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Studies: Progesterone Fails to Help Brain Injuries

Posted: Published on December 12th, 2014

Giving people with fresh traumatic brain injuries the hormone progesterone does no good, two major studies have found. The results dash some high hopes for treating a problem that hits millions each year, from combat troops to car crash victims. Brain injuries account for more than 2 million hospitalizations or emergency room visits each year in the United States and often cause major disabilities. Roadside bombs have increased the number of troops suffering closed-head injuries, too. Some drugs can reduce symptoms, such as swelling, but none are known to improve long-term recovery and prevent disability. Work in animals and two very encouraging small trials in people suggested progesterone might. It is a female sex hormone that is thought to protect nerves and brain cells in a variety of ways, including curbing inflammation that causes swelling after an injury. The two new studies were meant to be definitive tests. In one, funded by the National Institutes of Health and led by doctors at Emory University and Grady Memorial Hospital in Atlanta, dozens of trauma centers around the U.S. aimed to enroll 1,140 patients with moderate to severe brain injuries ? mostly car crash victims. They were given infusions of progesterone or … Continue reading →

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Hormone treatment fails to heal traumatic brain injuries

Posted: Published on December 12th, 2014

Giving people with fresh traumatic brain injuries the hormone progesterone does no good, two major studies have found. The results dash some high hopes for treating a problem that hits millions each year, from combat troops to car crash victims. Brain injuries account for more than 2 million hospitalizations or emergency room visits each year in the United States and often cause major disabilities. Roadside bombs have increased the number of troops suffering closed-head injuries, too. Some drugs can reduce symptoms, such as swelling, but none are known to improve long-term recovery and prevent disability. Work in animals and two very encouraging small trials in people suggested progesterone might. It is a female sex hormone that is thought to protect nerves and brain cells in a variety of ways, including curbing inflammation that causes swelling after an injury. The two new studies were meant to be definitive tests. In one, funded by the National Institutes of Health and led by doctors at Emory University and Grady Memorial Hospital in Atlanta, dozens of trauma centres around the U.S. aimed to enrol 1,140 patients with moderate to severe brain injuries mostly car crash victims. They were given infusions of progesterone or a … Continue reading →

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Study concludes that progesterone administered to severe TBI patients, showed no benefit

Posted: Published on December 12th, 2014

PUBLIC RELEASE DATE: 10-Dec-2014 Contact: Michelle Pipia-Stiles mpstiles@msn.com 631-708-9255 North Shore-Long Island Jewish (LIJ) Health System A study concluded that after five days of treatment with a novel formulation of progesterone acutely administered to patients with severe traumatic brain injury (TBI), showed no clinical benefits. The paper entitled, "A Clinical Trial of Progesterone for Severe Traumatic Brain Injury," will be published online in The New England Journal of Medicine, December 10, 2014. This trial, referred to as SyNAPSe, reports on a large prospective randomized clinical trial that investigated the effects of progesterone administered to severe TBI patients," said Raj K. Narayan, MD, executive director, North Shore-LIJ's Cushing Neuroscience Institute and one of the co-authors of the paper. "Despite extensive experimental support in numerous animal models, as well as very promising preliminary data from smaller single center trials, this Phase III study failed to show benefit of progesterone in severe TBI." In this multinational, placebo-controlled trial, 1195 patients, 16-70 years of age, with severe TBI were randomly assigned to receive progesterone or placebo. Dosing began within eight hours after injury and continued for 120 hours. Analysis showed no treatment effect of progesterone as compared with placebo. The proportion of patients with … Continue reading →

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Ask the Doc with Rand McClain D O #1 – Video

Posted: Published on December 12th, 2014

Ask the Doc with Rand McClain D O #1 In this new Dave Mad Max video series, we sit down one-on-one with Dr. Rand McClain (who happens to be an avid weight-lifter). The focus on this particular episode is hormone replacement therapy,... By: MuscleInsider … Continue reading →

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New UQ platform aids stem cell research

Posted: Published on December 12th, 2014

Researchers at The University of Queensland are part of a global team that has identified a new type of artificial stem cell. UQ Associate Professor Christine Wells (right) said Project Grandiose had revealed it could track new ways to reprogram a normal adult cell, such as skin cells, into cells similar to those found in an early embryo. The development is expected to help researchers explore ways to arrive at new cell types in the laboratory, with important implications for regenerative medicine and stem cell science. Associate Professor Wells, who leads the Stemformatics stem cell research support unit at UQs Australian Institute for Bioengineering and Nanotechnology, said the project involved a consortium of 50 researchers from Canada, Australia, Korea, the USA and the Netherlands We all come from just one cell the fertilised egg and this cell contains within its DNA a series of instruction manuals to make all of the many different types of cells that make up our body, AIBN Associate Professor Wells said. These very early stage cells can now be made in the lab by reversing this process of development. Our research reveals the new instructions imposed on a cell when this developmental process is reversed. … Continue reading →

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UConn, Alexion stem-cell research partners

