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New technique could revolutionize stem-cell transplants

Posted: Published on January 21st, 2015

CTV.ca News Staff Published Monday, November 30, 2009 10:06AM EST Last Updated Saturday, May 19, 2012 12:22AM EDT Montreal researchers are taking part in what could become a breakthrough in stem cell transplants, by leading the first transplant of a mismatched donor. A 28-year-old father-to-be who has Ewing sarcoma is about to become the first person in North America to get a transplant from a mismatched donor. The patient, Andrew Willette, needs the transplant to fight his cancer, but no one in his family is an appropriate match. So he will be using cells from his sister, who is only a partial match. Usually, such transplants fail. That's because patients usually reject and attack the foreign donor cells. The ensuing response can kill the patient, or lead to infections or relapses. But, the technique pioneered in a Montreal lab by Dr. Denis-Claude Roy of the Maisonneuve-Rosemont Hospital could change that. Roy explains that his research team developed a new approach that preserves the cells that fight infection and disease while eliminating the cells that reject donor cells. "We are letting Mother Nature decide which cells are going to react," he told CTV's Canada AM Monday morning. Roy explains that the … Continue reading

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New York's Program for Jewish Genetic Health and Montefiore Health System Partner to Offer Subsidized Genetic Testing …

Posted: Published on January 21st, 2015

Contact Information Available for logged-in reporters only Newswise NEW YORK, January 21, 2015 New York metropolitan area Ashkenazi Jewish women and men aged 25 and older can now opt to undergo testing for the three common Ashkenazi Jewish BRCA founder mutations at a fraction of the commercial price, thanks to a new, philanthropy-based initiative from the Program for Jewish Genetic Health (PJGH), a not-for-profit organization affiliated with Yeshiva University and Albert Einstein College of Medicine (Einstein), in conjunction with Montefiore Health System (Montefiore). This initiative, the first of its kind in the United States, makes this testing available to all Ashkenazi Jewish individuals, regardless of their BRCA-related cancer histories or their insurance/financial situations, both of which have been barriers to date. Most insurance companies currently require people to already have had family members with cancer if they want to be covered for BRCA genetic testing, said Susan Klugman, MD, medical director for the Program for Jewish Genetic Health, director of the division of reproductive genetics at Montefiore, and professor of clinical obstetrics & gynecology and women's health at Einstein. We at the Program for Jewish Genetic Health are not willing to wait for that. Background Approximately 1 in 40 individuals … Continue reading

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USC neuroscientists lead global ENIGMA consortium to crack brain's genetic code

Posted: Published on January 21st, 2015

Global research alliance ENIGMA finds 8 common gene mutations leading to brain age in over 30,000 brain scans that may some day unlock mysteries of Alzheimer's, autism and other neurological disorders LOS ANGELES -- In the largest collaborative study of the brain to date, researchers from the Keck School of Medicine of the University of Southern California (USC) led a global consortium of 190 institutions to identify eight common genetic mutations that appear to age the brain an average of three years. The discovery could lead to targeted therapies and interventions for Alzheimer's disease, autism and other neurological conditions. An international team of roughly 300 scientists known as the Enhancing Neuro Imaging Genetics through Meta Analysis (ENIGMA) Network pooled brain scans and genetic data worldwide to pinpoint genes that enhance or break down key brain regions in people from 33 countries. This is the first high-profile study since the National Institutes of Health (NIH) launched its Big Data to Knowledge (BD2K) centers of excellence in 2014. The research was published Wednesday, Jan. 21, in the peer-reviewed journal Nature. "ENIGMA's scientists screen brain scans and genomes worldwide for factors that help or harm the brain -- this crowd-sourcing and sheer wealth … Continue reading

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"She’s Happy" RMG’s next Stem Cell Miracle – Video

Posted: Published on January 21st, 2015

"She's Happy" RMG's next Stem Cell Miracle Meet Mary Taylor, she was blind for four years from wet and dry Macular Degeneration. Her son Richard, was a previous patient of Regenerative Medical Group, as he received treatment for his... By: iManifestart … Continue reading

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What is the current development in nanomedicine for clinical diagnosis & treatment?

Posted: Published on January 21st, 2015

IMAGE:This is the cover for Bio-inspired Nanomaterials and Applications. view more Credit: World Scientific, 2015 Nanomedicine has been developing rapidly in recent years, particularly in the development of novel nano tools for medical diagnosis and treatment. For instance, a new trend is becoming prevalent in developing nanosystems for simultaneous tumor diagnosis and therapy. This requires high versatility of the nanocarriers with multiple functionalities of cell targeting, drug storage, optical imaging, and effective means of treatment such as magnetic and photothermal hyperthermia, photodynamic therapy, and drug release via various intelligent mechanisms (pH, temperature, and biochemical variations in the tumor environment). A new terminology "theranosics" has been frequently used and applied in pre-clinical research and trials. A nanosystem can simultaneously achieve both cell targeted in vivo imaging and photothermal treatment of cancer. While achieving concurrent high spatial and temporal resolution of the lesions via cell targeting; special non-evasive treatments are implemented at the same time by various means, such as localized drug release, hyperthermia, and photo-thermal therapy. Inspired by these challenging problems in biomedical fields, the development of the nanotechnologies will be the key in addressing some of the critical issues in medicine, especially in early cancer diagnosis and treatment. In this … Continue reading

