A recently completed clinical trial for a new drug being developed by Prothena Corporation is sparking excitement within the Parkinson's community. The drug, PRX-002 demonstrated a key ability to reduce the presence of an enzyme thought to be associated with causing Parkinson's disease, and if that results in an ability to slow disease progression, it could mark an important turning point in the treatment of this vexing indication. Source: Prothena Corporation. First, a bit of background Parkinson's disease is a tough-to-treat neurological disease that affects up to 1 million Americans. More than 60,000 new cases of Parkinson's disease are diagnosed every year in the United States, and treatment options remain limited. Globally, it is estimated that there are between 7 and 10 million people living with Parkinson's disease. Typically, Parkinson's disease patients' symptoms are treated with levodopa. While levodopa isn't a cure, it does help patients control their tremors and muscle stiffness. Additional drugs used in the treatment of Parkinson's symptoms include medicines that help mimic dopamine activity, ones that prevent dopamine levels from falling, and drugs that block the neurotransmitter acetylcholine in the nervous system. While these drugs do help reduce patient symptoms early on, they fall short of … Continue reading
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