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Epigenetic drug boosts chemotherapy's efficacy in some lung cancers

Posted: Published on January 29th, 2015

IMAGE:This is Carla Kim, PhD, of the Boston Children's Hospital Stem Cell Research Program. view more Credit: Boston Children's Hospital BOSTON (January 28, 2015) -- An existing drug may help some patients with non-small-cell lung cancer (NSCLC) whose tumors have become resistant to chemotherapy, finds a study from Boston Children's Hospital and the Dana-Farber Cancer Institute (DFCI). The findings, in human cancer cells and in mice, suggest a window of vulnerability in NSCLC, the leading cause of cancer-related deaths worldwide.1 The work was published online today by the journal Nature. NSCLC is a highly genetically complex cancer with many different subtypes, each bearing different mutations. In two common subtypes that do not respond to standard chemotherapy--tumors with BRG1 or EGFR mutations--the researchers increased the effectiveness of etoposide, a common chemotherapy agent, by adding an epigenetic therapy already in clinical testing. Conversely, when the same epigenetic therapy (inhibition of an enzyme known as EZH2) was added to certain tumors without BRG1 and EGFR mutations, the tumors become more resistant to chemotherapy. Together, the findings advance the idea of individualized, "precision medicine" in cancer, incorporating epigenetic therapy guided by tumor genetic testing. The study also suggests that genetic tumor testing should screen … Continue reading

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3 days before Panama trip for MS Stem Cell Treatment – Video

Posted: Published on January 29th, 2015

3 days before Panama trip for MS Stem Cell Treatment Wanted to document my current mobility before leaving for Panama so I can track my progress after treatment. By: Amy Madel … Continue reading

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Hope for Eczema: New Treatment Developments Part 1 – Video

Posted: Published on January 29th, 2015

Hope for Eczema: New Treatment Developments Part 1 By: NationalEczema … Continue reading

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Tampa dermatologists ongoing clinical trial for eczema now accepting patients over 65

Posted: Published on January 29th, 2015

As his clinical trials for eczema continue, Tampa dermatologist Dr. Seth Forman has been given the go-ahead to offer patients 65 years and over an opportunity to receive what the dermatologist is describing as a one-of-a-kind, breakthrough treatment for sufferers of the skin condition. Having already treated several eczema patients, Dr. Forman hopes that the eligibility extending to a broader audience for treatment will aid in the progression of the trials and continue to produce positive results. In addition, the expansion will make trials nearly available to anyone over the age of 18. Its important that everyone has an opportunity to receive treatment, says the Tampa dermatologist. This will only help us to further determine the effectiveness of the trials. Also known as atopic dermatitis, eczema is a skin condition characterized by irritated skin due to the release of inflammatory chemicals in the body. Common symptoms include a combination of itchy, dry and red patchy skin on areas of the body including the face, hands and neck. Patients enrolled in the trial will receive subcutaneous (injected under the skin) medication at no cost, as well as free lab tests and exams by the Tampa dermatologist and his office. In addition, … Continue reading

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Telomere-lengthening procedure turns clock back years in human cells

Posted: Published on January 29th, 2015

Researchers at the Stanford University School of Medicine have developed a new procedure to increase the length of human telomeres. This increases the number of times cells are able to divide, essentially making the cells many years younger. This not only has useful applications for laboratory work, but may point the way to treating various age-related disorders or even muscular dystrophy. Telomeres are the caps at the ends of our chromosomes that protect the DNA code of the genome. Linked to aging and disease, they are 8,000 to 10,000 nucleotides long in young people, but this decreases as we age (a nucleotide is an organic molecule that is a subunit of nucleic acids DNA and RNA). The researchers have found a way to lengthen a telomere by 1,000 nucleotides, which Dr. Helen Brau, professor of microbiology and immunology at Stanford, says is the equivalent of "many years of human life." Telomeres shorten each time a cell divides and at a certain point, when they reach a critical length, the cell can no longer divide and will die. Their limited lifespan means that growing cells in laboratories can be tricky, given there can only be so many cell doublings before they … Continue reading

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Novel compound switches off epilepsy development

Posted: Published on January 29th, 2015

Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have found that a novel compound they discovered helps curtail the onset and progression of temporal lobe epilepsy. The finding, which may contribute to the development of anti-epileptic therapies, is published online in the journal PLOS ONE. In temporal lobe epilepsy, seizures arise in the hippocampus and other structures of the limbic system located in the temporal lobe when a cascade of molecular and cellular events results in aberrant brain wiring. (The limbic system is the region of the brain associated with memory and emotions.) Seizures reflect uncontrolled electrical brain activity. The period between a brain injury and the onset of seizures, called epileptogenesis, is a "silent" period because this brain abnormality cannot be detected by current neurological exams or electroencephalography (EEG). Temporal lobe epilepsy (TLE), or limbic epilepsy, is a common adult epileptic disorder characterized by spontaneous recurrent seizures that may also spread to other brain regions, triggering secondary severe generalized seizures. Aside from neurosurgery, which benefits only a small population of TLE patients, there are no other effective treatments or preventive strategies. Working in a mouse model, the research team led by Drs. Nicolas Bazan, Boyd Professor … Continue reading

