DNA methylation changes during cell differentiation webinar In this on-demand webinar, Dr Esteban Ballestar (PEBC-IDIBELL, Spain) provides an overall perspective on the connections between DNA methylation and other epigenetic marks and the interplay... By: Abcam … Continue reading →

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Taking inspiration from the way fossilized bones can preserve genetic material for hundreds of thousands of years, researchers at ETH Zurich have developed a "synthetic fossil" by writing digital information on DNA and then encapsulating it in a protective layer of glass. Most of our digital data is stored with technology that is designed to work in the short term, but which cant really stand the test of time. Standard hard disk drives wont last more than a few decades and are subject to damage from high temperatures, moisture, magnetic fields and mechanical failures. Even solid state drives, which perform better and are less susceptible to mechanical issues, will lose their data if they go unpowered for more than a few months. One interesting solution could be to store digital data using strands of DNA. As far-fetched as this may sound, there are a couple of very good reasons that make this an attractive proposition. Firstly, DNA can store information with a data density so high that it can be hard to fathom: a single living cell can contain millions of nucleobases and each can represent at least one bit of information, for a data density approaching one petabyte (million … Continue reading →

A global network of millions of genomes could be medicines next great advance. Availability: 1-2 years Technical standards that let DNA databases communicate. Your medical treatment could benefit from the experiences of millions of others. Noah is a six-year-old suffering from a disorder without a name. This year, his physicians will begin sending his genetic information across the Internet to see if theres anyone, anywhere, in the world like him. A match could make a difference. Noah is developmentally delayed, uses a walker, speaks only a few words. And hes getting sicker. MRIs show that his cerebellum is shrinking. His DNA was analyzed by medical geneticists at the Childrens Hospital of Eastern Ontario. Somewhere in the millions of As, Gs, Cs, and Ts is a misspelling, and maybe the clue to a treatment. But unless they find a second child with the same symptoms, and a similar DNA error, his doctors cant zero in on which mistake in Noahs genes is the crucial one. In January, programmers in Toronto began testing a system for trading genetic information with other hospitals. These facilities, in locations including Miami, Baltimore, and Cambridge, U.K., also treat children with so-called Mendelian disorders, which are caused … Continue reading →