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A novel immunotherapy technique to treat patients with osteosarcoma and neuroblastoma

Posted: Published on February 27th, 2015

New York City--A novel phase 1 clinical trial that leverages T-cell immunotherapy is now under way at Karmanos Cancer Institute (KCI) in Detroit and Memorial Sloan-Kettering Cancer Center in New York City; bringing new hope to children and young adults with osteosarcoma and neuroblastoma. This new clinical trial is being funded by charity partners Solving Kids' Cancer and Fishin' For The Cure. T-cell therapy to treat both adult and childhood cancers has been in recent news for the dramatic responses seen in some patients, who've experienced a complete remission or have no more cancer cells in their body. A type of immunotherapy, T-cell therapy trains a patient's own white blood cells that are collected and engineered to recognize specific targets on the surface of cancer cells. These "armed" T-cells are cloaked with a bi-specific T-cell engaging antibody (BiTE) using a new humanized antibody called hu3F8, and returned to the patients as a vaccine with one mission, kill cancer cells. Scientists believe that by incorporating this BiTE antibody, the T-cells will be more effective. "Children and young adults battling osteosarcoma and neuroblastoma need curative treatment options after chemotherapy and targeted drugs stop working," said Tracy Russo, the Executive Director of Fishin' … Continue reading

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Stem cell therapy a boon to Parkinson’s patients

Posted: Published on February 27th, 2015

Bengaluru:Feb 27, 2015, DHNS Two courses of stem cell therapy have helped Ashok Kumar, 59, who suffered from tremors and rigidity due to Parkinsons disease, recover completely, much to the joy of his family. The man was brought inside my cabin in a wheelchair. He was unable to even sit on the chair without support. Today, he walks independently. Stem cell therapy has made it possible for him, said Dr Naseem Sadiq, Director, Plexus Neuro and Stem Cell Research Centre, who began treating Kumar in October, last year. Previously, medication and surgical procedure were the only treatment option for Parkinsons disease. Medication in the long-term often lacks effectiveness and may cause side effects, while surgery is not always feasible. Lately, stem cell therapy has turned out to be a boon for patients with Parkinsons, Dr Sadiq said. Kumar is among the few who have benefited from stem cell therapy. However, though the State has been reporting an increase in the number of registered stem cell donors, it is far behind sufficient as the genetic match between donor and recipient could be anywhere between one in 10,000 and one in two million, according to experts. Speaking to Deccan Herald, Raghu Rajgopal, … Continue reading

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Cardiologists urge caution with daily aspirin for non-heart attack patients

Posted: Published on February 27th, 2015

At Martin ORiordans cardiology practice in the Philadelphia area, it happens weekly. A 45- or 50-year-old patient mentions that her father had a heart attack at the same age. Worried that the same fate will befall her despite being in good health, she takes baby aspirin every day. ORiordans typical response: Please stop. Physicians have known for decades that daily, low-dose aspirin makes sense for patients who have had a heart attack or stroke, as it sharply reduces the chance of having a second one. But for people who have never had one of these cardiovascular events, the thinking on aspirin is less clear, despite two recent large-scale studies. The reason for caution is the very reason that aspirin wards off heart attacks and strokes: It interferes with blood clotting, putting the patient at higher risk of serious gastrointestinal bleeding. Bottom line: Aspirin is more potent than many people realize, said ORiordan, of Mercy Cardiology. People have kind of looked at it as, Aspirin, an apple, a glass of milk, its all good for you, said ORiordan, who is on staff at Lankenau Medical Center. Aspirin is a medication. It is a medication drawing renewed scrutiny, 30 years after the … Continue reading

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EMBL Conference: Microfluidics 2014 – Video

Posted: Published on February 27th, 2015

EMBL Conference: Microfluidics 2014 The EMBL Microfluidics Conference 2014 brought together top researchers in the field to discuss the use of Microfluidics in biology, sparking scientific exch... By: European Molecular Biology Laboratory (EMBL) … Continue reading

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Inaugurazione NY-MaSBiC New York Marche Structural Biology Center – Video

Posted: Published on February 27th, 2015

Inaugurazione NY-MaSBiC New York Marche Structural Biology Center Inaugurazione NY-MaSBiC New York Marche Structural Biology Center. By: UNIVPM … Continue reading

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Malaria transmission linked to mosquitoes’ sexual biology

