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Unlikely that topical pimecrolimus associated with increased risk of cancer

Posted: Published on February 18th, 2015

The topical medicine pimecrolimus to treat eczema (atopic dermatitis or AD) in children appears unlikely to be associated with increased of risk of cancer based on how it was used in group of children followed for 10 years, according to an article published online by JAMA Dermatology. Eczema is a common and chronic inflammatory skin condition that most frequently occurs in the first decade of life. The U.S. Food and Drug Administration (FDA) and the European Union Medicines Agency have approved few topical agents to treat eczema in children, but in 2001 the FDA and the European Medicines Agency in 2002 approved pimecrolimus to treat eczema in children at least 2 years old. A "black box warning" describes the potential risk of malignancy associated with the topical use of pimecrolimus, a topical calcineurin inhibitor (TCIs). Oral calcineurin inhibitors were originally approved as immunosuppressive treatments for patients after solid organ transplant to prevent rejection although these treatments are associated with an increased risk of cancer, especially skin cancer and lymphoma. The Pediatric Eczema Elective Registry (PEER) study was started in 2004 as part of the postmarketing commitments for the approval of pimecrolimus, according to the study background. David J. Margolis, M.D., … Continue reading →

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Asacol helps to prevent ulcerative colitis – Video

Posted: Published on February 18th, 2015

Asacol helps to prevent ulcerative colitis http://goo.gl/McmYWg. By: … Continue reading →

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A microbial metabolite of linoleic acid ameliorates intestinal inflammation

Posted: Published on February 18th, 2015

5 hours ago HYA, a microbial metabolite of linoleic acid, ameliorates intestinal barrier damage. Credit: Tanebe et al, The Journal of Biological Chemistry, DOI: 10.1074/jbc.M114.610733, FIG.3A Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. HYA is expected to be practically applied as a functional food. The results of this group's research were published in The Journal of Biological Chemistry as "A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway" DOI: 10.1074/jbc.M114.610733. IBD patients characteristically demonstrate increased expression of tumor necrosis factor receptor-2 and an upregulated inflammatory NF-B pathway. Professor Tanabe and his colleagues demonstrated that HYA binds to a G protein-coupled receptor (GPR40) and ameliorates intestinal epithelial barrier impairment in an intestinal epithelial cell line, Caco-2 cells; oral administration of HYA also alleviates colitis in mice. The physiological activity of gut microbial metabolites has recently attracted considerable attention. HYA may be … Continue reading →

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Fertility Clinic in Jordan Announces New Advanced IVF Program to Accelerate Industry-Leading Expertise

Posted: Published on February 18th, 2015

Chicago, IL (PRWEB) February 18, 2015 The fertility clinic of Dr. Rami Hamzeh is one of the few fertility centers to deliver the highest success rates in the Middle East. The fertility clinic in Jordan has announced an innovative IVF program to accelerate its industry-leading expertise in the field of reproductive medicine. It also marks the start of another incredible year for the VisitandCare.com partnered fertility provider. The IVF clinic in Jordan offers diagnosis and treatment of male and female infertility, including intra uterine Insemination (IUI), in vitro fertilization (IVF), and Gender Selection. Our partnership with exclusive fertility providers in Jordan creates a platform for unequalled contributions to fertility care and improvements in reproductive endocrinology. The IVF clinic of Dr. Rami Hamzeh is not only committed to delivering affordable treatment, but also an unyielding mission for new technologies, further distinguishing them from other clinics. When we partner with a provider, the goal is to improve the quality of life for our patients, stated Tolga Umar, CEO and Founder of VisitandCare.com. Advanced IVF Treatment in Jordan As a result of its continued partnership with VisitandCare.com, the fertility clinic in Jordan is reaching more intended parents who desire to build a family. … Continue reading →

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Autism treatment – NP Therapy – Video

Posted: Published on February 18th, 2015

Autism treatment - NP Therapy Dr. Anish Vaknalli, over the past 18 years has researched the use of specific Homeopathic remedies and essential, biochemical and neural supplements [NP-Ther... By: Anish Vaknalli … Continue reading →

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Pharmacologic treatments for the behavioral symptoms …

Posted: Published on February 18th, 2015

Abstract This review outlines pharmacologic treatments for the behavioral symptoms associated with autism spectrum disorders (ASDs) in children, adolescents, and adults. Symptom domains include repetitive and stereotyped behaviors, irritability and aggression, hyperactivity and inattention, and social impairment. Medications covered include serotonin reuptake inhibitors (SRIs), mirtazapine, antipsychotics, psychostimulants, atomoxetine, -2 agonists, D-cycloserine, and memantine. Overall, SRIs are less efficacious and more poorly tolerated in children with ASDs than in adults. Antipsychotics are the most efficacious drugs for the treatment of irritability in ASDs, and may be useful in the treatment of other symptoms. Psychostimulants demonstrate some benefit for the treatment of hyperactivity and inattention in individuals with ASDs, but are less efficacious and associated with more adverse effects compared with individuals with ADHD. D-cycloserine and memantine appear helpful in the treatment of social impairment, although further research is needed. Keywords: autism, autism spectrum disorder, autistic disorder, pervasive developmental disorder, treatment Esta revisin describe los tratamientos farmacolgicos para los sntomas conductuales asociados con los trastornos del espectro autista (TEA) en nios, adolescentes y adultos. Los sntomas incluyen conductas estereotipadas repetitivas, irritabilidad y agresividad, hiperactividad e inatencin, y deterioro social. Los frmacos incluyen inhibidores de la recaptura de serotonina (IRSs), mrtazapina, anti-psictcos, psicoestimulantes, … Continue reading →

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Sleep Apnea and its Role in Stroke Treatment – Video

Posted: Published on February 18th, 2015

Sleep Apnea and its Role in Stroke Treatment Many factors contribute to a patient being diagnosed with obstructive sleep apnea, including obesity. Research is looking at the condition's role in the trea... By: HCPLiveTV … Continue reading →

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Strain Review – DNA Genetics Kosher Tangie – Video

Posted: Published on February 18th, 2015

Strain Review - DNA Genetics Kosher Tangie She's been a champ for several rounds but it's time to retire her. A small farewell to the tastiest strain in my garden yet. "B-Roll" Kevin MacLeod (incompet... By: fregrowli … Continue reading →

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Mutants Genetics Gladiators Campaa Supra Estadio Samurai Sushi – Video

Posted: Published on February 18th, 2015

Mutants Genetics Gladiators Campaa Supra Estadio Samurai Sushi Jjaja Hoy Conoceras Otras Facetas De Mi Vos. By: Nosferatus Gamexx … Continue reading →

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Jill Hagenkord | A Decade of Direct Access Genetics: What have we learned? – Video

Posted: Published on February 18th, 2015

Jill Hagenkord | A Decade of Direct Access Genetics: What have we learned? 23andMe Chief Medical Officer, Jill Hagenkord, describes how their company is disrupting the healthcare industry by allowing people to access their own DNA. Genetic information is the basis... By: bigideasfest … Continue reading →

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