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T-Cell Therapy Clinical Trial Now Offered to Cancer Patients at C.S. Mott Children’s Hospital

Posted: Published on February 24th, 2015

Contact Information Available for logged-in reporters only Newswise ANN ARBOR, Mich. A clinical trial using T-cell therapy that uses the patients own immune cells to hunt down cancer cells is now being offered at the University of Michigans C.S. Mott Childrens Hospital. For patients for whom weve exhausted all other options, this therapy has provided hope against a highly aggressive form of ALL, in situations where nothing else has been successful, says John Levine, M.D., clinical director of the Pediatric Blood and Marrow Transplantation Program at C.S. Mott Childrens Hospital. To begin the treatment process, researchers first extract a patients own T cells. They then use bioengineering techniques to reprogram each patients T cells into chimeric antigen receptor cells the CTL019 cells custom-designed to bind to a protein called CD19 that exists only on the surface of B cells. After being returned to the patients body, the CTL019 cells proliferate and then hunt B cells that express CD19. They also may persist in the circulation, which may guard against the cancers recurrence. We are very proud to play an active role in this exciting new research that can offer new breakthroughs and hope for our pediatric cancer patients, says Levine, … Continue reading →

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MorphoJ Tutorial 1- 4ED3 (Evolutionary Developmental Biology) – Video

Posted: Published on February 24th, 2015

MorphoJ Tutorial 1- 4ED3 (Evolutionary Developmental Biology) MorphoJ is a GUI based program for performing Geometric Morphometric Analysis. MorphoJ is written and maintained by Dr. Chris Klingenberg at the University o... By: Ian Dworkin … Continue reading →

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What animal would Sir David Attenborough most like to be? – Video

Posted: Published on February 24th, 2015

What animal would Sir David Attenborough most like to be? Watch the full interview on the Biology: Changing the world website: http://www.societyofbiology.org/bcw-interviews/sir-david-attenborough Sir David Attenborough Hon FSB, world famous naturalist... By: Society of Biology … Continue reading →

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Plaque to honour Dolly the sheep, the world’s first cloned mammal, to be erected in Edinburgh

Posted: Published on February 24th, 2015

The first mammal to be cloned from an adult cell, she was born in 1996 and died in 2003. On Wednesday a blue plaque celebrating Dolly and the team who created her will be unveiled by the Society of Biology at The Roslin Institute, University of Edinburgh, where she was created. It is one of a new series of 10 celebratory plaques being unveiled by the Society of Biology across the UK to celebrate eminent but sometimes unsung heroes of the science. Others being honoured include IVF pioneers Patrick Steptoe, Robert Edwards and Jean Purdy, Richard Owen, who invented the word "dinosaur", and Dorothy Hodgkin, who discovered the structure of penicillin. Sir Ian Wilmut, from the University of Edinburgh and lead researcher on the Dolly project, will give a speech at the unveiling ceremony. He said: "The birth of Dolly, the first clone of an adult animal, revolutionised our understanding of the mechanisms that regulate development. "We used to believe that once a cell had differentiated to a specific tissue type it could not be changed. The birth of Dolly showed that this is not the case. "This result stimulated research which is now providing revolutionary opportunities in medicine." Dr … Continue reading →

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First black doctor who taught at University remembered, honored

Posted: Published on February 24th, 2015

News Author of The Biology of the Negro challenged the foundation of racism in the 1940s. Posted Feb 24, 2015 by Lorentz Hansen Dr. Julian H. Lewis, the first black doctor to teach at the University of Chicago and author of The Biology of the Negro, a book which scientifically disproved the idea of a superior race, was remembered in a talk on February 21 at the Logan Center as part of the Integrating the Life of the Mind exhibit in celebration of Black History Month. The event featured a panel that consisted of independent scholar Robert Branch II; University of Kansas School of Medicine Chair of History and Philosophy of Medicine Dr. Christopher Crenner; and Founder, Director, and Curator of the Robbins Historical Society and Museum Tyrone Haymore. It was co-sponsored by the Civic Knowledge Project, the Office of Campus and Student Life, Alpha Phi Alpha fraternity, and the University of Chicago Association of Black Alumni. Bart Schultz, executive director of the Civic Knowledge Project and moderator of the event, described the importance of this and other events in the exhibit call[ing] attention to important history, still too often neglected. The idea of neglected history resonated throughout the course … Continue reading →

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Dolly the sheep set to be honoured with plaque celebrating heroes of biology

Posted: Published on February 24th, 2015

DOLLY the sheep is to be honoured with a plaque as part of a project to celebrate heroes of biology. The first mammal to be cloned from an adult cell, she was born in 1996 and died in 2003. On Wednesday a blue plaque celebrating Dolly and the team who created her will be unveiled by the Society of Biology at The Roslin Institute, University of Edinburgh , where she was created. It is one of a new series of 10 celebratory plaques being unveiled by the Society of Biology across the UK to celebrate eminent but sometimes unsung heroes of the science. Others being honoured include IVF pioneers Patrick Steptoe, Robert Edwards and Jean Purdy, Richard Owen, who invented the word "dinosaur", and Dorothy Hodgkin, who discovered the structure of penicillin. Sir Ian Wilmut, from the University of Edinburgh and lead researcher on the Dolly project, will give a speech at the unveiling ceremony. He said: "The birth of Dolly , the first clone of an adult animal , revolutionised our understanding of the mechanisms that regulate development. "We used to believe that once a cell had differentiated to a specific tissue type it could not be changed. The … Continue reading →

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Europe Approves Holoclar, the First Stem Cell-Based Medicinal Product

