The 2011 Fukushima disaster was a stark reminder of the continuing dangers posed by nuclear fallout, highlighting the need for an approved drug that can be taken after radiation exposure to protect against organ injury and death. A study published by Cell Press on January 22nd in Chemistry & Biology identifies a drug candidate called DBIBB that increases the survival of mice suffering from radiation syndrome, even when treatment started three days after radiation exposure. The findings suggest that DBIBB shows promise for becoming the first drug capable of treating acute radiation syndrome caused by the high levels of radiation released by nuclear explosions. "The 21st Century has presented humankind with unforeseen challenges, including the possibility of radiation terrorism," said senior study author Gbor Tigyi, a professor of physiology at the University of Tennessee Health Science Center (UTHSC). "We hope that the scientific community and our efforts will provide protection through medical countermeasures against the harmful effects of ionizing radiation and also help humans to benefit from the useful effects of nuclear technology." Nuclear explosions can expose humans to high levels of ionizing radiation, which can cause cell death and organ injury due to DNA damage. Although some agents tested … Continue reading
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