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Georgia man turns to boxing to help ease Parkinsons disease symptoms

Posted: Published on December 13th, 2014

Published December 12, 2014 Larry Kahn high-fives his instructor after a boxing work out.(MyFoxAtlanta.com) A 55-year-old tax lawyer turned novelist thought his future was out of his hands after he was diagnosed with Parkinsons disease five years ago. It wasnt until he and his wife tried boxing that he once again found himself in control and ready to combat the disease, for which there is no cure. I feel empowered. I just feel stronger, Larry Kahn told MyFoxAtlanta.com. With his wife of 29 years Kahn has started a nonprofit called Parkinsons Disease Gladiators. The group meets three times a week for non-contact boxing classes and workouts. Hes a fighter. I love it, Ellie Kahn told the news station. On a good day, hes giving it all hes got and hes doing combat. Parkinsons disease is a progressive neurological disorder that attacks nerve cells in the brain. A patient may suffer symptoms like tremors, slowed movement, rigidity and balance problems. While there are treatment options, there currently is no cure. The National Parkinson Foundation recommends vigorous exercise to help slow down the disease and lesson symptoms, according to MyFoxAtlanta.com. I felt in much better shape. I track my physical symptoms in … Continue reading →

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Cerebral Palsy Treatment Research with Dr. Oswal’s G Therapy (NeuroG) Medicine – Video

Posted: Published on December 13th, 2014

Cerebral Palsy Treatment Research with Dr. Oswal's G Therapy (NeuroG) Medicine Interview of Dr. Oswal and Hulet Smith (OT) on Dr. Oswal's research in the treatment of cerebral palsy with G Therapy (NeuroG) Medicine - see http://www.autismtreat... By: NeurologyResearch … Continue reading →

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Progesterone treatment fails to minimize brain trauma, studies find

Posted: Published on December 13th, 2014

Published December 12, 2014 Two large studies of patients with serious brain injuries found that giving people the hormone progesterone soon after injury didnt minimize the effects of brain trauma. The results were from a study of 882 patients, called Protect III, headed by doctors at Emory University in Atlanta, and from another study of 1,195 patients, called Synapse, headed by doctors at North Shore University Hospital in Manhasset, N.Y. Both reports were published in Wednesdays issue of the New England Journal of Medicine. The findings were a disappointment, especially since a range of studies in animals had seemed to show that progesterone had a neuroprotective effect, preserving brain function despite injury. Researchers concluded that six months after injury, patients given progesterone didnt show advantages over patients given a placebo when measuring functional outcomes, such as disability and recovery. These outcomes were measured by means of an assessment known as the Glasgow Coma Scale. The progesterone was administered within four hours of injury from car and motorcycle accidents, falls and other types of accidents. This clinical trial did not show a benefit of progesterone over placebo in the improvement of outcomes in patients with acute traumatic brain injury, wrote researchers … Continue reading →

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Patient awakes from post-traumatic minimally conscious state after administration of depressant drug

Posted: Published on December 13th, 2014

A patient who had suffered a traumatic brain injury unexpectedly recovered full consciousness after the administration of midazolam, a mild depressant drug of the GABA A agonists family. This resulted in the first recorded case of an "awakening" from a minimally-conscious state (MCS) using this therapy. Although similar awakenings have been reported using other drugs, this dramatic result was unanticipated. It is reported in Restorative Neurology and Neuroscience. Traumatic brain injuries occur at high rates all over the world, estimated at 150-250 cases per 100,000 population per year. These injuries can result in several outcomes, ranging from vegetative state, minimally conscious state, severe disability to full recovery. In most cases, the outcome will cause catastrophic changes for his/her family and a signicant drain on both human and nancial resources. Two years after the injury caused by a motor vehicle accident, the patient was mildly sedated, in order to undergo a CT scan, using midazolam instead of the more commonly used propofol. As the authors described in the article, the patient began to interact with the anesthetist and soon after with his parents. He talked by cellphone with his aunt and congratulated his brother when he was informed of his graduation; … Continue reading →

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Ohio State University Researchers Will Use Kinect To Treat Multiple Sclerosis

Posted: Published on December 13th, 2014

Researchers at Ohio State University originally developed Recovery Rapids a simple, Microsoft Kinect-based kayak simulator to provide cost-effective physical therapy for stroke victims. A recent grant from the National Multiple Sclerosis Society will allow the team to explore options in the treatment of multiple sclerosis, as well. Multiple sclerosis (often abbreviated to "MS") is a degenerative disease that damages nerve cells in the brain and spinal column. MS affects more than 2.3 million people worldwide and manifests itself in numerous ways, including vision loss and complications in motor function. There is no known cure for MS. In Recovery Rapids, patients control the direction of a kayak as it travels down a river, using the Microsoft Kinect to interact with items and the environment while dodging potential hazards like floating crates and other obstacles. The notion behind the game is to force the patient to use the limb affected with motor complications without the aid of their "good" limb a form of rehabilitation known as constraint-induced (CI) movement therapy. Working on the project are Lynne Gauthier, Assistant Professor of Physical Medicine and Rehabilitation at OSU, Associate Professor Robert Crawfis of the Computer Science and Engineering department, and grad student David Maung. … Continue reading →

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Researchers discover new class of stem cells

