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Hero dad from Cam conquers Everest without leaving Gloucestershire

Posted: Published on January 7th, 2015

First published in News Last updated by Stuart Rust, reporter covering Dursley, Cam, Sharpness, Slimbridge, Kingscote, Stone, Coaley, Uley, Woodford, North Nibley, Stinchcombe and Cambridge A HEROIC father from Slimbridge climbed the height of the worlds tallest mountain and raised 21,000 for a life-changing operation for his three-year-old daughter with cerebral palsy. James Bottger, 37, walked up and down Robinswood Hill, in Gloucester, 75 times, the equivalent distance one would tackle if climbing Mount Everest. The money he raised means the Bottger family now have the 60,000 they require to travel to America with their daughter for surgery and physiotherapy that may allow her to walk, something she is unable to do due to her condition. Mr Bottger lives in St John's Road, Slimbridge, with his wife Kate and two daughters Charlotte and four-month old Harriet. Charlotte was born 10 weeks premature and, as a result of the brain-damage she incurred, was diagnosed as having quadriplegic cerebral palsy at 18 months of age. Increased spasticity - stiffness in the muscles of the arms legs and backs - has rendered Charlotte incapable of walking, as well as causing a significant amount of pain and a general reduction of motor functions. St … Continue reading

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Hero dad from Slimbridge conquers Everest without leaving Gloucestershire

Posted: Published on January 7th, 2015

First published in News Last updated by Stuart Rust, reporter covering Dursley, Cam, Sharpness, Slimbridge, Kingscote, Stone, Coaley, Uley, Woodford, North Nibley, Stinchcombe and Cambridge A HEROIC father from Slimbridge climbed the height of the worlds tallest mountain and raised 21,000 for a life-changing operation for his three-year-old daughter with cerebral palsy. James Bottger, 37, walked up and down Robinswood Hill, in Gloucester, 75 times, the equivalent distance one would tackle if climbing Mount Everest. The money he raised means the Bottger family now have the 60,000 they require to travel to America with their daughter for surgery and physiotherapy that may allow her to walk, something she is unable to do due to her condition. Mr Bottger lives in St John's Road, Slimbridge, with his wife Kate and two daughters Charlotte and four-month old Harriet. Charlotte was born 10 weeks premature and, as a result of the brain-damage she incurred, was diagnosed as having quadriplegic cerebral palsy at 18 months of age. Increased spasticity - stiffness in the muscles of the arms legs and backs - has rendered Charlotte incapable of walking, as well as causing a significant amount of pain and a general reduction of motor functions. St … Continue reading

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Brain Damage Rare When Newborn Jaundice Is Treated, Study Finds

Posted: Published on January 7th, 2015

MONDAY, Jan. 5, 2015 (HealthDay News) -- Newborns with significant jaundice are not likely to develop a rare and life-threatening type of cerebral palsy if American Academy of Pediatrics' treatment guidelines are followed, according to a new study. Jaundice is yellowing of the eyes and skin due to high levels of the liver-produced pigment bilirubin. In most cases, jaundice develops among newborns because their liver is too immature to break down the pigment quickly enough. Usually, this condition resolves without treatment. Some babies, however, must receive phototherapy. Exposure to special lights changes bilirubin into a compound that can be excreted from the body, according to the researchers. If phototherapy fails, a procedure called exchange transfusion may be required. During this invasive procedure, the infant's blood is replaced with donor blood. Recommendations for exchange transfusions are based on bilirubin level, the age of the infant and other risk factors for brain damage. Exchange transfusion isn't without risk. Potential complications from the treatment include blood clots, blood pressure instability, bleeding and changes in blood chemistry, according to the researchers. High bilirubin levels are also risky. They've been associated with a serious form of cerebral palsy called kernicterus. In order to investigate this … Continue reading

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Hyperbaric oxygen therapy for autism, brain injury growing despite evidence of efficacy

