PUBLIC RELEASE DATE: 30-Oct-2014 Contact: Leila Gray leilag@uw.edu 206-685-0381 University of Washington Health Sciences/UW Medicine A newly developed mouse model suggests that genetic factors are behind the mild-to-deadly range of reactions to the Ebola virus. People exposed to Ebola vary in how the virus affects them. Some completely resist the disease, others suffer moderate to severe illness and recover, while those who are most susceptible succumb to bleeding, organ failure and shock. In earlier studies of populations of people who have contracted Ebola, these differences are not related to any specific changes in the Ebola virus itself that made it more or less dangerous; instead, the body's attempts to fight infection seems to determine disease severity. In the Oct. 30 edition of Science, scientists describe strains of laboratory mice bred to test the role of an individual's genetic makeup in the course of Ebola disease. Systems biologists and virologists Angela Rasmussen and Michael Katze from the Katze Laboratory at the University of Washington Department of Microbiology led the study in collaboration with the National Institutes of Health's Rocky Mountain Laboratories in Montana and University of North Carolina at Chapel Hill. Research on Ebola prevention and treatment has been hindered by … Continue reading
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