Posted: Published on December 12th, 2014

UConn and Cheshire orphan-drug maker Alexion Pharmaceuticals Inc. are partnering to expand stem-cell research into combating rare diseases. The research collaboration will focus on the discovery and testing of therapeutic candidates to treat rare and disabling disorders for which there are currently no effective treatments, both announced Thursday. "This collaboration targets unmet medical needs for patients while demonstrating the vitality of the life science community in Connecticut," said Jeff Seemann, UConn's vice president for research. It also fits with UConn's and the state's plan "to expand educational opportunities, research, and innovation in science, technology, engineering, and math (STEM) over the next decade," UConn President Susan Herbst said in a statement. Alexion's highly profitable business model relies on devising treatments, like Soliris, to treat rare a rare form of anemia and other ailments for which mainstream drugs don't currently exist. Their partnership likely will yield valuable data into diseases for which Alexion could develop new treatments. The collaboration will expand on the work of cell biologist David J. Goldhamer, who is associate Director of the UConn Stem Cell Institute. Goldhamer has identified the offending progenitor cell type that drives the pathology of a group of diseases and has developed physiologically relevant … Continue reading →

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The Future of Genetic Medicine – Maureen Turner – Video

Posted: Published on December 12th, 2014

The Future of Genetic Medicine - Maureen Turner With no background in biology or genetics, ease into an understanding of the state of genetics and issues in society with enough familiarity to discuss news ... By: Olli SFSU … Continue reading →

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R3 Stem Cell Welcomes Beverly Hills Pain Specialists Dr. George Graf as a Featured Regenerative Medicine Doctor

Posted: Published on December 12th, 2014

Beverly Hills, CA (PRWEB) December 11, 2014 R3 Stem Cell is proud to welcome Dr. George Graf as a Featured Regenerative Medicine Doctor in the Los Angeles and Beverly Hills area. Dr. Graf is a first rate pain management doctor, who offers several types of stem cell procedures and platelet rich plasma therapy for all types of spinal conditions such as neck and back pain, arthritis, disc degeneration and more. Those interested should call (844) GET-STEM for more information and scheduling. R3 Stem Cell is a nationwide provider of regenerative medicine products and education for both doctors and patients. The company only works with the top doctors and practices in the field of stem cell therapy. Dr. Graf is Double Board Certified and is very highly regarded by his peers and patients. The conditions Dr. Graf treats include degenerative disc disease, spinal arthritis, scoliosis, neuropathy, failed back surgery syndrome and more. Regenerative medicine offers the potential to not only bring pain relief, but also help repair and regenerate damaged tissue. Along with Dr. Graf being a regenerative medicine expert in the LA and Beverly Hills area, R3 also works with Dr. Raj. Dr. Raj is a Double Board Certified orthopedic … Continue reading →

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Mechanical cues reprogram normal cell lines into stem-like cells

Posted: Published on December 12th, 2014

Scientists at UB and other institutions have turned cells normally used as model cells, known as immortalized cells, into stem or, as they call it, stem-like cells, using nothing more than mechanical stress. They have done it without employing the potentially hazardous techniques previously used to obtain similar results. The researchers use the term stem-like cells to describe cells in tissue culture that have many of the biochemical markers of stem cells. Determining whether or not they can differentiate will be the focus of future research. The finding is described in a paper published recently online before print in the Proceedings of the National Academy of Sciences. The researchers discovered that changing the mechanical stresses on neuronal and other cell types in tissue culture allowed them to be reprogrammed into stem-like cells. Normal cell types in tissue culture are spread out and have differentiated internal structures, but changing cell mechanics caused the cells to turn into clusters of spherical cells that had many of the biochemical markers of cells, says Frederick Sachs, SUNY Distinguished Professor in the Department of Physiology and Biophysics and senior author. The stem cell advance was made possible by the development of a genetically encoded optical … Continue reading →

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Researchers show how stem cells can be reprogrammed

Posted: Published on December 12th, 2014

TORONTO A Canadian-led international team of researchers has begun solving the mystery of just how a specialized cell taken from a persons skin is reprogrammed into an embryonic-like stem cell, from which virtually any other cell type in the body can be generated. The research is being touted as a breakthrough in regenerative medicine that will allow scientists to one day harness stem cells to treat or even cure a host of conditions, from blindness and Parkinsons disease to diabetes and spinal cord injuries. Besides creating the reprogramming roadmap, the scientists also identified a new type of stem cell, called an F-class stem cell due to its fuzzy appearance. Their work is detailed in five papers published Wednesday in the prestigious journals Nature and Nature Communications. Dr. Andras Nagy, a senior scientist at Mount Sinai Hospital in Toronto, led the team of 50 researchers from Canada, the Netherlands, South Korea and Australia, which spent four years analyzing and cataloguing the day-by-day process that occurs in stem cell reprogramming. The work builds on the 2006-2007 papers by Shinya Yamanaka, who showed that adult skin cells could be turned into embryonic-like, or pluripotent, stem cells through genetic manipulation, a discovery that garnered … Continue reading →

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