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Behind the scenes of the world's first commercial stem-cell therapy

Posted: Published on March 4th, 2015

Contrasto/eyevine Biologist Graziella Pellegrini has worked on stem-cell therapy at four different Italian institutions, including a hospital run by priests. Last month saw a major landmark for regenerative medicine: the first time that a stem-cell therapy beside the use of cells extracted from umbilical cords had been cleared for sale by any regulatory agency in the world. The European Commission approved Holoclar for use in cases of blindness caused by burning. The achievement is all the more remarkable because Holoclar was developed by a small laboratory in Italy, a country better known for its lack of support for life sciences and for its recent tolerance of an unproven stem-cell concoction, marketed by the Stamina Foundation, that claimed to be a panacea for many diseases. Nature talked to Graziella Pellegrini from the University of Modena about how she and her colleagues overcame the many obstacles to take the therapy from bench to bedside. The surface of the cornea the transparent tissue that sits in front of the iris is constantly renewed in a healthy eye, to keep it smooth and clear. New corneal cells are generated from a niche of stem cells in the limbus, an area between the cornea and … Continue reading

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Gene Therapy Market Report 2014-2024 – Technologies, Markets and Companies

Posted: Published on March 3rd, 2015

DUBLIN, Mar. 03, 2015 /PRNewswire/ --Research and Markets (http://www.researchandmarkets.com/research/gxqhg9/gene_therapy) has announced the addition of Jain PharmaBiotech's new report "Gene Therapy - Technologies, Markets and Companies" to their offering. Gene therapy technologies are described in detail including viral vectors, nonviral vectors and cell therapy with genetically modified vectors. Gene therapy is an excellent method of drug delivery and various routes of administration as well as targeted gene therapy are described. There is an introduction to technologies for gene suppression as well as molecular diagnostics to detect and monitor gene expression. Clinical applications of gene therapy are extensive and cover most systems and their disorders. Full chapters are devoted to genetic syndromes, cancer, cardiovascular diseases, neurological disorders and viral infections with emphasis on AIDS. Applications of gene therapy in veterinary medicine, particularly for treating cats and dogs, are included. Research and development is in progress in both the academic and the industrial sectors. The National Institutes of Health (NIH) of the US is playing an important part. As of 2014, over 2050 clinical trials have been completed, are ongoing or have been approved worldwide.A breakdown of these trials is shown according to the geographical areas and applications. Since the death of Jesse … Continue reading

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Global Gene Therapy Market Report 2015-2025 – Extensive Study on the Marketed and Pipeline Gene Therapies

Posted: Published on March 3rd, 2015

DUBLIN, Mar. 03, 2015 /PRNewswire/ --Research and Markets (http://www.researchandmarkets.com/research/rcv4lq/gene_therapy) has announced the addition of the "Gene Therapy Market, 2015 - 2025" report to their offering. The "Gene Therapy Market, 2015-2025" report provides an extensive study on the marketed and pipeline gene therapies. A lot of research has been carried out in this field for over a decade but there are only five approved therapies (four available in Asian markets; one approved in the EU). There are many promising therapies which are currently being developed worldwide; the approach is likely to result in several commercial success stories in the foreseen future. The report covers various aspects, such as key players, marketed gene therapy products, products in clinical / pre-clinical research, associated ethical issues, likely future developments and upcoming opportunities for a variety of stakeholders. Several disorders that arise inside the body are a result of either a direct genetic aberration or a dysfunctional/non-functional protein. The attempt to use nucleic acids to correct or delete the genes causing a particular disease is known as gene therapy. Although gene therapy has not contributed significantly to the global pharmaceutical market yet, it is anticipated to grow at a fast pace over the next decade. … Continue reading

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RDBY- Fusion Getting That Darn Dna bomb – Video

Posted: Published on March 3rd, 2015

RDBY- Fusion Getting That Darn Dna bomb "Fixing Common Mistakes with Dna bombs" RDBY Lets Get That 30Gunstreak! Finally getting to the bottom of these mistakes we dropped the dna bomb yesterday and im very confident about getting... By: RD BY … Continue reading

