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Anti-Epilepsy Drug Could Help Drinkers Curb Habit

Posted: February 22, 2014 at 2:49 am

By Marcus Johnson

A drug that is currently being used to treat epilepsy has shown promise in helping drinkers consume less alcohol. A study conducted by the University of Pennsylvanias Center for Studies of Addiction treated patients with Topamax (topiramate). The study included 138 heavy drinkers and concluded that those drinkers were up to five times less likely than a placebo group to have a heavy drinking day after receiving treatment. They were also more likely than the placebo group to have a day of no drinking at all.

Dr. Henry Kranzler believes the study shows the potential of Topamaxs use as a drug to help those struggling with alcohol. This study represents an important next step in understanding and treating problem drinking. Our study is the first we are aware of in which topiramate was evaluated as an option for patients who want to limit their drinking to safe levels, rather than stop drinking altogether. Our hope is that the study will result in additional research focusing to help patients who have struggled with heavy drinking and the problems it causes, but who are unable or unwilling to abstain from alcohol altogether.

The study also found that there could be a genetic component to treatment. Forty-percent of European-Americans in the study benefited from Topamax treatment, suggesting that treatment in the future could be individualized for certain individuals. Kranzelr believes that the study could eventually lead to a model which could help predict if a drinker actually needs treatment to curb his or her habit.

Source: http://news.health.com/2014/02/19/drug-might-help-heavy-drinkers-limit-their-booze/

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Marijuana Chemical Could Treat Children with Epilepsy

Posted: at 2:48 am

A new strain of marijuana has motivated hundreds of families with epileptic children to pack up and move to Colorado to legally obtain the drug. The jury is still out on whether this special pot strain does indeed have measurable benefits, or if its even safe, but drug companies are racing to replicate its effects in pill form.

The therapeutic pot strain, called Charlottes Web, is bred not have THCthe active ingredient in marijuana. Its namesake is 5-year-old Charlotte Figi, a Colorado girl who has Dravets syndrome. Charlotte reportedly went from having 300 seizures a week in 2010 to being virtually seizure-free two years laterafter connecting with a nonprofit that grows and produces an oilinfused with the special marijuana strain.

Charlottes story has renewed curiosity among researchers in a particular chemical in pot, cannabidiol (CBD), which could have anti-epileptic properties in humans.

CBD has shown some signs of promise of suppressing seizures in animals, but testing in humans is still in its infancy. A small number of case reports exist with conflicting results, and researchers have conducted just four placebo-controlled clinical trials that focused on CBDs efficacy as a treatment for epilepsy.

Three of the four trials reported at least some reduction of seizure occurrences, according to a 2014 review published in Drug Testing and Analysis. However, the trials only involved 48 patients in total, too small a group from which to draw reliable statistics.

The first clinical trial conducted in humans, published in 1980 in the journal Pharmacology, is most frequently cited as evidence of CBDs promise. Four out of eight test subjects that suffered from epilepsy remained nearly seizure-free throughout the 4-1/2-month experiment, while three others reported slight improvements. Additionally, people who took CBD didnt report psychoactive side effects associated with smoking marijuana.The patients took the CBD in 200- to 300-milligram capsules once a day.

Despite the lack of definitive evidence, the National Epilepsy Foundation came out Thursday to voice strong support for continued research of medical marijuana, encouraging lawmakers to continue to allow families to use marijuana as a treatment for their children.

This year will shift CBD research up a gear. In October 2013 the U.S. Food and Drug Administration ruled that clinical trials of CBDs efficacy in epileptic children could move forward. Clinical trials of a drug called Epidiolex, which contains a purified form of CBD, started this month. The study will be conducted at five sites, each with 25 children who have epilepsy.

Marcia Roberta Cillio, director of research at UC San Francisco, oversees one of the trial locations. She explained the research in a news release from UCSF:

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MS Patients Want More Treatment Options

Posted: at 2:47 am

Updated: Friday, February 21 2014, 10:49 PM CST

The FDA has hit a new nerve with the medical community.

A drug to treat multiple sclerosis is not approved in the United States, even though it was approved in three other countries.

The controversy is whether the trials on the drug Lemtrada were done correctly.

Lemtrada was tested against another drug that was already on the market to see if it worked better. Normally, studies are done with the actual drug and placebo, but in this case, the patients and doctors knew which drugs they took.

The FDA said based on the unusual design of the trials, it does not have clear answers on if Lemtrada worked or not. However, patients and doctors involved with the study insisted it was effective.

