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Miss., Calif research may lead to autism treatment

Posted: Published on February 4th, 2015

The Clarion-Ledger 2:55 p.m. CST February 3, 2015 From left, Dr. Kimberly Simpson, associate professor, Dr. Ryan Darling, assistant professor, Dr. Rick Lin, professor, and Dr. Yuegen "Jordan" Lu, assistant professor.(Photo: UMMC) Researchers in Mississippi and California say they have proven that the brain can be rewired which could translate into a treatment for autism. The study was published Monday in the Proceedings of the National Academy of Sciences. The report's co-author is Dr. Rick Lin, professor of neurobiology and anatomical sciences at the University of Mississippi Medical Center. The findings, for now, are limited to the study's test subjects rats. But the results have proven that these animals' brains can be rewired via intense auditory behavioral training, said Lin. The intricacies of a brain's wiring remains one of the largest puzzles before scientific researchers who have spent years to solve pieces of the complex mechanism. Yet for every question answered, more seem to appear. So when the UMMC team, working with scientists at the University of California in San Francisco, discovered the potential reset button, the discovery immediately drew questions of what the findings could mean for the future of autism treatments and, it is hoped, better outcomes. The … Continue reading →

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Stanford study ties immune cells to delayed onset of post-stroke dementia

Posted: Published on February 4th, 2015

A single stroke doubles a person's risk of developing dementia over the following decade, even when that person's mental ability is initially unaffected. Why this delayed deterioration occurs has been a mystery. Now, Stanford University School of Medicine investigators think they have discovered a major reason for it. In experiments using both mouse models of stroke and brain-tissue samples from humans, they linked the delayed onset of post-stroke dementia to the persistent presence, in the brain, of specialized immune cells that shouldn't be there at all. The discovery could potentially translate into ways of identifying people at risk for dementia, allowing physicians time to try to stave off the disease. Drugs that can disable these immune cells are already available. At roughly 800,000 new cases per year, stroke is the second-biggest cause of serious long-term disability in the United States, generating $74 billion annually in treatment and caretaking costs. Of the 7 million living stroke survivors nationwide, one-third either suffers from dementia, or will. In a study to be published Feb. 4 in The Journal of Neuroscience, a team directed by Marion Buckwalter, MD, PhD, assistant professor of neurosurgery and of neurology and neurosciences, examined several mouse models of stroke, … Continue reading →

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Campaign to highlight stroke symptoms launched throughout South West

Posted: Published on February 4th, 2015

A CAMPAIGN has been launched throughout the South West to educate and advise people how to cope if a stroke occurred. Public Health England (PHE) launched the annual Act FAST campaign on Monday, February 2, which highlights symptoms of stroke and mini strokes and encourages people to call 999 if they notice or experience them. Since the Act FAST campaign launched in 2009, an additional 38,600 people have got to hospital within the vital three-hour window meaning that stroke sufferers receive the immediate medical treatment required. Professor Julia Verne, Director of the Knowledge and Intelligence Team for Public Health England in the South West said: The impressive results from previous Act FAST campaigns show just how important it is that we continue to raise awareness of the symptoms of stroke. Highlighting the importance of treating mini strokes with the same urgency as strokes can also make a huge difference - around 10,000 strokes could be prevented annually if mini strokes were treated in time. Thats why the Act FAST campaign encourages people experiencing stroke-like symptoms to call 999. Nikki Hill, Deputy Director of External Affairs at the Stroke Association said: We know that sadly, far too many people dismiss their … Continue reading →

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Blood Test Aims to Detect Parkinson's in Early Stages

Posted: Published on February 4th, 2015

Randy Dotinga HealthDay Reporter Posted: Tuesday, February 3, 2015, 12:00 PM TUESDAY, Feb. 3, 2015 (HealthDay News) -- Researchers have developed a blood test that they say could help neurologists detect Parkinson's disease and track the illness as it progresses. "If successful, we expect our findings will translate into a valuable diagnostic tool for Parkinson's disease," said study co-author Judith Potashkin, professor of cellular and molecular pharmacology at Chicago Medical School, Rosalind Franklin University of Medicine and Science. An estimated 60,000 people in the United States are diagnosed with Parkinson's disease each year, according to the Parkinson's Disease Foundation. There is no cure for the disease, which can cause tremors and severely hamper movement. While medications can be helpful, the illness gets worse over time, and medications do not stop its progression. Physicians traditionally diagnosed Parkinson's by analyzing symptoms. Now, brain scans are available that provide insight, but scan images can still leave room for doubt, Potashkin said. In their new study, researchers say they've found two genetic markers that are 90 percent effective at indicating the presence of Parkinson's disease. The markers are related to how the body processes glucose (blood sugar) and insulin, said study lead author Jose … Continue reading →

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Neurologists Find Movement Tracking Device Helps Assess Severity of Parkinson's Disease

