Findings from animal study have implications for disorders such as chronic obstructive pulmonary disease IMAGE:Adult lung cells regenerating: Type 1 cells are green. Type 2 cells are red. New Type 2 derived from Type 1 cells are yellow. Nuclei are blue view more Credit: Jon Epstein, MD & Rajan Jain, MD, Perelman School of Medicine at the University of Pennsylvania, and Christina Barkauskas & Brigid Hogan, Duke University PHILADELPHIA - A new collaborative study describes a way that lung tissue can regenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought. Researchers from the Perelman School of Medicine at the University of Pennsylvania and Duke University, including co-senior authors Jon Epstein, MD, chair of the department of Cell and Developmental Biology, and Brigid L.M Hogan, Duke Medicine, along with co-first authors Rajan Jain, MD, a cardiologist and instructor in the Department of Medicine and Christina E. Barkauskas, also from Duke, report their findings in Nature Communications "It's as if the lung cells can regenerate from one another as needed to repair missing tissue, suggesting that there is much more flexibility in the system than we have previously appreciated," says Epstein. "These aren't … Continue reading →

Contact Information Available for logged-in reporters only Newswise PHILADELPHIA A new collaborative study describes a way that lung tissue can regenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought. Researchers from the Perelman School of Medicine at the University of Pennsylvania and Duke University, including co-senior authors Jon Epstein, MD, chair of the department of Cell and Developmental Biology, and Brigid L.M Hogan, Duke Medicine, along with co-first authors Rajan Jain, MD, a cardiologist and instructor in the Department of Medicine and Christina E. Barkauskas, also from Duke, report their findings in Nature Communications. Its as if the lung cells can regenerate from one another as needed to repair missing tissue, suggesting that there is much more flexibility in the system than we have previously appreciated, says Epstein. These arent classic stem cells that we see regenerating the lung. They are mature lung cells that awaken in response to injury. We want to learn how the lung regenerates so that we can stimulate the process in situations where it is insufficient, such as in patients with COPD [chronic obstructive pulmonary disease]. The two types of airway cells in the alveoli, the … Continue reading →

La Jolla, California (PRWEB) April 13, 2015 The top stem cell therapy clinic in Southern California, Telehealth, is now offering a wound healing guarantee with its innovative stem cell therapy program.The program works exceptionally well for those dealing with nonhealing wounds as a result of diabetes or other issues. Simply call (888) 828-4575 for more information and scheduling at any of the stem cell clinics in La Jolla, Irvine, Orange or Upland. Nonhealing wounds lead to considerable disability and the potential for infection and amputation. Telehealth has developed a stem cell therapy that routinely works for healing these problematic wounds, especially for diabetic ulcers. The stem cell therapy wound healing guarantee includes closing an ulcer wound within 90 days as long as it is less than 2 cm x 4 cm in size. Thankfully, Telehealth is also able to close larger ones as well. The Board Certified physicians have extensive experience with stem cell therapy for all types of musculoskeletal conditions. There are several types of stem cell procedures available at the four locations in La Jolla, Irvine, Orange and Upland. Board certified physicians perform the procedures and oversee the care. In addition to treating nonhealing wounds, Telehealth also treats … Continue reading →

NYC, NY (PRWEB) April 13, 2015 NYC Health & Longevity Center is now offering outpatient stem cell therapy to help patients avoid joint replacement in all extremities. The treatments are performed by a Board Certified physician, with most patients being able to avoid or delay the need for surgery. Simply call (844) GET-STEM for more information and scheduling with stem cell therapy NYC trusts. Millions of joint replacements are performed in the US annually for degenerative arthritis of the knee, hip, shoulder, elbow, wrist and ankle. While these are mostly effective, they are not risk free procedures and should be avoided as long as possible. In addition, the implants placed are not meant to last forever. With stem cell therapy now being commercially available, individuals now have access to the most cutting-edge procedures with the potentially to actually regenerate damaged tissue. This includes cartilage, ligament and tendon. The stem cell procedures are performed by a Board Certified Anti-Aging doctor with considerable experience in both the stem cell procedures along with prolotherapy too. The stem cell material comes from amniotic fluid that is obtained from consenting donors after a scheduled C-section, which is then processed at an FDA regulated lab. No … Continue reading →

LUBBOCK, Texas (AP) Ravaged by a stroke that left him unable to walk and barely able to speak, Gordie Howe had decided it was time to quit. His sons didn't want to hear it. Not from Mr. Hockey, whose 25-year career in the NHL was defined by his indomitable style of play and blend of grit and finesse. "He was saying, 'Take me out back and shoot me,'" recalled Murray Howe, a diagnostic radiologist. "He was serious. It wasn't like a joke. I said, 'Dad, let's just see if we can help you first.'" They found it in Mexico, where experimental stem cell treatments produced what his family called a "life changing" turnaround that has put the 87-year-old Howe back on his feet. A second round of treatments is planned in June. Recent years have been challenging for Howe, who set NHL marks with 801 goals and 1,850 points mostly with the Detroit Red Wings that held up until Wayne Gretzky surpassed him. He retired from hockey for good, but not until he was 52. The body he counted on as an athlete has stayed relatively strong, but memory loss from the early stages of dementia became a problem even … Continue reading →

Mesenchymal stem cells captured in microcapsules. Each microcapsule is roughly 40 micrometers across. A team of Cornell scientists has shown that stem cells confined inside tiny capsules secrete substances that help heal simulated wounds in cell cultures, opening up new ways of delivering these substances to locations in the body where they can hasten healing. The capsules need to be tested to see if they help healing in animals and humans, but they could eventually lead to living bandage technologies: wound dressings embedded with capsules of stem cells to help the wound regenerate. Microencapsulated equine mesenchymal stromal cells promote cutaneous wound healing in vitro appeared in the April 10Stem Cell Research & Therapy. The encapsulation seems to increase the stem cells regenerative potential, said Gerlinde Van de Walle of the Baker Institute for Animal Health in the College of Veterinary Medicine, adding that the reasons why are not yet known. It's possible that putting them in capsules changes the interactions between stem cells or changes the microenvironment. To her knowledge, Van de Walle said, this is the first time encapsulated stem cells have been used to treat wounds. Her team used horse stem cells and cell cultures because, unlike mice, … Continue reading →

New research published online in Blood, the Journal of the American Society of Hematology (ASH), reports that children with "bubble boy disease" who undergo gene therapy have fewer infections and hospitalizations than those receiving stem cells from a partially matched donor. The research is the first to compare outcomes among children with the rare immune disorder -- also known as X-linked severe combined immunodeficiency (SCID-X1) -- receiving the two therapeutic approaches. Children with SCID-X1 are born with a genetic defect that prevents them from developing a normal immune system. Because they are prone to life-threatening infections, infants with SCID-X1 must be kept in a sterile, protective bubble and require extensive treatment for survival beyond infancy. Infants with SCID are most likely to survive if they receive a stem cell transplant from a fully matched donor -- typically a sibling -- a procedure that replaces an infant's diseased stem cells with healthy donor cells. Following a successful fully matched transplant, infants with SCID-X1 are able to produce their own immune cells for the first time. In the absence of a fully matched stem cell donor, infants with SCID-X1 may receive a transplant from a partial, or "half-matched," donor -- typically their … Continue reading →