Contact Information Available for logged-in reporters only Newswise March 19, 2015(Bronx, NY)Scientists at Albert Einstein College of Medicine of Yeshiva University and their international collaborators have developed a novel fluorescence microscopy technique that for the first time shows where and when proteins are produced. The technique allows researchers to directly observe individual messenger RNA molecules (mRNAs) as they are translated into proteins in living cells. The technique, carried out in living human cells and fruit flies, should help reveal how irregularities in protein synthesis contribute to developmental abnormalities and human disease processes including those involved in Alzheimers disease and other memory-related disorders. The research will be published the March 20 edition of Science. Weve never been able to pinpoint exactly when and where mRNAs are translated into proteins, said study co-leader Robert H. Singer, Ph.D., professor and co-chair of anatomy and structural biology and co-director of the Gruss Lipper Biophotonics Center at Einstein. This capability will be critical for studying the molecular basis of disease, for example, how dysregulation of protein synthesis in brain cells can lead to the memory deficits that occur in neurodegeneration. Dr. Singer also holds the Harold and Muriel Block Chair in Anatomy & Structural Biology … Continue reading
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