Contact Information Available for logged-in reporters only Embargoed for release until December 7, 2014 10:45 AM PT / 1:45 PM ET Newswise SEATTLE, December 7, 2014 Despite recent advances in anti-epileptic drug (AED) development, many adults with epilepsy continue to struggle with seizure control. New findings from a phase 3 clinical trial (Poster 2.417) to be unveiled at the 68th Annual Meeting of the American Epilepsy Society, suggest an additional therapeutic option may be coming down the pike. Researchers from the Mid-Atlantic Epilepsy and Sleep Center and other participating medical centers performed a randomized, double-blind, placebo-controlled study in the United States and Europe on the efficacy and safety of the drug brivaracetam, an analog of the commonly used AED levetiracetam, in adults with poorly controlled partial onset seizures. This first presentation of primary study results from the latest Phase 3 brivaracetam study is highly anticipated in the epilepsy community. The two primary outcomes in this study evaluating adjunctive brivaracetam in the treatment of partial-onset seizures in adults with epilepsy were statistically significant and clinically relevant, said Dr. Pavel Klein, director, Mid-Atlantic Epilepsy and Sleep Center. The authors evaluated fixed doses of 100mg/day or 200 mg/day brivaracetam as an adjunctive treatment … Continue reading
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