Contact Information Available for logged-in reporters only Newswise One remarkable quality of pluripotent stem cells is they are immortal in the lab, able to divide and grow indefinitely under the right conditions. It turns out this ability also may exist further down the development path, with the workhorse progenitor cells responsible for creating specific tissues. A team from the Morgridge Institute for Research regenerative biology group, led by University of Wisconsin-Madison professor and stem cell pioneer James Thomson, discovered a way to impose an immortal-like state on mouse progenitor cells responsible for producing blood and vascular tissue. By regulating a small number of genes, the cells became trapped in a self-renewing state and capable of producing functional endothelial, blood and smooth muscle cells. The finding, to be published in the December 9, 2014 issue of Stem Cell Reports, points to a potential new approach to developing cells in the lab environment for use in drug screening, therapies and as a basic research tool. The biggest takeaway for me is the ability to arrest development of these cells, says David Vereide, a Morgridge fellow in regenerative biology and lead author on the paper. Normally, these cells are ephemeral and get used … Continue reading
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