A new technique for creating artificial DNA that is faster, more accurate and more flexible than existing methods has been developed by scientists at Imperial College London. The new system - called BASIC - is a major advance for the field of synthetic biology, which designs and builds organisms able to make useful products such as medicines, energy, food, materials and chemicals. To engineer new organisms, scientists build artificial genes from individual molecules and then put these together to create larger genetic constructs which, when inserted into a cell, will create the required product. Various attempts have been made to standardise the design and assembly process but, until now, none have been completely successful. BASIC, created by researchers from Imperial's Centre for Synthetic Biology & Innovation, combines the best features of the most popular methods while overcoming their limitations, creating a system that is fast, flexible and accurate. The new technique should enable greater advances in research and could offer industry a way to automate the design and manufacture of synthetic DNA. Dr Geoff Baldwin, from Imperial's Department of Life Sciences, explains: "BASIC uses standardised parts which, like Lego, have the same joining device, so parts will fit together in … Continue reading
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