Posted: Published on February 24th, 2015

PARMA and MODENA, Italy, February 23, 2015 /PRNewswire/ -- The collaborationbetween a public excellent researchcenteranda solidprivate pharmaceuticalcompany allowed toachievean extraordinary result, entirely "made in Italy":the first medicinal productcontainingstem cellsapproved in the Western world The European Commission has granted a conditional marketing authorization, under Regulation (EC) No 726/2004, to Holoclar, an advanced therapy based on autologous stem cells and capable to restore the eyesight of patients with severe cornea damage. Holoclar is manufactured by Holostem Terapie Avanzate (HolostemAdvanced Therapies) - a spin-off of the University of Modena and Reggio Emilia - at the Centre for Regenerative Medicine "Stefano Ferrari" (CMR) of the same University. (Logo: http://photos.prnewswire.com/prnh/20150223/731609-a ) (Logo: http://photos.prnewswire.com/prnh/20150223/731609-b ) (Logo: http://photos.prnewswire.com/prnh/20150223/731609-c ) "Holoclaris theveryfirstmedicinalproductbased onstem cellsto beapproved andformallyregisteredin the Western world," states AndreaChiesi, Director of R&D Portfolio Management of Chiesi Farmaceutici S.p.A. and CEO of Holostem Terapie Avanzate. "This record," continues AndreaChiesi,"shows that thepartnershipbetween the public and privatesectorsis not only possible,butisprobably the best strategy for the development of stem cell-based regenerative medicine, particularly when autologous cells are used.Holostemisnowconsideredasabusiness modeltotranslate into clinicstheresultsobtained byscientific researchin this field." Underlying Holoclar are more than 20 years of excellence in research, conducted by a team of internationally renowned scientists in the field of epithelial stem … Continue reading →

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ESPERITE (Euronext ESP) pioneers first treatment worldwide of Cerebral Palsy using two types of stem cells

Posted: Published on February 24th, 2015

CryoSave, part of ESPERITE, is the only private cord blood bank sponsoring a GCPclinical trial according to GMP-ATMP international guidelines CryoSave leads and sponsors a multicentre clinical trial following GCP-ICHstandards, for investigation of new treatment of Cerebral Palsy using dual infusionof two types of stem cells derived from umbilical cord blood and cord tissueprocessed by CryoSave Geneva, Switzerland - 23 February 2015 The clinical trial aims to demonstrate safety and preliminary efficacy of sequential intravenousinfusion of the ex vivo expanded mesenchymal stem cells (MSC) derived from cord tissue and thecord blood stem cells. The study will use, for the first time in clinical research, autologous MSC derived from cryopreserved cord tissue. The clinical trial, sponsored by CryoSave, will be performedin collaboration with Professor Manuel Ramrez Orellana, the Principal Investigator, and ProfessorLuis Madero, the Clinical Supervisor from the University Hospital Nio Jesus in Madrid, Spain. Cerebral Palsy is a devastating disease diagnosed in 1 per 326 children according to CDC, with noavailable treatment. 17 Million people worldwide live affected by cerebral Palsy (CPIRF). 26 BillionUSD are spent every year to accommodate the life of these patients in the US (WHO). Original post: ESPERITE (Euronext ESP) pioneers first treatment worldwide of Cerebral … Continue reading →

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TiGenix: TiGenix's Phase III trial design for Cx601 endorsed by President-Elect of ECCO

Posted: Published on February 24th, 2015

PRESS RELEASE TiGenix's Phase III trial design for Cx601 endorsed by President-Elect of ECCO Leuven (BELGIUM) - 23 February, 2015 -TiGenix NV (Euronext Brussels: TIG), an advanced biopharmaceutical company focused on developing and commercialising novel therapeutics from its proprietary platform of allogeneic expanded adipose-derived stem cells in inflammatory and autoimmune diseases, announced today that Dr Julian Pans, a leading clinical specialist in inflammatory bowel disease, endorsed the design of the Company's Phase III trial of Cx601 for the treatment of complex perianal fistulas in patients with Crohn's disease during his presentation last week at the 10th Annual Congress of the European Crohn's and Colitis Organisation (ECCO) held in Barcelona, Spain. Cx601 is a suspension of allogeneic expanded adipose-derived stem cells (eASCs) delivered locally through intra-lesional injection that is being developed for the treatment of perianal fistulas in Crohn's disease patients. Such fistulas cause severe complications and are difficult to manage, and have a significant negative impact on patient quality of life and psychological well-being. There is currently no effective treatment. In 2009, the European Commission granted Cx601 orphan designation for the treatment of anal fistulas, recognising the debilitating nature of the disease and the lack of treatment options. TiGenix is … Continue reading →

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Kids, Allergies And A Possible Downside To Squeaky Clean Dishes

Posted: Published on February 23rd, 2015

Could using a dishwashing machine increase the chances your child will develop allergies? That's what some provocative new research suggests but don't tear out your machine just yet. The study involved 1,029 Swedish children (ages 7 or 8) and found that those whose parents said they mostly wash the family's dishes by hand were significantly less likely to develop eczema, and somewhat less likely to develop allergic asthma and hay fever. "I think it is very interesting that with a very common lifestyle factor like dishwashing, we could see effects on allergy development," says Dr. Bill Hesselmar of Sweden's University of Gothenburg, who led the study. The findings are the latest to support the "hygiene hypothesis," a still-evolving proposition that's been gaining momentum in recent years. The hypothesis basically suggests that people in developed countries are growing up way too clean because of a variety of trends, including the use of hand sanitizers and detergents, and spending too little time around animals. As a result, children don't tend to be exposed to as many bacteria and other microorganisms, and maybe that deprives their immune system of the chance to be trained to recognize microbial friend from foe. That may make … Continue reading →

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