SF State-led team's software determines drugs' effectiveness in treating schistosomiasis For decades, scientists around the world have worked to develop a treatment for schistosomiasis, a debilitating water-born parasite that affects more than 200 million people worldwide. To aid this research, Rahul Singh, professor of computer science at San Francisco State University, has developed software that solves the key challenge of quantitatively assessing the impact of a drug on the parasite. Singh and his team recently completed and made public the Quantal Dose Response Calculator (QDREC), software that analyzes images showing the effects of potential drugs on parasites and quantifies their effectiveness. A description of the software was published online in Bioinformatics (Oxford University Press) on Dec. 24. QDREC is designed to streamline the screening stage of the drug-discovery process, during which possible drugs are first identified. Traditionally, after introducing a chemical compound to a parasite, a scientist is required to meticulously document and analyze changes. The subjective and low-throughput nature of this process -- requiring highly trained scientists to study, one by one, the effects of a potential drug -- is one of the major barriers to breakthroughs, Singh said. "You are doomed to only a trickle of advancements," he … Continue reading
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