Posted: Published on January 7th, 2015

Published January 06, 2015 Lee Frost spent three months in 2013 taking her son Callum for treatment in a high-pressure oxygen chamber, in hopes it would help his severe autism. Ms. Frost, frustrated by the lack of approved treatments for her son, discovered hyperbaric oxygen therapy through online research. Callums ability to communicate had been limited to screaming tantrums, biting and slapping, she recalls. After receiving the therapy, which involves inhaling pure oxygen for 75 minutes at a time, Callum, now 5, is able to speak in sentences and dress himself in the morning before kindergarten, Ms. Frost says. His treatment also included dietary changes. He still has a way to go, but the child he is today is a different child, says Ms. Frost, who lives in White Rock, British Columbia, in Canada. Ms. Frost is one of the growing number of people who have pursued hyperbaric oxygen therapy, or HBOT, for uses that mainstream doctors, government regulators and patient advocates say are unproven. In a 2013 consumer alert, the U.S. Food and Drug Administration warned that hyperbaric oxygen therapy has not been clinically proven to cure or be effective in the treatment of cancer, autism, or diabetes despite … Continue reading

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Germany's Angela Merkel needs a dressing down, not the red carpet treatment

Posted: Published on January 7th, 2015

Recent data point to an even wider deficit last year. Were it not for this trade imbalance with Europe, Britain might actually be a surplus economy, such is our balance of payments position with other Anglo-Saxon economies. More than a third of this deficit is accounted for by Germany, which dwarfs the next largest surplus economy, China, and as a consequence is fast becoming Britains biggest creditor. Some of the reasons for this success are obvious enough. Germany makes some of the most desirable cars, vacuum cleaners, washing machines and other consumer goods in the world. It also makes some of the best machine tools, construction materials and so on. Yet there is a less benign reason, too it is also because of mercantilist policy in Germany, which prioritises exports over domestic demand, and because of extraordinarily accommodative demand management in Britain. Neither policy is ultimately sustainable. Britain cannot forever keep supporting European demand through credit-fuelled monetary and fiscal stimulus. Nor can Germany indefinitely keep clocking up charges against its main export markets. Eventually debtors will find a way of defaulting, or otherwise escaping their obligations. In the meantime, Britain grows, providing Germany with abundant export markets, even as Europe … Continue reading

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Patients shocked to find hormone therapy office under investigation

Posted: Published on January 7th, 2015

LEES SUMMIT, Mo. The Missouri Department of Health and Senior Services is investigating Body Renew Medical Group in Lees Summit. Staff at Body Renew Medical Group wouldnt do an interview with FOX 4 on Tuesday about the investigation, but said they were dealing with technicality. Several patients said they werent notified of their appointment being cancelled, but showed up and were told they couldnt receive their hormone injections. I called them and I made an appointment and I just said is there anything I need to know before I come in, can I get my shots, said Jennifer Matthies, who has been a patient at the medical group for several months. They were like were not going to be able to do shots today. Matthies said going to the Body Renew Medical Group has dramatically changed her life for the better and she hopes she can start getting hormones from them again soon. The Missouri Department of Health and Senior Services couldnt tell FOX 4 why Body Renew Medical Group is being investigated. Its spokesman said in a statement, There is an ongoing investigation involving Body Renew Medical Group, and due to state law the department cannot provide further information … Continue reading

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The Berlin patient, first and only person 'cured' of HIV, speaks out

Posted: Published on January 7th, 2015

Date: January 6, 2015 Source: Mary Ann Liebert, Inc., Publishers Summary: Timothy Ray Brown, long known only as the "Berlin Patient" had HIV for 12 years before he became the first person in the world to be cured of the infection following a stem cell transplant in 2007. He recalls his many years of illness, a series of difficult decisions, and his long road to recovery in a new first-person account. Timothy Ray Brown, long known only as the "Berlin Patient" had HIV for 12 years before he became the first person in the world to be cured of the infection following a stem cell transplant in 2007. He recalls his many years of illness, a series of difficult decisions, and his long road to recovery in the first-person account, "I Am the Berlin Patient: A Personal Reflection," published in AIDS Research and Human Retroviruses, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Brown's Commentary describes the bold experiment of using a stem cell donor who was naturally resistant to HIV infection to treat the acute myeloid leukemia (AML) diagnosed 10 years after he became HIV-positive. The stem cell donor had a specific genetic mutation called CCR5 Delta 32 … Continue reading