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RDBY- “Ready for action Dna bomb time” – Video

Posted: Published on March 3rd, 2015

RDBY- "Ready for action Dna bomb time" "Fixing Common Mistakes with Dna bombs" RDBY Lets Get That 30Gunstreak! Finally getting to the bottom of these mistakes we dropped the dna bomb yesterday and im very confident about getting... By: RD BY … Continue reading

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DNA KF5 on Comeback – Video

Posted: Published on March 3rd, 2015

DNA KF5 on Comeback BELLA RAGAZZI OGGI VI PORTO UNA SEMPLICE DNA DI KF5 ... SE IL VIDEO VI PIACE VI INVITO A LASCIARE UNLIKE UN COMMENTINO E AD ISCRIVERVI AL CANALE!BELLA!!!!! By: itFK VoRTaGe … Continue reading

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DNA PODER IS MY CLIKA HOMIE – Video

Posted: Published on March 3rd, 2015

DNA PODER IS MY CLIKA HOMIE DESDE 1998. By: acseroner … Continue reading

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Where did Europe get its languages? Scientists uncover new evidence.

Posted: Published on March 3rd, 2015

Beginning some 4,500 years ago, herders living in the temperate grasslands north of the Black and Caspian Seasbegan moving westward into Europe. The mass migration continued for about 15 centuries, and with it came horses, wheeled vehicles, and a new kind of language. This, at least, is the hypothesis supported by an analysis of ancient DNA,published Monday in the journal Nature.By examining the entire genomes of 69 Europeans who lived between 8,000 and 3,000 years ago, a team of international researchers has pinpointed the effects of a large-scale movement of people with Near East ancestry into central Europe.Their language, say the researchers, might be the source of some of the Indo-European languages spoken throughout Europe today. With more than three billion speakers, the Indo-European family, which includes English, Latin and its descendants, Sanskrit and its descendants, the Slavic languages, the Celtic languages, Russian, Greek, Farsi, Kurdish, Pashto, and hundreds of others, is the world's largest family of languages. Almost all of the languages of contemporary Europe, with the notable exceptions of Finnish, Hungarian, Estonian, are part of this family. But where did Indo-European come from, and how did it wind up in Europe? Most historical linguists fall into one oftwo … Continue reading

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The Importance of Chemistry to Human Health – Antibiotics, The War on Bacteria – Video

Posted: Published on March 3rd, 2015

The Importance of Chemistry to Human Health - Antibiotics, The War on Bacteria This video has been shortlisted by the RSC, please'like' and follow this link to place your vote! http://www.rsc.org/Membership/Networking/InterestGroups/OrganicDivision/take-1-competition/videos... By: Tom Fleming … Continue reading

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College of Idaho students explore possible medicinal uses of sagebrush

Posted: Published on March 3rd, 2015

College of Idaho chemistry professor Dr. Carolyn Dadabay and her student research team are deconstructing sagebrush leaves from local deserts to look for bioactive chemicals that could inhibit the bodys detoxification system. In short, theyre researching medicinal uses of sagebrush. In the right dose amount, the chemicals could help the human body keep medication in its system for longer periods of time, officials said. One of the biggest problems in developing drugs that work effectively is that your body is very good at getting rid of drugs, Dadabay pointed out. It has different mechanisms for getting rid of foreign compounds, and it uses those mechanisms to get rid of drugs. Then the drugs dont work. Recently, students from the C of I and research partner Boise State University were collecting two types of sagebrush - whats known as basin big sagebrush and low sagebrush. The students snipped off leaves and put them into ziplock bags destined for the lab. While the College of Idaho is running a preclinical study on the compounds found in sagebrush, collaborator and Boise State biology professor Dr. Jennifer Forbey is looking at the ecological side of what compounds attract pygmy rabbits and sage grouse to … Continue reading

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