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NeoStem’s Stem Cell Therapy Fails Mid-Stage Heart Attack Study

Posted: Published on November 19th, 2014

By: Adam Feuerstein | 11/18/14 - 10:16 AM EST Inject a cocktail of undifferentiated stem cellsinto a patient who has suffered a heart attack, and days or even weekslater, the stem cells transform into cardiac cells and rebuild the damaged heart muscle. Months later, the patient has a "new" healthy heart.It's a great story. But so far, the proof remains elusive though not for a lack of trying. The latest company to fulfill this ambitious scenario is NeoStem (NBS) which presented disappointing (but not surprising) results from a small study of its proprietary cardiac stem-cell therapy NBS10 at the American Heart Association annual meeting Monday. NeoStem tried to put some positive spin on the bad news but shares are down 25% to $5.10. NBS10, formerly known as AMR-001, is an autologous stem-cell therapy derived from a patient's own bone marrow. When injected back into patients following a heart attack, the stem cells are supposed torestore blood flow, rebuild damaged cardiac muscle and improve function. Except in NeoStem's study, NBS10 fell short on two primary endpoints designed to assess the therapy's efficacy. The study used non-invasive imaging to assess blood flow through the heart, six months after a single infusion of … Continue reading →

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Heart muscle inflammation, swelling peak twice after heart attack

Posted: Published on November 19th, 2014

Results of a new study challenge the current consensus in cardiology that peak myocardial edema, or heart muscle swelling, only occurs just after a myocardial infarction, or heart attack. In the study, presented as a Late-Breaking Clinical Trial at the American Heart Association (AHA) Scientific Sessions 2014 and published simultaneously in the Journal of the American College of Cardiology (JACC), scientists discovered a second wave of swelling and inflammation occurs within a week of a heart attack. The researchers from the Mount Sinai Heart at Icahn School of Medicine at Mount Sinai and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) in Spain believe their identification of this second wave of inflammation may advance the use of cardiac magnetic resonance (CMR) imaging to better assess initial damage caused by a heart attack. Furthermore, it may enable the design of future targeted therapies that interrupt the two inflammatory reactions to better protect a patient's heart muscle. Previously, it was widely accepted that heart muscle responds in a stable and progressive way to a heart attack or blockage, with the response pattern starting right after the attack and lasting at least a week. "Our study found that the inflammatory reaction of the … Continue reading →

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Skypilot – Biology of the Brain – Video

Posted: Published on November 19th, 2014

Skypilot - Biology of the Brain An original song from our show on October 25th at Nietzsches in Buffalo, New York. By: SkypiLoT … Continue reading →

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Kernel methods and computational biology — Jean-Philippe Vert (Part 3) – Video

Posted: Published on November 19th, 2014

Kernel methods and computational biology -- Jean-Philippe Vert (Part 3) By: MLSS Iceland 2014 … Continue reading →

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American Education Week – Biology FOLDABLES Fun! – Video

Posted: Published on November 19th, 2014

American Education Week - Biology FOLDABLES Fun! We're celebrating American Education Week with a fun video featuring a FOLDABLES activity for biology. By: McGraw-Hill Education … Continue reading →

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Biology: November 17, 2014 – Video

Posted: Published on November 19th, 2014

Biology: November 17, 2014 By: man1eating1squirrel … Continue reading →

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Ebola surveillance may become quicker and cheaper

Posted: Published on November 19th, 2014

PUBLIC RELEASE DATE: 18-Nov-2014 Contact: Joel Winston joel.winston@biomedcentral.com 44-203-192-2081 BioMed Central @biomedcentral A new method for examining the Ebola virus genome could make surveillance quicker and cheaper for West African nations, and help detect new forms of the virus. The detailed procedure is being shared with the research community along with the study paper, which is freely available in the open access journal Genome Biology. With over 13,000 cases and nearly 5,000 deaths in eight affected countries, the current Ebola outbreak in West Africa is the largest to date, the first to spread to densely populated urban areas, and represents the first time the virus has been diagnosed outside of Africa. To help contain the current outbreak, experts say that surveillance remains key. Detecting viral RNA genomes in suspected fever patients helps confirm diagnoses of Ebola, and aids decisions to quarantine patients and begin tracing their contacts. Yet sequencing viral genomes directly from blood samples holds many challenges. Samples contain very little viral RNA and are heavily contaminated with human RNA, while hot climates cause rapid degradation of viral RNA material and biosafety measures bring further complications for handling samples. As such few Ebola genomes have been sequenced. Research led … Continue reading →

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Humerus Bone – Anatomy, Definition & Function – Human Anatomy |Kenhub – Video

Posted: Published on November 19th, 2014

Humerus Bone - Anatomy, Definition Function - Human Anatomy |Kenhub Find more videos at: https://www.kenhub.com Subscribe to our YouTube channel: http://bit.ly/VOEG2I On this tutorial, I will do a brief introduction to the Humerus. The humerus is a long bone... By: Kenhub … Continue reading →

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THE 1 YEAR ANNIVERSARY OF ANATOMY OF A WORSHIPPER TOUR WITH JOAN PAUL. – Video

Posted: Published on November 19th, 2014

THE 1 YEAR ANNIVERSARY OF ANATOMY OF A WORSHIPPER TOUR WITH JOAN PAUL. Back home, Live in Benin City, Arkmuzik Int'l presents "ANATOMY OF WORSHIPPER" with JOAN PAUL on Mon. 15th Dec.2014 @ 3pm. It a time of thanksgiving to our father, who has caused hersel and ... By: joan-paul momodu … Continue reading →

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anatomy 22 part 3 – Video

Posted: Published on November 19th, 2014

anatomy 22 part 3 Pericardial effusion (cont.) Cardiac tamponade Cardiocentesis Heart shape Sternocostal surface Base (post. Surface) Diaphragmatic surface Champers of the heart Right atrium Right ventricle. By: med uqu … Continue reading →

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