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Cell transplant helps paralyzed man walk with frame

Posted: Published on October 21st, 2014

They used a nerve bridge constructed between the two stumps of the damage spinal column. A Bulgarian man who was paralyzed from the chest down in a knife attack can now walk with the aid of a frame after receiving pioneering transplant treatment using cells from his nose. The technique, described as a breakthrough by a study in the journal Cell Transplantation, involved transplanting what are known as olfactory ensheathing cells into the patients spinal cord and constructing a nerve bridge between two stumps of the damaged spinal column. We believe this procedure is the breakthrough which, as it is further developed, will result in a historic change in the currently hopeless outlook for people disabled by spinal cord injury, said Geoffrey Raisman, a professor at University College Londons (UCL) institute of neurology, who led the research. The 38-year-old patient, Darek Fidyka, was paralyzed after suffering stab wounds to his back in 2010. Following 19 months of treatment, he has recovered some voluntary movement and some sensation in his legs, his medics said. The Nicholls Spinal Injury Foundation, a British-based charity which part-funded the research, said in statement that Fidyka was continuing to improve more than predicted, and was now … Continue reading →

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Nose cell transplant helps paralyzed man walk again

Posted: Published on October 21st, 2014

LONDON, THE UK - A Bulgarian man who was paralysed from the chest down in a knife attack can now walk with the aid of a frame after receiving pioneering transplant treatment using cells from his nose. The technique, described as a breakthrough by a study in the journal Cell Transplantation, involved transplanting what are known as olfactory ensheathing cells into the patient's spinal cord and constructing a "nerve bridge" between two stumps of the damaged spinal column. "We believe... this procedure is the breakthrough which, as it is further developed, will result in a historic change in the currently hopeless outlook for people disabled by spinal cord injury," said Geoffrey Raisman, a professor at University College London's (UCL) institute of neurology, who led the research. The 38-year-old patient, Darek Fidyka, was paralysed after suffering stab wounds to his back in 2010. Following 19 months of treatment, he has recovered some voluntary movement and some sensation in his legs, his medics said. The Nicholls Spinal Injury Foundation, a British-based charity which part-funded the research, said in statement that Fidyka was continuing to improve more than predicted, and was now able to drive and live more independently. Read more: Nose cell … Continue reading →

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World first as man whose spinal cord was severed walks: Paralysed fireman recovers thanks to UK research

Posted: Published on October 21st, 2014

Darek Fidyka is the first person in the world to recover from chronic injuries Fireman was paralysed from the waist down after severing spinal chord The Bulgarian received treatment pioneered by University College London Cells taken from his nose injected to spine and regrew to repair broken link By Ben Spencer, Science Reporter for the Daily Mail Published: 19:07 EST, 20 October 2014 | Updated: 19:58 EST, 20 October 2014 A fireman paralysed from the waist down after his spinal cord was completely severed has regained the ability to walk thanks to British scientists. Darek Fidyka, 40, is believed to be the first person in the world to recover from such chronic injuries, in an achievement hailed as more impressive than putting a man on the Moon. Mr Fidykas spinal cord was sliced in half during a stabbing four years ago, leaving him paralysed below the waist. Darek Fidyka has been able to walk again after receiving pioneering treatment which has repaired his severed spine Amazingly, he has now been able to resume an independent life walking with a frame and even driving a car thanks to a revolutionary technique pioneered at University College London. Mr Fidyka, from Bulgaria, suffered … Continue reading →

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Head injury causes immune system to attack brain, new study finds

Posted: Published on October 21st, 2014

Scientists have uncovered a surprising way to reduce the brain damage caused by head injuries -- stopping the body's immune system from killing brain cells. The study, published in the open access journal Acta Neuropathologica Communications, showed that in experiments on mice, an immune-based treatment reduced the size of brain lesions. The authors suggest that if the findings apply to humans, this could help prevent brain damage from accidents, and protect players of contact sports like American football, rugby and boxing. To date, there are no effective treatments to prevent or reverse the damage sustained after brain injury. The researchers were testing the theory that blows to the head cause brain damage, in part, because of the breakdown of the blood-brain barrier, allowing the immune cells in the blood to come into contact with brain cells and destroy them. They hypothesized that mice missing a vital immune component would have less brain damage from trauma, and that a treatment which blocks a component of the immune system would prevent damage. The component they were working on was CD74, which plays a crucial part in the immune system's response to disease-causing agents. CD74 is broken into products that fit into the … Continue reading →

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Research reveals likelihood, onset of MS diagnosis among patients with inflammatory eye disease

