 HAAP Media Ltd Updated February 09, 2015. Although there is as yet no cure for Parkinsons Disease (PD), scientists are hot on the track for better treatments to manage its symptoms. There is also a search for treatments that can slow the progression of the disease. Drug therapy to both manage the symptoms of PD, and slow the progression of the disease, remains the Gold Standard treatment option for PD. Levodopa increases the level of dopamine in the brain and thus relieves the movement problems of PD. Levodopa however has side effects. One of Levodopas common side effects is nausea so it is usually given with a second drug, carbidopa, that prevents nausea. The combination of Levodopa/Carbidopa effectively treats the symptoms of PD, allowing many people with PD to live relatively normal, active, and productive lives for many years. Dopamine Agonists are a class of drugs that, like levodopa, increase dopamine activity in the brain. Commonly prescribed dopamine agonists include: bromocriptine (Parlodel), pergolide (Permax), pramiprexole (Mirapex), and ropinirole (Requip). They do not work as well as levodopa for the movement problems of PD but they may be able to slow progression of the disease. A small percentage of patients … Continue reading →

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