Stem cells are immature cells that eventually develop into the various types of mature blood cells: A stem cell transplant replaces defective or damaged cells in patients whose normal blood cells have been crowded out by cancerous cells. Transplants can also be used to treat hereditary disorders such as sickle cell anemia, or to help patients recover from or better tolerate cancer treatment. Stem cells for transplant come from the following sources: Autologous transplant: cells are taken from the patient's own bone marrow before chemotherapy and are then replaced after cancer treatment. Allogeneic transplant: stem cells come from a donor whose tissue most closely matches the patient. Umbilical cord blood from newborn infants is extracted from the placenta after birth and saved in special cord blood banks for future use. MDAnderson's Cord Blood Bank actively seeks donations of umbilical cords. Human leukocyte antigen, or HLA, typing is the method by which stem cell transplant patients are matched with eligible donors. HLA are proteins that exist on the surface of most cells in the body. HLA markers help the body distinguish normal cells from foreign cells, such as cancer cells. The closest possible match between the HLA markers of the donor … Continue reading
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