Posted: Published on October 21st, 2014

PUBLIC RELEASE DATE: 19-Oct-2014 Contact: Media Relations media@aao.org American Academy of Ophthalmology @aao_ophth CHICAGO Oct. 19, 2014 The results of the largest retrospective study of multiple sclerosis (MS) in uveitis patients has revealed that nearly 60 percent of patients with both diseases were diagnosed with each within a five-year span. The study is being presented today at AAO 2014, the 118th annual meeting of the American Academy of Ophthalmology. While it has long been known that there is an association between the eye condition and MS, this is the first study to provide a detailed description of the relative onset of uveitis and MS and to calculate the likelihood of an MS diagnosis among uveitis patients. Diagnosed in approximately 38,000 Americans a year, uveitis causes swelling and irritation of the middle layer of the eye and can lead to permanent vision loss if left untreated. It is well established in the medical community that uveitis can be a sign of MS and it is estimated that 1 to 10 percent of MS patients have uveitis. The disease affects approximately 2.3 million people worldwide, causes irreversible nerve deterioration and is notoriously difficult to diagnose. To achieve a better understanding of the … Continue reading →

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Stem Cell Research | Trichology | Hair Restoration Dallas – Video

Posted: Published on October 21st, 2014

Stem Cell Research | Trichology | Hair Restoration Dallas As Dallas's premiere Hair Restoration Center, we are very excited about the new possibilities of using Stem Cells, to treat Hair Loss and Baldness. By: KeyElementMedia … Continue reading →

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Stem cell Research for Paralysis – Video

Posted: Published on October 21st, 2014

Stem cell Research for Paralysis Website - http://www.drdassans.com Contact Us - +91-7355793557, +0181-5040006. Email: drdassans@gmail.com enquiry@drdassans.com. By: Dr Dassan's Ayurvedic Herbal Formulations … Continue reading →

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Parent stem cells controlled by progeny

Posted: Published on October 21st, 2014

New York, Oct 20 (IANS): Megakaryocytes or large cells found in bone marrow play a critical role in regulating stem cells, found a study. In fact, haematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The study is the first to show that haematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes). The results could lead to new treatments for patients recovering from chemotherapy or organ transplantation. "Our results suggest that megakaryocytes might be used clinically to facilitate adult stem cell regeneration and to expand cultured cells for adult stem cell transplants," said lead author of the study Meng Zhao from the Stowers Institute for Medical Research in Missouri, US. The researchers found that megakaryocytes directly regulate the function of murine (mice) haematopoietic stem cells - adult stem cells that form blood and immune cells and that constantly renew the body's blood supply. These cells can also develop into different types of blood cells, including white blood cells, red blood cells and platelets. The researchers discovered that as a terminally differentiated progeny, megakaryocytes regulate haematopoietic stem cells by performing two previously unknown functions. "Megakaryocytes can directly regulate the amount of haematopoietic stem cells … Continue reading →

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'Mega' cells control growth of blood-producing cells

Posted: Published on October 21st, 2014

While megakaryocytes are best known for producing platelets that heal wounds, these "mega" cells found in bone marrow also play a critical role in regulating stem cells according to new research from the Stowers Institute for Medical Research. In fact, hematopoietic stem cells differentiate to generate megakaryocytes in bone marrow. The Stowers study is the first to show that hematopoietic stem cells (the parent cells) can be directly controlled by their own progeny (megakaryocytes). The findings from the lab of Stowers Investigator Linheng Li, Ph.D., described in the Oct. 19 issue of the journal Nature Medicine, could cause researchers to rethink what they know about the workings of megakaryocytes and potentially lead to new treatments for patients recovering from chemotherapy or organ transplantation. "Our results suggest that megakaryocytes might be used clinically to facilitate adult stem cell regeneration and to expand cultured cells for adult stem cell transplants," says Meng Zhao, Ph.D., a postdoctoral fellow at Stowers and lead author on the study. Stowers researchers discovered that megakaryocytes directly regulate the function of murine hematopoietic stem cells -- adult stem cells that form blood and immune cells and that constantly renew the body's blood supply. These cells can also develop … Continue reading →

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Scientists Grow, Implant Human Intestinal Tissue in Mice

Posted: Published on October 21st, 2014

SUNDAY, Oct. 19, 2014 (HealthDay News) -- New stem cell-based research could improve understanding of intestinal diseases and eventually lead to new treatments, a new study suggests. Scientists used stem cells to grow "organoids" of functioning human intestinal tissue in a lab dish. They then transplanted the organoids into mice, creating a new model for studying intestinal disorders, according to the researchers. "This provides a new way to study the many diseases and conditions that can cause intestinal failure, from genetic disorders appearing at birth to conditions that strike later in life, such as cancer and Crohn's disease," lead investigator Dr. Michael Helmrath, surgical director of the Intestinal Rehabilitation Program at the Cincinnati Children's Hospital Medical Center, said in a center news release. "These studies also advance the longer-term goal of growing tissues that can replace damaged human intestine," he added. Further research could eventually lead to the ability to create personalized human intestinal tissue to treat gastrointestinal diseases, according to the researchers. "These studies support the concept that patient-specific cells can be used to grow intestine," Helmrath explained. The research was published online Oct. 19 in the journal Nature Medicine. The intestinal organoids were created using so-called pluripotent stem … Continue reading →

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