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Circadian rhythms regulate skin stem cell metabolism and expansion, UCI study finds

Posted: Published on January 7th, 2015

Body clock protects cells from metabolism-generated oxygen radical damage during division Irvine, Calif., Jan. 6, 2015 -- UC Irvine scientists studying the role of circadian rhythms in skin stem cells found that this clock plays a key role in coordinating daily metabolic cycles and cell division. Their research, which appears Jan. 6 in Cell Reports, shows for the first time how the body's intrinsic day-night cycles protect and nurture stem cell differentiation. Furthermore, this work offers novel insights into a mechanism whereby an out of synch circadian clock can contribute to accelerated skin aging and cancers. Bogi Andersen, professor of biological chemistry and medicine, and Enrico Gratton, professor of biomedical engineering, focused their efforts on the epidermis, the outermost protective layer of the skin that is maintained and healed by long-lived stem cells. While the role of the circadian clock in processes such as sleep, feeding behavior and metabolism linked to feeding and fasting are well known, much less is known about whether the circadian clock also regulates stem cell function. The researchers used novel two-photon excitation and fluorescence lifetime imaging microscopy in Laboratory of Fluorescence Dynamics in UCI's Department of Biomedical Engineering to make sensitive and quantitative measurements of … Continue reading

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UC Davis presents 2015 Benjamin Highman Lecture on genomic medicine

Posted: Published on January 7th, 2015

(PRWEB) January 06, 2015 Sequencing the genomes, or entire DNA codes, of individuals to better diagnose and treat disease is a burgeoning area of research. From identifying specific genetic mistakes highly associated with certain cancers to applying effective treatments to mitigate a wayward genes effects, personalized genomic medicine is increasingly finding its way into patient care. Harnessing the power of whole genome analysis and further defining the role of pathologists in this new era of medicine is the topic of the 2015 Benjamin Highman Lecture, sponsored by the Department of Pathology and Laboratory Medicine at UC Davis Health System. The lecture, entitled Moving to Genomic Medicine, will be held from 5 p.m. to 6 p.m. on Thursday, Jan. 22 at the Education Building, 4610 X Street in auditorium #2222 in Sacramento. A reception will follow the presentation. Participants can register at Eventbrite. The lecture will be presented by Debra G. B. Leonard, a leading expert in molecular pathology and genomic medicine and in applying genomic information for diagnosis and treatment of human diseases, including inherited disorders, cancers and infectious diseases. During her presentation, Leonard will highlight the current applications for genomics and describe the various online genomic medicine resources for … Continue reading

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Gamida Cell treatment granted orphan drug status

Posted: Published on January 7th, 2015

Stem cell therapy developer Gamida Cell has been awarded orphan drug status by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) for leukemia treatment NiCord. The investigational drug treats acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), Hodgkin lymphoma and myelodysplastic syndrome (MDS). Gamida Cell intends to file for NiCord orphan drug status with the EMA for other indications as well. Gamida Cell president and CEO Dr. Yael Margolin said, "Receipt of orphan drug status for NiCord in the US and Europe advances Gamida Cell's commercialization plans a major step further, as both afford significant advantages. We very much appreciate the positive feedback and support of the FDA and EMA and look forward to continuing what has been a very positive dialogue with these important agencies." The FDA and EMA grant an orphan drug designation to promote the development of products that demonstrate promise for the treatment of rare diseases or conditions. Orphan drug designation provides for various regulatory and economic benefits, including seven years of market exclusivity in the US and 10 years in the EU. NiCord is derived from a single cord blood unit, which has been expanded in culture and enriched with stem … Continue reading

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