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LSU Health New Orleans research finds novel compound switches off epilepsy development

Posted: Published on January 29th, 2015

New Orleans, LA - Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have found that a novel compound they discovered helps curtail the onset and progression of temporal lobe epilepsy. The finding, which may contribute to the development of anti-epileptic therapies, is published online in the journal PLOS ONE, available at http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116543. In temporal lobe epilepsy, seizures arise in the hippocampus and other structures of the limbic system located in the temporal lobe when a cascade of molecular and cellular events results in aberrant brain wiring. (The limbic system is the region of the brain associated with memory and emotions.) Seizures reflect uncontrolled electrical brain activity. The period between a brain injury and the onset of seizures, called epileptogenesis, is a "silent" period because this brain abnormality cannot be detected by current neurological exams or electroencephalography (EEG). Temporal lobe epilepsy (TLE), or limbic epilepsy, is a common adult epileptic disorder characterized by spontaneous recurrent seizures that may also spread to other brain regions, triggering secondary severe generalized seizures. Aside from neurosurgery, which benefits only a small population of TLE patients, there are no other effective treatments or preventive strategies. Working in a mouse model, the research team … Continue reading

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Heat Stroke: Get the Facts on First Aid and Treatment

Posted: Published on January 29th, 2015

Heat stroke facts Heat stroke is a form of hyperthermia in which the body temperature is elevated dramatically. Heat stroke is a medical emergency and can be fatal if not promptly and properly treated. Cooling the victim is a critical step in the treatment of heat stroke. Always notify emergency services immediately if heat stroke is suspected. The most important measures to prevent heat strokes are to avoid becoming dehydrated and to avoid vigorous physical activities in hot and humid weather. Infants, the elderly, athletes, and outdoor workers are the groups at greatest risk for heat stroke. What is, and who is at risk for heat stroke? Heat stroke is a form of hyperthermia or heat-related illness, an abnormally elevated body temperature with accompanying physical symptoms including changes in the nervous system function. Unlike heat cramps and heat exhaustion, two other forms of hyperthermia that are less severe, heat stroke is a true medical emergency that is often fatal if not properly and promptly treated. Heat stroke is also sometimes referred to as heatstroke or sun stroke. Severe hyperthermia is defined as a body temperature of 104 F (40 C) or higher. The body normally generates heat as a result … Continue reading

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Coping with stroke, stroke symptom, or stroke treatment …

Posted: Published on January 29th, 2015

Stroke Symptoms These stroke symptoms usually strike suddenly: The only possible warning sign that stroke might be coming is a transient ischemic attack (TIA), in which the patient experiences some of the early effects of a stroke for up to an hour. As one in three people who suffer a TIA eventually have a stroke, it is crucial to see a doctor as soon as possible after a TIA. There are two types of stroke: in one case the brain suddenly receives too little blood (an ischemic stroke) and in the other it receives too much (hemorrhagic). About 80% are ischemic, caused by clots or other particles blocking arteries that supply blood to the brain. As brain cells are deprived of oxygen and nutrients, they may begin to die within minutes. (Source: http://www.mayoclinic.com/health/stroke) Because of the damage it can do throughout the body, a Stroke can severely weaken or even disable entire areas of the body. Hand and wrist function are often lost or diminished, usually on one side of the body, and the resulting change in lifestyle can be devastating: The patient suddenly may need assistance just to eat, groom, dress, bathe, work, or enjoy leisure activities. If you … Continue reading

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Ischemic Stroke Treatment & Management – Medscape Reference

Posted: Published on January 29th, 2015

Services and Web Sites Covered This policy describes what information may be collected about you when you use the services made available through the WebMD Health Professional Network (as defined below), how this information may be used, how you can control how your information is used and what precautions are taken against unauthorized access or use of your information. The services made available through the WebMD Health Professional Network may be provided in a variety of mediums and devices now known or hereinafter developed including mobile applications, and include without limitation news, reference tools and applications, sponsored programming, personalized content, continuing medical education, communication tools and discussion boards (collectively, the "Services"). You should read the privacy policy of each website that you visit after you leave any of the WebMD Health Professional Network websites. We are not responsible for how other websites treat your privacy once you leave one of our websites. The WebMD Health Professional Network is comprised of several websites including medscape.com, medscape.org, medscape.fr and medscapedeutschland.de (referred to collectively as the "Professional Sites"), including any mobile optimized versions of the Professional Sites and the Medscape Mobile Device Application ("Medscape Mobile"). These properties are owned and operated by our … Continue reading

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