Posted: Published on December 13th, 2014

Researchers have identified a new class of lab-engineered stem cells -- cells capable of transforming into nearly all forms of tissue -- and have dubbed them F-class cells because they cluster together in "fuzzy-looking" colonies. The discovery, which was described in a series of five papers published Wednesday in the journals Nature and Nature Communications, sheds new light on the process of cell reprogramming and may point the way to more efficient methods of creating stem cells, researchers say. Due to their extraordinary shape-shifting abilities, so-called pluripotent cells have enormous value to medical researchers. They allow scientists to study the effects of drugs and disease on human cells when experiments on actual people would be impossible, and they have given rise to the field of regenerative medicine, which seeks to restore lost or damaged organs and tissues. The F-class cells were created using genetically engineered mouse cells, and may not occur naturally outside the lab, according to senior author Andras Nagy, a stem cell researcher at Torontos Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital. However, the find suggests that there may be other classes of pluripotent cells -- or a spectrum of reprogrammed cells -- yet to be discovered, authors … Continue reading →

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2014 NCAS Philip J. Klass Award Presentation to Steven Salzberg – Video

Posted: Published on December 13th, 2014

2014 NCAS Philip J. Klass Award Presentation to Steven Salzberg On November 15, the 2014 NCAS Philip J. Klass Award for outstanding contributions in promoting critical thinking and scientific understanding was presented t... By: NCASVideo … Continue reading →

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Alnylam Pharma Announces Pipeline Growth Strategy For RNAi Therapeutics

Posted: Published on December 13th, 2014

By RTT News, December 12, 2014, 07:18:00 AM EDT (RTTNews.com) - Alnylam Pharmaceuticals, Inc. ( ALNY ) announced its pipeline growth strategy for development and commercialization of RNAi therapeutics across three Strategic Therapeutic Areas, or STArs: Genetic Medicines, Cardio-metabolic Disease, and Hepatic Infectious Disease. The company said its strategic therapeutic areas will remain focused on liver-expressed and genetically validated or pathogen-derived disease targets, with biomarkers for assessment of clinical activity early in Phase 1 trials. In Genetic Medicine STAr, Alnylam said it is advancing a broad pipeline of RNAi therapeutics for rare diseases. Across the Genetic Medicine STAr, Alnylam plans on commercializing its products through direct marketing and sales in the U.S. and EU, while leveraging its landmark partnership with Genzyme, a Sanofi company, for commercialization in the rest-of-world. In Cardio-metabolic Disease STAr, Alnylam is advancing pipeline of RNAi therapeutics toward genetically validated, liver-expressed disease targets for unmet needs in dyslipidemias, hypertension, non-alcoholic steatohepatitis, and type 2 diabetes. The company intends to seek strategic partnership opportunities for programs in Cardio-metabolic Disease STAr, while retaining significant product commercialization rights in the U.S. and EU. In Hepatic Infectious Disease STAr, Alnylam is advancing a pipeline of RNAi therapeutics that address major global … Continue reading →

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New TGen test uses the unique genetics of women to uncover neurologic disorders

Posted: Published on December 13th, 2014

PUBLIC RELEASE DATE: 12-Dec-2014 Contact: Steve Yozwiak syozwiak@tgen.org 602-343-8704 The Translational Genomics Research Institute PHOENIX, Ariz. -- Dec. 12, 2014 -- Using a basic genetic difference between men and women, the Translational Genomics Research Institute (TGen) has uncovered a way to track down the source of a neurological disorder in a young girl. TGen's discovery relies on a simple genetic fact: Men have one X and one Y chromosome, while women have two X chromosomes. This women-only factor was leveraged by TGen investigators to develop a highly accurate method of tracking down a previously unrecognized disorder of the X-chromosome. The study of a pre-teen girl, who went years with an undiagnosed neurobehavioral condition, was published today in the scientific journal PLOS ONE. TGen's findings were made within its Dorrance Center for Rare Childhood Disorders, where investigators and clinicians apply the latest tools of genomic medicine to provide answers for parents seeking to identify the disease or disorder affecting their child. The scientists sequenced, or spelled out in order, the complete genetic codes of DNA and RNA of the girl. Because girls inherit an X chromosome from each of their parents (boys inherit a Y chromosome from their father), they also … Continue reading →

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Canadian-led team of researchers shows how stem cells can be reprogrammed

Posted: Published on December 12th, 2014

TORONTO A Canadian-led international team of researchers has begun solving the mystery of just how a specialized cell taken from a persons skin is reprogrammed into an embryonic-like stem cell, from which virtually any other cell type in the body can be generated. The research is being touted as a breakthrough in regenerative medicine that will allow scientists to one day harness stem cells to treat or even cure a host of conditions, from blindness and Parkinsons disease to diabetes and spinal cord injuries. Besides creating the reprogramming roadmap, the scientists also identified a new type of stem cell, called an F-class stem cell due to its fuzzy appearance. Their work is detailed in five papers published Wednesday in the prestigious journals Nature and Nature Communications. Dr. Andras Nagy, a senior scientist at Mount Sinai Hospital in Toronto, led the team of 50 researchers from Canada, the Netherlands, South Korea and Australia, which spent four years analyzing and cataloguing the day-by-day process that occurs in stem cell reprogramming. The work builds on the 2006-2007 papers by Shinya Yamanaka, who showed that adult skin cells could be turned into embryonic-like, or pluripotent, stem cells through genetic manipulation, a discovery that garnered … Continue reading →

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