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Nutech Mediworld – Pioneering human embryonic stem cell therapy – Video

Posted: Published on January 21st, 2015

Nutech Mediworld - Pioneering human embryonic stem cell therapy An audio visual that features patients suffering from conditions considered incurable or terminal. And how they experienced significant improvement with human embryonic stem cell therapy at... By: Resonance Consulting … Continue reading

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MS patients given stem cells improve

Posted: Published on January 21st, 2015

Stem cell therapy may have helped patients with a form of multiple sclerosis, according to a preliminary study. Patients with relapsing-remitting multiple sclerosis showed signs of improvement after being treated with their own, or autologous "nonmyeloablative hematopoietic stem cells," a class of blood-forming stem cells, the study found. It was published Tuesday in the Journal of the American Medical Association. Half, or 41 patients, tested two years after treatment experienced significant improvement on the Expanded Disability Status Scale, a measure of disability. And of patients tested at 4 years, 23, or 64 percent, showed significant improvement. Four-year relapse-free survival was 80 percent and progression-free survival was 87 percent. "To our knowledge, this is the first report of significant and sustained improvement in the EDSS score following any treatment for MS," stated the study. It was led by Dr. Richard K. Burt of Northwestern University in Chicago. However, only limited conclusions can be drawn from the uncontrolled study, according to scientists who examined the results. While the therapy was associated with improvement, the stem cell transplant may not have been key. A conditioning regimen that partially depleted the stem cells before transplantation may have been responsible, said Dr. Stephen L. Hauser … Continue reading

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Does gestational diabetes affect the therapeutic potential of umbilical cord-derived stem cells?

Posted: Published on January 21st, 2015

IMAGE:Stem Cells and Development is an authoritative peer-reviewed journal published 24 times per year in print and online. The journal is dedicated to communication and objective analysis of developments in... view more Credit: Mary Ann Liebert, Inc., publishers New Rochelle, NY, January 20, 2015-- Multipotent cells isolated from the human umbilical cord, called mesenchymal stromal cells (hUC-MSCs) have shown promise for use in cell therapy to treat a variety of human diseases. However, intriguing new evidence shows that hUC-MSCs isolated from women with gestational diabetes demonstrate premature aging, poorer cell growth, and altered metabolic function, as reported in an article in Stem Cells and Development, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Stem Cells and Development website until February 17th, 2015. Jooyeon Kim and coauthors from University of Ulsan College of Medicine, Kyung Hee University College of Medicine, and Seoul National University Bundang Hospital, Seoul, Korea, compared the growth and viability characteristics of hUC-MSCs from the umbilical cords of pregnant women with and without gestational diabetes. They evaluated cell growth, cellular senescence, mitochondrial function-related gene expression as a measure of metabolic activity, and the stem cells' ability to differentiate into various … Continue reading

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Bossier Sheriff Deputies help one of their own

Posted: Published on January 21st, 2015

70% of those who need a Stem Cell or Bone Marrow Transplant, don't have a matching donor. They are relying on a complete stranger to help save their life. It could be you. LifeShare Blood Centershopes to change that percentage. Today from 12pm-6pm, LifeShare and the Bossier Sheriff's Department are joining forces in a Blood Drive/Bone Marrow Registration event. It all takes place at the Bossier Sheriff Substation, 2510 Viking Drive (in Bossier City). The Bossier Sheriff's Department is getting involved because one of their own is in need of someone who is a match for Bone Marrow. Sgt. Barrett Lovell (33), has been aggressively fighting cancer for the past three months. Lovell works in the Corrections Division for the Bossier Sheriff's Office, and was diagnosed with Acute Myeloid Leukemia. He's been undergoing chemotherapy and multiple blood transfusions, and needs a stem cell transplant. View post: Bossier Sheriff Deputies help one of their own … Continue reading

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St Albans leisure centre hosts recruitment event this evening to find donors for stem cell transplants

Posted: Published on January 21st, 2015

12:02 20 January 2015 Madeleine Burton A stem cell donor recruitment day to find lifesavers for people suffering with blood cancers is being held at Westminster Lodge Leisure Centre today. Email this article to a friend To send a link to this page you must be logged in. The recruitment day, which runs from 5pm to 8.30pm, has been organised by the Everyone Active team at Westminster Lodge in support of their colleague Chris Spencer who underwent a stem cell transplant through the Anthony Nolan charity after being diagnosed with bone marrow failure in June 2013. Anyone aged 16-30 and in good health can become a donor and to register, participants just need to drop into Westminster Lodge on the day, fill in a short medical form and provide a saliva sample. Once registered, donors will remain on the register until the age of 60, unless they chose to be removed from it sooner. Everyone Active general manager, Lesley Garner, said: Were looking forward to hosting a recruitment day to raise awareness and help support Anthony Nolans invaluable work, For thousands of people with blood cancers such as leukaemia, their only hope of survival is a donation of healthy stem … Continue reading

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