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Stem Cell Therapy | stem cells osteoarthritis independent – Video

Posted: Published on December 5th, 2014

Stem Cell Therapy | stem cells osteoarthritis independent http://www.arthritistreatmentcenter.com On the flip side, another study refutes the study I commented on the other day regarding stem cells from osteoarthritis patients Chondrogenic Potential... By: Nathan Wei … Continue reading

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Predicting the storm: Can computer models improve stem cell transplantation?

Posted: Published on December 5th, 2014

PUBLIC RELEASE DATE: 4-Dec-2014 Contact: John Wallace wallacej@vcu.edu 804-628-1550 Virginia Commonwealth University @vcunews Is the human immune system similar to the weather, a seemingly random yet dynamical system that can be modeled based on past conditions to predict future states? Scientists at VCU Massey Cancer Center's award-winning Bone Marrow Transplant (BMT) Program believe it is, and they recently published several studies that support the possibility of using next-generation DNA sequencing and mathematical modeling to not only understand the variability observed in clinical outcomes of stem cell transplantation, but also to provide a theoretical framework to make transplantation a possibility for more patients who do not have a related donor. Despite efforts to match patients with genetically similar donors, it is still nearly impossible to predict whether a stem cell transplant recipient will develop potentially fatal graft-versus-host disease (GVHD), a condition where the donor's immune system attacks the recipient's body. Two studies recently published by the online journal Frontiers in Immunology explored data obtained from the whole exome sequencing of nine donor-recipient pairs (DRPs) and found that it could be possible to predict which patients are at greatest risk for developing GVHD and, therefore, in the future tailor immune suppression therapies … Continue reading

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1) My Journey with Ulcerative Colitis and Pouchitis. (Short Version) – Video

Posted: Published on December 5th, 2014

1) My Journey with Ulcerative Colitis and Pouchitis. (Short Version) A short video describing my journey. The animation came By: Small Bowel and Large Bowel Surgery https://www.youtube.com/watch?v=1H5vuQzp4As Total Colectomy... By: Living with Pouchitis and Digestive Disorders … Continue reading

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My story Crohns & Ulcerative Colitis week 2014 – Video

Posted: Published on December 5th, 2014

My story Crohns Ulcerative Colitis week 2014 The week of December 1-7 is Crohns and Ulcerative Colitis awareness week. This is my story, being a young women with no colon. "No colon Still Rollin, Young,... By: Katie Christie … Continue reading

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Chris Henry on comeback after stroke

Posted: Published on December 5th, 2014

Ireland flanker Chris Henry admits he was terrified after suffering a stroke last month. A blocked blood vessel in the 30-year-old's brain caused him to have a Transient Ischaemic Attack, or mini stroke, hours before Ireland beat South Africa 29-15 on November 8. Ulster's Henry was pulled out of the Test against the Springboks and at first it was thought he had suffered a severe migraine. But after four days of treatment at the St Vincent's Hospital in Dublin, the true cause was confirmed. It was found he had a hole in his heart, which led to the mini stroke and left Henry fearing the worst. "It's been a scary few weeks to be honest but I feel very lucky that I was in that environment and getting such incredible medical expertise so quickly," he told Ulster's official website. "They got to the bottom of things swiftly and I think that's the most important thing; when something like that happens, the unknown is the scary thing and to have clarity on what was going on and having the problem fixed so quickly -- for me, I feel very lucky." Henry is now on the comeback trail after having surgery last … Continue reading

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Novartis Posts Phase 3 Data For Gilenya In MS

Posted: Published on December 5th, 2014

By Estel Grace Masangkay Novartis reported the latest findings from the Phase 3 trial of its drug Gilenya (fingolimod) in primary progressive multiple sclerosis (PPMS), a difficult form of multiple sclerosis. Gilenya is approved by the U.S. Food and Drug Administration (FDA) as first-line treatment for relapsing forms of MS in adult patients. The drug is approved in the EU for the treatment of highly active relapsing-remitting MS (RRMS). Gilenya is designed to target the focal and diffuse central nervous system (CNS) damage that is behind the loss of function in the disease. Its mechanism of action prevents cells which drive focal inflammation (known as peripheral action) while reducing diffuse damage by hindering the activation of harmful cells in the CNS. Addressing both focal and diffuse damage in relapsing MS is critical to preserving a patients physical and cognitive function. Earlier this year, Novartis announced positive results for the drug showing its efficacy across key measures of MS disease activity. However, the company reported disappointing results for the Phase 3 INFORMS study of Gilenya in PPMS. Data showed no significant difference between fingolimod and placebo on a combination of MS disability measures. The drugs safety profile was reported to be … Continue reading

