Femto Medicine - Part 3278

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First-in-Class Epilepsy Treatment Fycompa (Perampanel) Launches in Australia

Posted: Published on November 3rd, 2014

Hatfield, England (ots/PRNewswire) - PRESS RELEASE FOR EU MEDIA ONLY: NOT FOR SWISS/U.S. JOURNALISTS Fycompa(R) (perampanel), the first in an entirely new class of treatment for partial onset seizures (the most common form of epilepsy), has received reimbursement in Australia. It is indicated for the adjunctive treatment of partial onset seizures, with or without secondarily generalised seizures, in patients with epilepsy aged 12 years and older.[1] Perampanel is the only licensed anti-epileptic drug (AED) to selectively target AMPA receptors, a protein in the brain which plays a critical role in the spread of seizures.[2] This mechanism of action is different to other currently available AEDs. In addition, perampanel has the added benefit of convenient, once-daily dosing at bedtime[1] and, significantly, is the only new-generation partial epilepsy treatment approved to treat adolescents (>12 years) with epilepsy from launch. Epilepsy is one of the most common neurological conditions in the world.[3] In Australia it is estimated that 225,000 Australians live with epilepsy, and approximately 800,000 will be diagnosed with the condition at some stage in their life.[4] The successful treatment of partial onset seizures remains a significant challenge in some people and the incidence of uncontrolled partial epilepsy remains high despite many … Continue reading →

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Hormone and Estrogen Replacement Therapy Problems

Posted: Published on November 3rd, 2014

HRT and feedback problem As the estrogens go up, the hotflashes should go away. Have you had a blood (serum) estradiol level drawn? The reason I ask is that sometimes estrogen replacement can get too high while chasing hotflashes and the high levels actually cause stress-related hot flashes. I've seen this in some women and they actually need to decrease levels of HRT. Also keep in mind there are other causes of hotflashes. They are listed at hot flashes causes. They include: hyperthyroidism/thyrotoxicosis anxiety, panic attacks, carcinoid syndrome, pheochromocytoma, drugs, diencephalic epilepsy, tuberculosis, and malaria. If your serum estrogen level (usually estradiol) is normal, your doctor may need to look for some of these other causes. Normal estradiol levels depend on the laboratory and units it's reported in. In menopause, the range may be 10-20 pg/ml or 40-70 pmol/L. In normal reproductive age women during the menstrual cycle, estradiol levels range from 50-400 pg/ml. In our lab, values under 100 pg/ml can be associated with hot flashes so if your levels are the same units, you might need more estrogen as your doctor has indicated. What different preparations have you tried other than the patch and the Estratest? These are … Continue reading →

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