It took 29 years before Russell McCoy’s life centered on needles and medicine. To control his multiple sclerosis, Russell gives himself shots three days a week. His life now is a 180-degree difference from his life before he was diagnosed six years ago.

“The left side of my body started to deplete,” McCoy said. “I couldn’t keep up with doing things.”

Russell faces daily debilitating symptoms. His muscles weakened and he has bad bouts of vertigo. He even struggles with small things like playing guitar.

“Something you’ve been playing your whole life it’s kind of hard to see it wash away,” McCoy said.

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Female Hormone Replacement Testimonial – February 2014 – Video

Posted: at 2:46 am



Female Hormone Replacement Testimonial – February 2014
After becoming shy and withdrawn, and having sleep issues, hot flashes and mood changes, Robin came to Allure Medical Spa for hormone replacement therapy. Sh…

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Dr. Theresa Ramsey | Longevity Drink – Video

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Dr. Theresa Ramsey | Longevity Drink
http://www.DrRamsey.com Try this powerful recipe using turmeric, ginger and other ingredients. Research shows turmeric may reduce Alzheimer's, Arthritis and …

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Image Inquiry Question Stimulation for Stem Cell Research – Video

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Image Inquiry Question Stimulation for Stem Cell Research
It is challenging to come up with Good Inquiry Questions “in a vacuum” so this mini video of images was prepared to help stimulate such questions for Science…

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Meet a CSIR geneticist who specialises in stem cell research – Video

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Meet a CSIR geneticist who specialises in stem cell research
Dr Janine Scholefield became inspired to study genetics during a high-school biology lesson when she was taught how the laws of inheritance were derived from…

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Self Regional Healthcare, Clemson, Genetic Center create national genetics research hub

Posted: at 2:45 am

PUBLIC RELEASE DATE:

21-Feb-2014

Contact: Peter Hull [email protected] 843-209-8341 Clemson University

GREENWOOD, S.C. A new partnership will establish formal collaboration among genetic researchers and Clemson University faculty at the Greenwood Genetic Center and Self Regional Healthcare, expanding an already successful working relationship.

Self Regional Healthcare will support the Clemson University Center for Human Genetics with a gift of $5.6 million over three years. The gift consists of an initial contribution of $2 million for the center’s facilities and a subsequent contribution of $3.6 million to support research in genetics and human diagnostics at the facility located on the Greenwood Genetic Center campus.

“Today’s announcement will create a new pipeline for genetic research,” said John Pillman, chairman of the Self Regional board of trustees. “The collaboration of these three partners will ultimately connect genetic therapeutics research to patients.”

Jim Pfeiffer, president and chief executive officer of Self Regional, said the partnership will accelerate the rate of innovation in genetic medicine. “This is what I like to call a win-win-win scenario,” said Pfeiffer.

Steve Skinner, director of the Greenwood Genetic Center, said such collaborations are crucial to turning research advances into clinically available therapies for patients, not only in Greenwood and across South Carolina, but globally.

“This collaboration is a major step forward for patients as we combine the resources and strengths of each institution: Self’s commitment to patient care, Clemson’s expertise in basic scientific research and our experience with genetic disorders and treatment,” Skinner said.

Self Regional and the Genetic Center have had an affiliation agreement since 1975 with the Genetic Center’s clinical faculty serving as the Department of Medical Genetics for Self Regional.

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Hair Loss Treatment, Best Hair Fall Treatment Mumbai India – Video

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Hair Loss Treatment, Best Hair Fall Treatment Mumbai India
Hair Fall Hair Loss is becoming more more common, in both men (male pattern baldness alopecia) women (female pattern baldness alopecia). What are the c…

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'Largest ever' trial of adult stem cells in heart attack patients begins

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The largest ever trial of adult stem cell therapy in heart attack patients has begun at The London Chest Hospital in the UK.

Heart disease is the world’s leading cause of death. Globally, more than 17 million people died from heart disease last year. In the US, over 1 million people suffer a heart attack each year, and about half of them die.

Heart attacks are usually caused by a clot in the coronary artery, which stops the supply of blood and oxygen to the heart. If the blockage is not treated within a few hours, then it causes the heart muscle to die.

The stem cell trial – titled “The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on allcause mortality in acute myocardial infarction,” or “BAMI” for short – has been made possible due to a 5.9 million ($8.1 million) award from the European Commission.

The full study involves 19 partners across France, Germany, Italy, Finland, Denmark, Spain, Belgium, Poland, the Czech Republic and the UK.

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