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Stem cell research PS – Video

Posted: Published on December 5th, 2014

Stem cell research PS By: Afrakomah Danko … Continue reading

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Genetic Errors Linked to More ALS Cases Than Scientists Had Thought

Posted: Published on December 5th, 2014

Contact Information Available for logged-in reporters only Newswise Genetic mutations may cause more cases of amyotrophic lateral sclerosis (ALS) than scientists previously had realized, according to researchers at Washington University School of Medicine in St. Louis and Cedars-Sinai Medical Center in Los Angeles. The scientists also showed that the number of mutated genes influences the age when the fatal paralyzing disorder first appears. ALS, also known as Lou Gehrigs disease, destroys the nerve cells that control muscles, leading to loss of mobility, difficulty breathing and swallowing, and eventually paralysis and death. Understanding the many ways genes contribute to ALS helps scientists seek new treatments. The study appears online in Annals of Neurology. Scientists have linked mutations in more than 30 genes to ALS. Alone or in combination, mutations in any of these genes can cause the disease in family members who inherit them. Roughly 90 percent of patients with ALS have no family history of the disease, and their condition is referred to as sporadic ALS. Scientists had thought mutations contributed to barely more than one in every 10 cases of sporadic ALS. But researchers recently started to suspect that patients with sporadic ALS carry mutations in the 30 genes … Continue reading

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Study shows more patients with ALS have genetic origin than previously thought

Posted: Published on December 5th, 2014

PUBLIC RELEASE DATE: 5-Dec-2014 Contact: Sandy Van sandy@prpacific.com 808-526-1708 Cedars-Sinai Medical Center @cedarssinai LOS ANGELES (Dec. 4, 2014) - Genetics may play a larger role in causing Lou Gehrig's disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS. The study, conducted by investigators at Cedars-Sinai and Washington University in St. Louis, also showed that patients with defects in two or more ALS-associated genes experience disease onset about 10 years earlier than patients with single-gene mutations. "These findings shed new light on the genetic origins of ALS, especially in patients who had no prior family history of the disease," said Robert H. Baloh, MD, PhD, director of neuromuscular medicine in the Department of Neurology and director of the ALS Program at Cedars-Sinai. Baloh is senior author of the study, published online in Annals of Neurology. Typically, researchers classify 90 percent of ALS cases as "sporadic," meaning they occur in patients without a family history of the disease. In their study, however, the researchers found a significant degree of genetic involvement in … Continue reading

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Study Shows More Patients With Lou Gehrig's Disease Have Genetic Origin Than Previously Thought

Posted: Published on December 5th, 2014

Contact Information Available for logged-in reporters only Newswise LOS ANGELES (Dec. 4, 2014) Genetics may play a larger role in causing Lou Gehrigs disease than previously believed, potentially accounting for more than one-third of all cases, according to one of the most comprehensive genetic studies to date of patients who suffer from the condition also known as amyotrophic lateral sclerosis, or ALS. The study, conducted by investigators at Cedars-Sinai and Washington University in St. Louis, also showed that patients with defects in two or more ALS-associated genes experience disease onset about 10 years earlier than patients with single-gene mutations. These findings shed new light on the genetic origins of ALS, especially in patients who had no prior family history of the disease, said Robert H. Baloh, MD, PhD, director of neuromuscular medicine in the Department of Neurology and director of the ALS Program at Cedars-Sinai. Baloh is senior author of the study, published online in Annals of Neurology. Typically, researchers classify 90 percent of ALS cases as sporadic, meaning they occur in patients without a family history of the disease. In their study, however, the researchers found a significant degree of genetic involvement in patients with no family history. Examining … Continue reading

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