Posted: Published on February 27th, 2015

Sexual biology may be the key to uncovering why Anopheles mosquitoes are unique in their ability to transmit malaria to humans, according to researchers at Harvard T. H. Chan School of Public Health and University of Perugia, Italy. Through analysis of 16 Anopheles genomes, they found that these mosquitoes' reproductive traits evolved along with their capacity to transmit the Plasmodium parasite that causes malaria. These findings may provide a new target for malaria control, particularly in regions hardest hit by the disease. "Our study is the first to reveal the evolutionary dynamics between the sexes that are likely responsible for shaping the ability of Anopheles mosquitoes to transmit malaria to humans," said senior author Flaminia Catteruccia, associate professor of immunology and infectious diseases at Harvard Chan School and University of Perugia. The study was published online February 26, 2015 in Science. Anopheles mosquitoes are the only mosquitoes capable of transmitting human malaria; however, the species within this genus vary widely in their ability to do so, for reasons that remain unknown. The researchers analyzed nine globally dispersed Anopheles species, enabling reconstruction of the evolutionary history of their reproductive traits and capacity to transmit malaria. They found that two key male … Continue reading

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Aggressive plant fungus threatens wheat production

Posted: Published on February 27th, 2015

The spread of exotic and aggressive strains of a plant fungus is presenting a serious threat to wheat production in the UK, according to research published in Genome Biology IMAGE:This is a close up photo of yellow rust on wheat leaf. view more Credit: Andrew Davis, John Innes Centre The spread of exotic and aggressive strains of a plant fungus is presenting a serious threat to wheat production in the UK, according to research published in Genome Biology. The research uses a new surveillance technique that could be applied internationally to respond to the spread of a wide variety of plant diseases. Wheat is a critical staple and provides 20% of the calories and over 25% of the protein consumed by humans. 'Yellow rust' caused by the fungus Puccinia striiformis f. sp. tritici (PST) is one of the plant's major diseases and is widespread across the major wheat-producing areas of the world. Infections lead to significant reductions in both grain quality and yield, with some rare events leading to the loss of an entire crop. New fungus strains have recently emerged that adapt to warmer temperatures, are more aggressive and have overcome many of the major defensive genes in wheat. … Continue reading

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Bumblebees make false memories too

Posted: Published on February 27th, 2015

IMAGE:New evidence suggests bumblebees may experience 'confusion' between flower patterns. view more It's well known that our human memory can fail us. People can be forgetful, and they can sometimes also "remember" things incorrectly, with devastating consequences in the classroom, courtroom, and other areas of life. Now, researchers show for the first time in the Cell Press journal Current Biology on February 26 that bumblebees can be unreliable witnesses too. The new study is the first to explore false memories in any non-human animals, the researchers say. They now suspect that the phenomenon may be widespread in the animal kingdom. "We discovered that the memory traces for two stimuli can merge, such that features acquired in distinct bouts of training are combined in the animal's mind," says Lars Chittka of Queen Mary University of London. As a result, "stimuli that have actually never been viewed before, but are a combination of the features presented in training, are chosen during memory recall." Bumblebees are rather clever animals, which explains why Chittka has been studying learning and memory in the insects for the last 20 years. The bees can remember the patterns, colors, and scents of various kinds of flowers. They can … Continue reading

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Researchers demonstrate optogenetic stimulation of the brain to control pain

Posted: Published on February 27th, 2015

IMAGE:Samarendra Mohanty, an assistant professor of physics, leads the Biophysics and Physiology Lab in the UT Arlington College of Science. view more Credit: UT Arlington ARLINGTON, Texas -- A new study by a University of Texas at Arlington physics team in collaboration with bioengineering and psychology researchers shows for the first time how a small area of the brain can be optically stimulated to control pain. Samarendra Mohanty, an assistant professor of physics, leads the Biophysics and Physiology Lab in the UT Arlington College of Science. He is co-author on a paper published online Wednesday by the journal PLOS ONE. Researchers found that by using specific frequency of light to modulate a very small region of the brain called the anterior cingulate cortex, or ACC, they could considerably lessen pain in laboratory mice. Existing electrode based ACC stimulation lacks specificity and leads to activation of both excitatory and inhibitory neurons. "Our results clearly demonstrate, for the first time, that optogenetic stimulation of inhibitory neurons in ACC leads to decreased neuronal activity and a dramatic reduction of pain behavior," Mohanty said. "Moreover, we confirmed optical modulation of specific electrophysiological responses from different neuronal units in the thalamus part of the brain, … Continue reading

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How to Pike Jump Muscle Anatomy EasyFlexibility – Video

Posted: Published on February 27th, 2015

How to Pike Jump Muscle Anatomy EasyFlexibility http://easyflexibility.com/collections/hamstrings-flexibility/products/double-forward-bend-or-double-hamstrings-flexibility Testing the flexibility of both h... By: Elasticsteel … Continue reading

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