Posted: Published on February 4th, 2015

A device that measures movement and balance can effectively help assess and track the progression of Parkinson's disease, even when medications are used to reduce Parkinson's symptoms, UT Southwestern Medical Center research found. Researchers found that the APDM Mobility Lab -- a portable set of sensors that track gait, balance and other movement -- can effectively help clinicians estimate the depth and severity of the neurological disorder in affected individuals, even while patients are taking medications to control trembling and other symptoms. The findings appear in the Journal of the Neurological Sciences. "Objective assessment tools for Parkinson's disease are needed to accelerate progress in developing effective therapies," said Dr. Richard Dewey, Jr., Professor of Neurology and Neurotherapeutics, Clinical Director of the Clinical Center for Movement Disorders at UT Southwestern, and senior author of the study. "We might be able to actually measure the patient's progress or regression thoroughly and objectively." Parkinson's disease is a progressive neurological disorder characterized by trembling in the hands, arms, legs, jaw, and face; rigidity or stiffness; and balance and coordination difficulties. According to the Parkinson's Disease Foundation, more than 10 million people worldwide and more than 1 million in the U.S. live with the disease. … Continue reading →

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Lysosomal Therapeutics raises $20M Series A from Sanofi, Lilly and Roche for Parkinsons drug

Posted: Published on February 4th, 2015

February 3, 2015 8:03 pm by Meghana Keshavan | 0 Comments MedCity News Cambridge biotech Lysosomal Therapeutics just raised a whopping $20 million Series A for its small molecule Parkinsons disease treatment, with backing from the venture arms of several big pharma Sanofi, Lilly and Roche. The company will use the proceeds of this round to optimize its main compound, and preclinically develop a glucocerebrosidase lysosomal enzyme activator to treat Parkinsons. The funding is also supporting a biomarker initiative, which already has funding from the Michael J. Fox Foundation for Parkinsons Research, that will helpselect patients for clinical trials and patient selection. This biomarker project will help researchers find the geneticlinks between other lysosomal storage disorders and neurodegenerative diseases, the company said in a statement. The round includes Atlas Venture, Hatteras Venture Partners, Lilly Ventures, Sanofi-Genzyme BIoVentures, Roche Venture Fund, Partners Innovation Fund and several of the original angels such as Orion Equity Partners, and LTI co-founders Henri Termeer and Bob Carpenter.The company brought in a $4.8 million seed round just last May, indicative of some serious interest in this approach to neurological drugs. Get our daily newsletter or follow us. Please enter your email below: Originally posted here: Lysosomal … Continue reading →

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Making Treatment and Lifestyle DecisionsNMSS – Video

Posted: Published on February 4th, 2015

Making Treatment and Lifestyle DecisionsNMSS DC MS Empowerment Group Making Treatment and Lifestyle Decisions: Thinking about the Benefits and Risks of Different MS Therapies 2013 National Multiple Sc... By: Victor Sparrow … Continue reading →

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Stem Cell Treatment Can Cure Many Ailments – Video

Posted: Published on February 4th, 2015

Stem Cell Treatment Can Cure Many Ailments Advances in stem cell research have led to innovative new treatments for those suffering from autoimmune or orthopedic conditions. If you are suffering from Crohn's disease, spine disease,... By: Mississippi Stem Cell Treatment Center … Continue reading →

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McCloskey Speaker Series: Ezekiel Emanuel – Video

Posted: Published on February 4th, 2015

McCloskey Speaker Series: Ezekiel Emanuel The Aspen Institute, 2009. The Ethics of Stem Cell Research Featuring Ezekiel Emanuel in conversation with Walter Isaacson, President and CEO of the Aspen ... By: The Aspen Institute … Continue reading →

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Eunice Kennedy Shriver National Institute of Child Health and Human Development Funds Molecular Study at Upstate …

Posted: Published on February 4th, 2015

Contact Information Available for logged-in reporters only Newswise A molecular study at Upstate Medical University that could have broad implications for stem cell research, developmental biology and the study of human diseases has received $161,000 in funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The two-year study is led by Francesca Pignoni, Ph.D., associate professor of ophthalmology, biochemistry and molecular biology and neuroscience and physiology, in her laboratory at Upstates Neuroscience Research Building. Using the Drosophila fly model, Pignoni is studying how a new protein discovered in her laboratory to be necessary and sufficient for the self-renewal of the germ-line stem cell in the fly ovaryfunctions at the molecular level. During reproduction, the germ-line stem cell allows genetic material to be passed to progeny. The information gained from this portion of the study will advance our understanding of stem cell maintenance over an organisms lifetime and lead to a longer-term project, said Pignoni. Our discovery will influence future stem cell research, and may have implications for fertility studies, but a fun part of discovering the function of a new factor is that we get to name it, and we have chosen Lilipod, or Lili … Continue reading →

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